Search results for "EVASION"
showing 10 items of 81 documents
Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
2015
As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.
Il Cashback di Stato: evidenze empiriche e inquadramento fiscale
2020
I commi da 288 e 290 della Legge di Bilancio per il 2020 (Legge n. 160 del 27 Dicembre 2019) hanno introdotto anche in Italia le “Misure premiali per utilizzo di strumenti di pagamento elettronici”. Si tratta del meccanismo noto come cashback con il quale il governo italiano ha fatto un passo in avanti verso il traguardo di quella cashless society che, nelle intenzioni dei promotori, dovrebbe portare alla scomparsa del contante con effetti benefici sul contrasto all’evasione e ad altre forme di illeciti di natura economica. Le disposizioni normative, anche alla luce delle modifiche apportate dall’articolo 73 del D.L. n. 104 del 14 agosto 2020, prevedono un rimborso in denaro per le persone …
Immune evasion proteins of murine cytomegalovirus preferentially affect cell surface display of recently generated peptide presentation complexes.
2009
CD8 T cells recognize infected cells by interaction of their T-cell receptor (TCR) with a cell surface presentation complex composed of a cognate antigenic peptide bound to a presenting allelic form of a major histocompatibility complex class I (MHC-I) glycoprotein (77, 85, 97, 98). The number of such “peptide receptors” per cell has been estimated to be on the order of 105 to 106 for each MHC-I allomorph (for a review, see reference 82). Viral antigenic peptides are generated within infected cells by proteolytic processing of viral proteins, usually in the proteasome, and associate with nascent MHC-I proteins in the endoplasmic reticulum (ER) before the peptide-MHC (pMHC) complexes travel …
Object and subject of evasion of taxes and other compulsory payments
2014
The paper is devoted to such topical issue of Criminal Law as Object and Subject of Evasion of Taxes and Other Compulsory Payments. There are analyzed researched crime determination problems, which are connected with subject and object of tax and other compulsory payments evasion. In the course of the research, the author has made the conclusions that the object of the evasion of taxes and other compulsory payments group is the national economic interests. The direct object is the national economic interests in the sphere of state revenues or the national fiscal interests. While analyzing the law and regulations it is concluded that the subject of the evasion of taxes and other compulsory p…
Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion.
2013
Control of human cytomegalovirus (HCMV) depends on CD8+ T cell responses that are shaped by an individual's repertoire of MHC molecules. MHC class I presentation is modulated by a set of HCMV-encoded proteins. Here we show that HCMV immunoevasins differentially impair T cell recognition of epitopes from the same viral antigen, immediate-early 1 (IE-1), that are presented by different MHC class I allotypes. In the presence of immunoevasins, HLA-A- and HLA-B-restricted T cell clones were ineffective, but HLA-C*0702-restricted T cell clones recognized and killed infected cells. Resistance of HLA-C*0702 to viral immunoevasins US2 and US11 was mediated by the alpha3 domain and C-terminal region …
Chemotherapy Sensitizes Colon Cancer Initiating Cells to Vγ9Vδ2 T Cell-Mediated Cytotoxicity
2013
Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is responsible for tumor maintenance and resistance to anti-cancer therapies, possibly allowing for tumor recapitulation once treatment stops. Combinations of immune-based therapies with chemotherapy and other anti-tumor agents may be of significant clinical benefit in the treatment of colon cancer. However, cellular immune-based therapies have not been experimented yet in the population of colon CICs. Here, we demonstrate that treatment with low concentrations of commonly used chemotherapeutic agents, 5- fluorouracyl and doxorubicin, sensitize colon CICs to Vc9Vd2 T cell cytotoxicity. Vc9Vd2 T cell cytotox…
Fiscal competition. Definizioni e modalità concrete
2016
Questo lavoro si propone di analizzare le caratteristiche della competizione fiscale, nel framework della globalizzazione reale e finanziaria, e le sue implicazioni nelle relazioni tra Stati e imprese multinazionali. Peraltro, lo stesso rappresenta la prima tappa di un più complesso studio che si propone di analizzare gli effetti positivi e negativi della tax competition e bank secrecy competition. Di fatti, il risultato della fiscal competition è dato da due differenti, ma relazionati, tipi di competizione: quella più propriamente tributaria e quella " bancaria ". Quanto alla prima, la nostra analisi mira a rivelare il fenomeno per il quale gli Stati sovrani cercano di attrarre sia gli inv…
Tax compliance and wealth inequality
2019
In this work, we theoretically approach optimal taxing in a public good provision context in a society where wealth is Pareto distributed. Our main result shows that high levels of wealth inequalit...
Modulation of immune responses of Rhynchophorus ferrugineus (Insecta: Coleoptera) induced by the entomopathogenic nematode Steinernema carpocapsae (N…
2014
Aim of this study was to investigate relationships between the red palm weevil (RPW) Rhynchophorus ferrugineus (Olivier) and the entomopathogenic nematode Steinernema carpocapsae (EPN); particularly, the work was focused on the immune response of the insect host in naive larvae and after infection with the EPN. Two main immunological processes have been addressed: the activity and modulation of host prophenoloxidase-phenoloxidase (proPO) system, involved in melanization of not-self and hemocytes recognition processes responsible for not-self encapsulation. Moreover, immune depressive and immune evasive strategies of the parasite have been investigated. Our results suggest that RPW possess a…
Contrasto all’evasione dei tributi locali : illegittimità di sospensione e revoca di licenze e concessioni?
2022
Il contesto storico nel quale si inserisce la fiscalità degli enti locali, con le rilevanti criticità relative all’alto tasso di evasione e, più in generale, al loro equilibrio finanziario, è particolarmente difficile e notevolmente aggravato dalla epocale pandemia che ci ha colpiti. In tale ambito una particolare attenzione deve essere prestata alle misure di prevenzione e contrasto dell’evasione dei tributi locali con specifico riferimento alle attività di accertamento e riscossione, tenendo conto dell’esigenza urgente ed indifferibile di un radicale intervento di ricostruzione dell’intero impianto dell’autonomia finanziaria dei Comuni che ne faccia risorgere la sua identità da quelle che…