Search results for "ESHAP"
showing 10 items of 20 documents
Brentuximab Vedotin Plus ESHAP (BRESHAP) Versus ESHAP As Salvage Strategy for Patients with Primary Refractory or Relapsed Classical Hodgkin's Lympho…
2021
Abstract Introduction. Patients with relapsed/refractory classical Hodgkin's lymphoma (RRHL) still represent a therapeutic challenge. Consolidation with autologous stem cell transplantation (auto-HCT) is the standard of care in this setting. The achievement of a metabolic complete remission (mCR) with salvage chemotherapy (CT) improves long-term outcome after auto-HCT. The introduction of new drugs has significantly changed the landscape of RRHL. Our cooperative group (GELTAMO) has already demonstrated that brentuximab vedotin (BV) + ESHAP (BRESHAP, García-Sanz R et al, Ann Oncol 2019) is able to achieve a mCR rate of 70% before auto-HCT in patients with RRHL. Nevertheless, the superiority …
Il piccolo nel grande, il grande nel piccolo. Gli adeguamenti liturgici di Culotta e Leone The small in the big, the big in the small. Culotta and Le…
2015
Una esplorazione degli adeguamenti liturgici di Pasquale Culotta e Giuseppe Leone conduce a comprendere in che modo la loro riflessione sulle architetture per il culto cristiano cattolico sia parte integrante della sperimentazione progettuale incentrata sul rapporto architettura-città. Nel saggio si specifica in cosa consista il lavoro di adeguamento rispetto alle indicazioni formulate nel Concilio Ecumenico Vaticano II (1963). Ci si sofferma sulle peculiarità della liturgia rinnovata: il valore "processionale" dello spazio ecclesiale e la relazione immanente-trascendente, a scala architettonica e urbana. In seguito si approfondiscono, "caso per caso", la riconfigurazione dell'ambone del Du…
New Technique for Aortic Valve Functional Annulus Reshaping Using a Handmade Prosthetic Ring
2011
Background Despite a wide development in aortic leaflets repair techniques, aortic valve annuloplastic procedures are still poorly investigated. We present our aortic valve annuloplastic system consisting of a handmade prosthetic ring with 2 components for reshaping the aortic annulus and sinotubular junction (STJ) and illustrates our surgical approach and clinical results. Methods Since February 2003, 45 patients with aortic valve regurgitation underwent aortic annuloplasty using the new ring. Mean patient age was 58 ± 16 years (range, 46 to 76 years). The ring has 2 components: a circular ring used to undersize the circumference of the aortoventricular junction and 3-crown-like shape ring…
RESHAPING AS NOVEL CIRCULAR ECONOMY STRATEGY FOR SHEET METAL BASED END-OF-LIFE COMPONENTS
2022
Making materials consumes about 21% of the global energy demand a specifically metals production, it accounts for about 8% of total global energy consumption. In fact, in the past few decades, the use of lightweight alloys has become increasingly widespread in many major industrial sectors thanks to the weight reduction associated with their applications. Most lightweight materials like aluminum alloys are characterized by high-energy demands primary production cycles that are responsible for a relevant share of the global CO2 emissions. Circular economy strategies such us longer life, more intense use, repair, product upgrades, modularity, remanufacturing, component re-use and open/closed …
Reshaping End-of-Life components by sheet hydroforming: An experimental and numerical analysis
2022
In this study, a numerical/experimental analysis is proposed to investigate the possibility of reshaping sheet metal-based End-of-Life (EoL) components using sheet Hydroforming (SHF). Returned EoL components are challenging to be reformed, they are usually characterised by high heterogeneity as there are localised thinning areas (caused by the original forming processes), and the overall formability is reduced with respect to the original flat sheet material. The reshaping route was replicated: a deep drawing process was adopted to impart a square feature; subsequently, SHF was performed. The capability of remove the deep drawn feature was analysed with varying Blank-holder force, oil press…
Influència de la curvatura del conducte radicular i del moviment en la fatiga cíclica dels instruments de sistemes de llima única
2015
L’objectiu de l’estudi ha sigut avaluar la resistència a la fatiga cíclica de quatres sistemes de llima única en conductes corbats, estudiar la influència del moviment i de l’àrea de la secció transversal. Metodologia. S’utilitzaren un total de 240 llimes noves de 4 sistemes de llima única amb un diàmetre a la punta de 0,25mm: 60 llimes WaveOne Primary (Densply-Maillefer), 60 llimes Reciproc R25 (VDW), 60 llimes OneShape (Micro-Mega) i 60 llimes F360 #25 (Komet Brasseler); que foren dividides de manera aleatòria en 24 grups (ni=10). Prèviament a l’estudi tots els instruments van ser inspeccionats amb un lupa estereomicroscòpica de 16 augments, per a anàlisi morfològic i per descartar qualse…
Symmetry-adapted tensorial formalism to model rovibrational and rovibronic spectra of molecules pertaining to various point groups
2004
International audience; We present a short review on the tensorial formalism developed by the Dijon group to solve molecular spectroscopy problems. This approach, originally devoted to the rovibrational spectroscopy of highly symmetrical species (spherical tops) has been recently extended in several directions: quasi-spherical tops, some symmetric and asymmetric tops, and rovibronic spectroscopy of spherical tops in a degenerate electronic state. Despite its apparent complexity (heavy notations, quite complex mathematical tools), these group theoretical tensorial methods have a great advantage of flexibility: a systematic expansion of effective terms for any rovib- rational/rovibronic probl…
Speed-dependent line profile: A test of a unified model from the Doppler to the collisional regime for molecule-molecule collisions
2000
International audience; A speed-dependent line profile combining soft and hard fully correlated Dicke-narrowing collisions was recently successfully tested on Ar-broadened H-2 spectra in a wide density and temperature range. A further test for mixtures of H-2 in nitrogen molecules (instead of Ar atoms) is presented. This test is also based on high resolution Raman investigation of the isotropic Q(1) line of H-2 from low to high density at various temperatures. The same consistency of the speed-dependent line profile as for H-2-Ar is obtained for H-2-N-2 through a remarkable agreement with all the data by using a unique set of four parameters (the collisional width and shift, the kinetic fre…
Collisional effects on spectral line shape from the Doppler to the collisional regime: A rigorous test of a unified model
2000
International audience; The paper presents high resolution Raman investigations of the Q(1) line of H-2 in Ar mixture from low density (Doppler regime) to high density (collisional regime) analyzed with a unique line shape profile. Measurements are performed by stimulated Raman gain spectroscopy between 300 and 1000 K in a wide density range (from 0.2 to 11 amagat). All the observed spectral features are accurately described by a unified model recently proposed by two of the authors. This model accounts for a velocity-memory process, not restricted to the usual hard and soft limits. It also includes correlation between velocity- and phase-changing collisions. An exhaustive analysis of vario…
Estar al otro lado de la mesa. Profesionales de los servicios públicos de empleo ante los dilemas de la activación laboral
2019
Under the paradigm of activation, the Public Employment Services has been reshaped by two levels of contractualization. On one hand, the collaboration of the administration with a network of agents on the programme scheme that make up the active policies of employment. On the other hand, the unemployed person?s access to a compartmentalized offer of services and individually taking responsibility for finding work. This double contractualization reveals redefinition of lowering public responsibility faced with the problem of unemployment that this activation supposes. This paper analyses how this redesign has an impact on how professionals serve the unemployed population. This lays bare, in …