Search results for "EVAS"

Lázaro Carreter-Vidal Beneyto: Del libro y su futuro

1983

Lázaro Carreter-Vidal Beneyto: Del libro y su futuro

1983

Peñón de la Zorra y Puntal de los Carniceros (Villena, Alicante): Revisión de dos conjuntos de yacimientos campaniformes en el corredor del Vinalopó

2002

En el presente artículo se revisa la información existente sobre dos yacimientos campaniformes del Alto Vinalopó –Peñón de la Zorra y Puntal de los Carniceros–. Su importancia dentro de la investigación en tierras levantinas los ha convertido en una referencia casi obligatoria desde su publicación por parte de J. M. Soler García. In this article is cheked information about two bell beaker sites from Vinalopo Valley –Peñón de la Zorra and Puntal de los Carniceros–. The importance of this archaeological sites of investigation concerning Levante areas have got that these places would be an obligatory reference since the publication by J.M. Soler Garcia.

Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance.

2023

Patients affected by colorectal cancer (CRC) with DNA mismatch repair deficiency (MMRd), often respond to immune checkpoint blockade therapies, while those with mismatch repair-proficient (MMRp) tumors generally do not. Interestingly, a subset of MMRp CRCs contains variable fractions of MMRd cells, but it is unknown how their presence impacts immune surveillance. We asked whether modulation of the MMRd fraction in MMR heterogeneous tumors acts as an endogenous cancer vaccine by promoting immune surveillance. To test this hypothesis, we use isogenic MMRp (Mlh1+/+) and MMRd (Mlh1-/-) mouse CRC cells. MMRp/MMRd cells mixed at different ratios are injected in immunocompetent mice and tumor reje…

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

2015

As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.

Epicardial delivery of collagen patches with adipose-derived stem cells in rat and minipig models of chronic myocardial infarction.

2013

Although transplantation of adipose-derived stem cells (ADSC) in chronic myocardial infarction (MI) models is associated with functional improvement, its therapeutic value is limited due to poor long-term cell engraftment and survival. Thus, the objective of this study was to examine whether transplantation of collagen patches seeded with ADSC could enhance cell engraftment and improve cardiac function in models of chronic MI. With that purpose, chronically infarcted Sprague-Dawley rats (n = 58) were divided into four groups and transplanted with media, collagen scaffold (CS), rat ADSC, or CS seeded with rat ADSC (CS-rADSC). Cell engraftment, histological changes, and cardiac function were …

Adipose Stromal Vascular Fraction Improves Cardiac Function in Chronic Myocardial Infarction Through Differentiation and Paracrine Activity

2012

Fresh adipose-derived cells have been shown to be effective in the treatment of acute myocardial infarction (MI), but their role in the chronic setting is unknown. We sought to determine the long-term effect of the adipose derived-stromal vascular fraction (SVF) cell transplantation in a rat model of chronic MI. MI was induced in 82 rats by permanent coronary artery ligation and 5 weeks later rats were allocated to receive an intramyocardial injection of 107 GFP-expressing fresh SVF cells or culture media as control. Heart function and tissue metabolism were determined by echocardiography and 18F-FDG-microPET, respectively, and histological studies were performed for up to 3 months after t…

Management of Patients with Asymptomatic and Symptomatic Carotid Artery Disease: Update on Anti-Thrombotic Therapy

2019

AbstractThe most common causes of ischaemic stroke are represented by carotid artery atherosclerotic disease (CAAD) and atrial fibrillation. While oral anticoagulants substantially reduce the incidence of thromboembolic stroke (< 1%/year), the rate of ischaemic stroke and other cardiovascular disease events in patients with CAAD remains high, ranging from 8.4 to 18.1 events per 100 patient-years. Similar to any other atherosclerotic disease, anti-thrombotic therapies are proposed for CAAD to reduce stroke and other cardiovascular events. The 2017 European Society of Cardiology (ESC)/European Society for Vascular Surgery (ESVS) guidelines recommend for patients with asymptomatic CAAD ≥60%…

Kinking, coiling, and tortuosity of extracranial internal carotid artery: is it the effect of a metaplasia?

2006

INTRODUCTION: Morphological anomalies of the extracranial internal carotid artery (ICA) cause symptomatic cerebrovascular insufficiency in 4-16% of the cases. The aim of the present study is to evaluate macroscopic and microscopic features of a group of extracranial ICA anomalies, specifically kinking, coiling, and tortuosity, eventually affecting the surgical approach. MATERIALS AND METHODS: From January 2003 to December 2005, 10 out of 169 (6%) revascularized patients (pts) were operated upon because of an ICA anomaly. They were all but two symptomatics. Seven pts were treated by ICA transection and end-to-side reimplantation of the ICA at the level of the carotid bulb; three pts were tre…

Il Cashback di Stato: evidenze empiriche e inquadramento fiscale

2020

I commi da 288 e 290 della Legge di Bilancio per il 2020 (Legge n. 160 del 27 Dicembre 2019) hanno introdotto anche in Italia le “Misure premiali per utilizzo di strumenti di pagamento elettronici”. Si tratta del meccanismo noto come cashback con il quale il governo italiano ha fatto un passo in avanti verso il traguardo di quella cashless society che, nelle intenzioni dei promotori, dovrebbe portare alla scomparsa del contante con effetti benefici sul contrasto all’evasione e ad altre forme di illeciti di natura economica. Le disposizioni normative, anche alla luce delle modifiche apportate dall’articolo 73 del D.L. n. 104 del 14 agosto 2020, prevedono un rimborso in denaro per le persone …