Search results for "ESL"
showing 10 items of 250 documents
Reslizumab as add-on therapy in patients with refractory asthma
2020
### Key messages #### What is the key question? #### What is the bottom line? #### Why read on? Asthma is a common disease, affecting an estimated 334 million people worldwide, with considerable impact on quality of life and high associated costs.1–3 Asthma severity is assessed retrospectively from the level of treatment required to control symptoms and exacerbations. Approximately 5%–10% of patients with asthma are believed to suffer from severe disease.4 Patients with severe asthma typically require ongoing maintenance therapy with high-dose inhaled corticosteroid (ICS)/long-acting beta-agonist (LABA).2 Furthermore, systemic corticosteroids (SCS) are often required for potentially life-th…
Naturally Occurring Telomerase-Specific CD4 T-Cell Immunity in Melanoma.
2020
CD4 T cells play a key role in anticancer immunity. In this study, we investigate the clinical relevance of circulating CD4 T helper type 1 (Th1) response against telomerase (anti-TERT Th1 response) in patients with melanoma. The spontaneous anti-TERT Th1 response was detected in 54.5% (85/156) of patients with melanoma before treatment. The prevalence of this systemic response was inversely related to Breslow thickness >1 mm and American Joint Committee on Cancer stage ≥II (P = 0.001 and 0.032, respectively). In contrast to patients treated with targeted therapies, the anti-TERT Th1 immunity was associated with an objective response after immune checkpoint inhibitors treatment. Hence, 86% …
Effects of Reslizumab on Asthma Outcomes in a Subgroup of Eosinophilic Asthma Patients with Self-Reported Chronic Rhinosinusitis with Nasal Polyps.
2019
Background An estimated 7% of patients with asthma have chronic rhinosinusitis with nasal polyps (CRSwNP), and more than 80% have at least some radiographic evidence of sinonasal inflammation. Aspirin sensitivity is strongly associated with elevated blood eosinophil levels and increased asthma severity. Intravenous (IV) reslizumab has been shown to improve asthma control in patients with nasal polyps. Objective These post hoc analyses of pooled data from 2 BREATH phase 3 clinical trials, studies 1 and 2 (NCT01287039 and NCT01285323), examined asthma-related outcomes in patients with comorbid, self-reported CRSwNP with and without aspirin sensitivity. Methods Patients aged 12-75 years with e…
Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
2012
BACKGROUND: Some patients with severe asthma have recurrent asthma exacerbations associated with eosinophilic airway inflammation. Early studies suggest that inhibition of eosinophilic airway inflammation with mepolizumab-a monoclonal antibody against interleukin 5-is associated with a reduced risk of exacerbations. We aimed to establish efficacy, safety, and patient characteristics associated with the response to mepolizumab. METHODS: We undertook a multicentre, double-blind, placebo-controlled trial at 81 centres in 13 countries between Nov 9, 2009, and Dec 5, 2011. Eligible patients were aged 12-74 years, had a history of recurrent severe asthma exacerbations, and had signs of eosinophil…
Clinicopathological analysis of 1571 cutaneous malignant melanomas in Valencia, Spain: factors related to tumour thickness.
2006
Epidemiological studies on cutaneous melanoma in Mediterranean countries are scarce. Our aim was to perform a descriptive analysis of melanoma cases diagnosed in Valencia, Spain, and to evaluate the relationship between Breslow thickness and some clinical features. A total of 1571 patients with histologically confirmed cutaneous malignant melanoma diagnosed at the two main referral melanoma centres were evaluated retrospectively. For each patient the following clinical and pathological characteristics were selected: age, gender, anatomic site, histogenetic type, Breslow thickness, presence of ulceration, the stage, and symptoms such as bleeding, changes in size and colour, altered sensation…
Clinical performance of the Nevisense system in cutaneous melanoma detection: an international, multicentre, prospective and blinded clinical trial o…
2014
Summary Background Even though progress has been made, the detection of melanoma still poses a challenge. In light of this situation, the Nevisense electrical impedance spectroscopy (EIS) system (SciBase AB, Stockholm, Sweden) was designed and shown to have the potential to be used as an adjunct diagnostic tool for melanoma detection. Objectives To assess the effectiveness and safety of the Nevisense system in the distinction of benign lesions of the skin from melanoma with electrical impedance spectroscopy. Methods This multicentre, prospective, and blinded clinical study was conducted at five American and 17 European investigational sites. All eligible skin lesions in the study were exami…
Let me in. Visioni architettoniche per habitat multispecie
2020
I disegni di Alessandro Melis sono lo spunto per una descrizione interpretativa, orientata a mettere in luce l’espressione di un nuovo rapporto fra uomo e non umani come tema dell’architettura contemporanea. L’immaginario che agisce nei disegni esaminati predispone, come sempre in architettura, lo scenario di fondo cui prepararsi per i reali interventi disciplinari. La ripresa degli organi zoomorfi o delle macchine tecno-sensoriali di Coop Himmel(b)lau, a loro volta eco delle prime introduzioni di Archigram, del bowellism di Frederick Kiesler, dei sistemi viventi di Hans Hollein, prolunga nel contemporaneo l’eco di una ricerca di apertura del campo disciplinare. La novità, nella frontiera v…
‘How this holiday makes a difference’: The language of environment and the environment of nature in a cross-cultural study of ecotourism
2010
Partendo dal presupposto che le differenze culturali spesso costituiscono una fonte potenziale di problematiche traduttive, questo contributo mira a evidenziare le differenze che emergono sul piano linguistico, a livello lessicale, ma soprattutto fraseologico, in seguito a variegati orientamenti culturali che agiscono come filtri. Il linguaggio specialistico analizzato riguarda una nicchia particolare del mercato del turismo, ossia l’ecoturismo, che sta conquistando un terreno sempre più vasto in seguito ad una maggiore attenzione rivolta nei confronti di tematiche attuali, come quelle di impatto ambientale. Abbracciando una prospettiva interculturale, il lavoro indaga il diverso approccio …
Wesley Clair Mitchell and the “Illiberal Reformers”: A Documentary Note
2021
In this note we inquire whether Mitchell as a reformer ever expressed concern over the biological quality of individuals and whether he did somehow share the Progressive Era faith in eugenics as an instrument for improving American society’s health, welfare, and morals. This is an aspect of Mitchell’s thought that has received scant attention in the literature and that projects him into the current debate on progressivism.
Vārda brīvība un atbildība par neslavas celšanu elektroniskā vidē
2021
Saskaņā ar Latvijas Republikas Krimināllikumu, neslavas celšana tiek uzskatīta par noziedzīgu nodarījumu. Noziedzīgais nodarījums par neslavas celšanu tiek regulēts Krimināllikuma 157.pantā. Ņemot vērā pieminētā panta saturu, praksē var saskatīt problēmas, kuras saistītas ar cilvēktiesību sadursmi. Sabiedrībā līdz šim brīdim nav skaidra izpratne par aizskarošas informācijas publiskošanu un ietekmi uz vārda brīvību, kas ir demokrātiskas valsts iekārtas stūrakmens. Latvijas juridiskajā literatūrā trūkst plaši skaidrojumi par neslavas celšanas problēmjautājumiem, it īpaši elektroniskā vidē. Darba galvenā būtība ir izpētīt neslavas celšanas institūta būtību, aplūkojot teoriju, tiesu praksi, kā …