Search results for "EURA"
showing 10 items of 3336 documents
Adversarial reverse mapping of equilibrated condensed-phase molecular structures
2020
A tight and consistent link between resolutions is crucial to further expand the impact of multiscale modeling for complex materials. We herein tackle the generation of condensed molecular structures as a refinement -- backmapping -- of a coarse-grained structure. Traditional schemes start from a rough coarse-to-fine mapping and perform further energy minimization and molecular dynamics simulations to equilibrate the system. In this study we introduce DeepBackmap: A deep neural network based approach to directly predict equilibrated molecular structures for condensed-phase systems. We use generative adversarial networks to learn the Boltzmann distribution from training data and realize reve…
Non-exponential relaxation in disordered materials: Phenomenological correlations and spectrally selective experiments
1998
Abstract In most glass-forming materials external perturbations are relaxed in a non-exponential fashion. It is shown that the degree of non-exponentiality is phenomenologically correlated with the departure from simple thermally activated behavior as measured by the fragility index m. In model glass formers such as the Ge-As-Se ternary alloy, and to some degree for amorphous materials in general, the correlations with these properties are observed also for other characteristic features. These include the specific heat step and the aging kinetics in the glass transformation range. While phenomenological correlations have proven very useful for rationalizing the properties of many glass form…
Long-Term Potentiation in the Recurrent Inhibitory Circuit of the Dentate Gyrus
1988
The question of whether long-term potentiation occurs in the inhibitory circuits of the hippocampus remains controversial. Buszaki and Eidelberg (1982), recording extracellularly from putative interneurones (basket cells) in the dentate gyrus and area CAl of the anaesthetized rat, found a prolonged increase in probability of cell firing to afferent stimulation after high-frequency stimulation of Schaffer-commissural fibres, and concluded that LTP occurs at excitatory feedforward synapses onto interneurones. Similarly, Kairis et al (1987) have presented field potential evidence for LTP in feedforward synapses onto inhibitory neurones in the dentate gyrus of the anaesthetized rat. In the hipp…
Dual effects of increased glycogen synthase kinase-3β activity on adult neurogenesis
2013
Adult neurogenesis, the generation of new neurons during the adulthood, is a process controlled by several kinases and phosphatases among which GSK3β exerts important functions. This protein is particularly abundant in the central nervous system, and its activity deregulation is believed to play a key role in chronic disorders such as Alzheimer's disease. Previously, we reported that in vivo overexpression of GSK3β (Tet/GSK3β mice) causes alterations in adult neurogenesis, leading to a depletion of the neurogenic niches. Here, we have further characterized those alterations, finding a delay in the switching-off of doublecortin marker as well as changes in the survival and death rates of imm…
Artificial neural network for quantitative determination of total protein in yogurt by infrared spectrometry
2009
Abstract A method has been introduced for quantitative determination of protein content in yogurt samples based on the characteristic absorbance of protein in 1800–1500 cm− 1 spectral region by mid-FTIR spectroscopy and chemometrics. Successive Projection Algorithm (SPA) wavelength selection procedure, coupled with feed forward Back-Propagation Artificial Neural Network (BP-ANN) model was the benefited chemometric technique. Relative Error of Prediction (REP) in BP-ANN and SPA-BP-ANN methods for training set was 7.25 and 3.70 respectively. Considering the complexity of the sample, the ANN model was found to be reliable, while the proposed method is rapid and simple, without any sample prepa…
Medikamentöse Therapie progredienter kindlicher Hörstörungen
1991
In 1987 and 1988 Nickisch et al. discussed the effect of infusions of prednisolone, pentoxifylline and, partially, piracetam in Ringer lactate solvent on progressive sensorineural hearing loss in childhood and adolescence. Time of observations was 4 years. Unfortunately long-term investigations could not confirm the initially good therapeutic results of 1987/88. In 35% were found permanently and in 12.5% temporarily better auditory thresholds after infusion. The loss of progressive sensorineural hearing in childhood usually takes a fateful course that can hardly be influenced. As is the case with adults, good therapeutic results can most probably be achieved by infusions starting close to t…
Ghost cell odontogenic carcinoma: a rare case report and review of literature
2014
Objectives: Ghost cell odontogenic carcinoma is a rare condition characterized by ameloblastic-like islands of epithelial cells with aberrant keratinitation in the form of Ghost cell with varying amounts of dysplastic dentina. Material and Methods: We report a case of a 70 year-old woman with a rapid onset of painful swelling right maxillary tumor. Magnetic resonance showed a huge tumor dependent on the right half of the right hard palate with invasion of the pterygoid process and focally to the second branch of the trigeminal. Radiological stage was T4N0. The patient underwent a right subtotal maxillectomy with clear margins. Adjuvant radiotherapy was given. The patient was free of residua…
Russian concept of the Eurasian Aerospace Defense System. Analysis of the problem
2018
The author of the article describes the most important theses of A. Podberezkin plan against the geopolitical Russia background which form a paradigm of a common security in Russian terms on a strategic area of Eurasia. It is of a particular significance in view of the growing threats to modern world. Especially of hazardous nature is current problem of North Korea in connection with nuclear testing carried out by unpredictable regime of Kim Jong-un which creates the risk that sudden conflict can drag the whole Peninsula into a war. This, in turn, would lead to the US intervention there. Effects of the possible conflict involving superpower are hard to predict. Another current problem is Mo…
Chlorophyll Concentration Retrieval by Training Convolutional Neural Network for Stochastic Model of Leaf Optical Properties (SLOP) Inversion
2020
Miniaturized hyperspectral imaging techniques have developed rapidly in recent years and have become widely available for different applications. Combining calibrated hyperspectral imagery with inverse physically based reflectance models is an interesting approach for estimating chlorophyll concentrations that are good indicators of vegetation health. The objective of this study was to develop a novel approach for retrieving chlorophyll a and b values from remotely sensed data by inverting the stochastic model of leaf optical properties using a one-dimensional convolutional neural network. The inversion results and retrieved values are validated in two ways: A classical machine learning val…
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells
2009
Epigenetic mechanisms that maintain neurogenesis throughout adult life remain poorly understood(1). Trithorax group (trxG) and Polycomb group (PcG) gene products are part of an evolutionarily conserved chromatin remodelling system that activate or silence gene expression, respectively(2). Although PcG member Bmi1 has been shown to be required for postnatal neural stem cell self-renewal(3,4), the role of trxG genes remains unknown. Here we show that the trxG member Mll1 (mixed-lineage leukaemia 1) is required for neurogenesis in the mouse postnatal brain. Mll1-deficient subventricular zone neural stem cells survive, proliferate and efficiently differentiate into glial lineages; however, neur…