Search results for "ERAS"
showing 10 items of 4431 documents
Divergent temperature-specific metabolic and feeding rates of native and invasive crayfish
2022
Temperature is one of the most important factors governing the activity of ectothermic species, and it plays an important but less studied role in the manifestation of invasive species impacts. In this study, we investigated temperature-specific feeding and metabolic rates of invasive and native crayfish, and evaluated how temperature regulates their ecological impacts at present and in future according to different climatic scenarios by bioenergetics modelling. We conducted a series of maximum food consumption experiments and measured the metabolic rates of cold-adapted native noble crayfish (Astacus astacus) and invasive signal crayfish (Pacifastacus leniusculus) originally from a warmer …
Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
2012
Expansion of CAG repeats is a common feature of various neurodegenerative disorders, including Huntington's disease. Here we show that expanded CAG repeats bind to a translation regulatory protein complex containing MID1, protein phosphatase 2A and 40S ribosomal S6 kinase. Binding of the MID1-protein phosphatase 2A protein complex increases with CAG repeat size and stimulates translation of the CAG repeat expansion containing messenger RNA in a MID1-, protein phosphatase 2A- and mammalian target of rapamycin-dependent manner. Our data indicate that pathological CAG repeat expansions upregulate protein translation leading to an overproduction of aberrant protein and suggest that the MID1-com…
Savvaļas pārnadžu populācijas novērtēšana, izmantojot vizuālo atpazīšanu meža kameru datos, un salīdzināšana ar apmācītas mašīnmācīšanās modeļa rezul…
2022
Eiropā pēdējās desmitgadēs strauji palielinās pārnadžu populācijas, kas ik gadu rada simtiem miljonus eiro zaudējumos, tāpēc ir nepieciešamas metodes, lai efektīvi novērtētu pārnadžu populācijas. Meža kameras var būt labs risinājums, lai aizstātu uz vizuālajiem novērojumiem balstītas uzskaites bet tās ievāc lielus datu apjomus, kuru analīze aizņem ilgu laiku. To var risināt dziļās mašīnmācīšanās modeļi. No 2021. gada 1.janvāra teritorijā pie Rāmuļiem visu gadu tika izliktas 22 meža kameras, ar kurām tika noteikts pārnadžu relatīvais daudzuma indekss. Staltbrieži sastādīja 83,2%, stirnas 8,2%, aļņi 3,8% un meža cūkas 4,6%. Tika uztrenēts YOLOv5 mašīnmācīšanās modelis, kurš spēja atpazīt pārn…
El uso de microesferas de vidrio marcadas con Itrio-90 en el tratamiento del hepatocarcinoma
2021
OBJETIVO: Establecer el valor pronóstico de las variables incluidas en el estudio (clínicas, dosimétricas, analíticas y demográficas) en la progresión de enfermedad y la supervivencia global de aquellos pacientes afectos de hepatocarcinoma en estadio intermedio y avanzado del BCLC y tratados con radioembolización con microesferas cargadas con Y90, así como los efectos secundarios derivados del tratamiento. MATERIAL Y MÉTODO: Estudio retrospectivo, analítico y observacional realizado en el Hospital Universitario y Politécnico la Fe (Valencia) que incluye a 53 pacientes tratados con radioembolización desde marzo de 2009 hasta diciembre de 2016. Todos ellos fueron clasificados según el algorit…
Impacto de la crisis en las políticas y prácticas de salud en Portugal: una mirada a la salud materno-infantil y reproductiva considerando la diversi…
2016
La crisis que se inició en 2008 y la llegada de Troika en 2011 en Portugal, trajo aparejados cambios significativos en el acceso a los servicios de salud, implicando tanto el deterioro de la salud como el aumento de las desigualdades en salud, particularmente en las poblaciones vulnerables, entre ellas las mujeres inmigrantes y sus familias. El presente trabajo de cariz cualitativo tiene como fuente empírica el análisis de 185 entrevistas (profesionales de salud, líderes de asociaciones, y mujeres inmigrantes y autóctonas) y observación participante. En él ilustramos con casos concretos las barreras de acceso a los servicios de salud, especialmente en la salud materno-infantil y salud repro…
Mobiililaitteiden hyödyntäminen vieraiden kielten opetuksessa
2012
Tässä kandidaatintutkielmassa tarkastellaan mobiililaitteiden hyödyntämismahdollisuuksia vieraiden kielten opetuksessa. Tutkielmassa selvitetään ensin mitä on mobiilioppiminen, ja mikä on sen suhde vieraiden kielten opetuksen pedagogiaan. Tämän jälkeen tarkastellaan tutkimuksia siitä, kuinka mobiililaitteita on hyödynnetty vieraiden kielten opetuksen tukena. Lopuksi esitellään tutkimusten tarkastelun pohjalta tehdyt johtopäätökset.
Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening.
2015
In drug discovery the reliable prediction of binding free energies is of crucial importance. Methods that combine molecular mechanics force fields with continuum solvent models have become popular because of their high accuracy and relatively good computational efficiency. In this research we studied the performance of molecular mechanics generalized Born surface area (MM-GBSA), molecular mechanics Poisson-Boltzmann surface area (MM-PBSA), and solvated interaction energy (SIE) both in their virtual screening efficiency and their ability to predict experimentally determined binding affinities for five different protein targets. The protein-ligand complexes were derived with two different app…
The role and presence of conflicts in romantic Erasmus relationships
2017
The present study assesses the presence and importance of conflicts in intercultural relationships that were created during an Erasmus exchange period abroad. The theoretical background is based upon the concepts of third culture building (TCB) and conflict management styles, both of which were used to explain the various stages of the relationship development. So far the scholarly literature on the subject of Erasmus students is rather scarce and only a few studies focus on intercultural couples’ lived experiences concerning conflicts. This study is driven by the need for more developed and valid information of Erasmus couples that in fact form a rather large number of the Erasmus students…
Wienin yliopiston suomen kielen opiskelijoiden oppimismotivaatio
2005
Media landscapes in school and in free time – two paralel realities?
2008
This article is based on an extensive research project (Towards Future Literacy Pedagogies, ToLP1 ) that deals with the literacy practices of Finnish and immigrant pupils, mother tongue (MT) and foreign language (FL) teachers. The overall aim of the project is to explore and interpret literacy practices both in school and out-of-school contexts by employing large-scale quantitative research approaches as well as qualitative classroom observations and teacher and pupil interviews. In this article, we will report findings of the comprehensive survey, our specific focus being on the materials and media the teachers and pupils use in school and in their free time. We are interested in exploring…