Search results for "EXPRESSION"
showing 10 items of 5168 documents
pcaExplorer
2017
This package provides functionality for interactive visualization of RNA-seq datasets based on Principal Components Analysis. The methods provided allow for quick information extraction and effective data exploration. A Shiny application encapsulates the whole analysis.
Central Serotonin2C Receptor: From Physiology to Pathology
2006
Since the 1950s, when serotonin (5-HT) was discovered in the mammalian central nervous system (CNS), an enormous amount of experimental evidence has revealed the pivotal role of this biogenic amine in a number of cognitive and behavioural functions. Although 5-HT is synthesized by a small group of neurons within the raphe nuclei of the brain stem, almost all parts of the CNS receive serotonergic projections. Furthermore, the importance of 5-HT modulation and the fine-tuning of its action is underlined by the large number of 5-HT binding sites found in the CNS. Hitherto, up to 15 different 5-HT receptors subtypes have been identified. This review was undertaken to summarize the work that has…
Serum Response Factor-Mediated Gene Regulation in a Drosophila Visual Working Memory
2013
Summary Background Navigation through the environment requires a working memory for the chosen target and path integration facilitating an approach when the target becomes temporarily hidden. We have previously shown that this visual orientation memory resides in the ellipsoid body, which is part of the central complex in the Drosophila brain. Former analysis of foraging and ignorant mutants have revealed that a hierarchical PKG and RSKII kinase signaling cascade in a subset of the ellipsoid-body ring neurons is required for this type of working memory in flies. Results Here we show that mutants in the ellipsoid body open ( ebo ) gene, which encodes the actin-binding protein Exportin 6, e…
Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels
2019
Abstract Background Due to unmet need for bone augmentation, our aim was to promote osteogenic differentiation of human adipose stem cells (hASCs) encapsulated in gellan gum (GG) or collagen type I (COL) hydrogels with bioactive glass (experimental glass 2-06 of composition [wt-%]: Na2O 12.1, K2O 14.0, CaO 19.8, P2O5 2.5, B2O3 1.6, SiO2 50.0) extract based osteogenic medium (BaG OM) for bone construct development. GG hydrogels were crosslinked with spermidine (GG-SPD) or BaG extract (GG-BaG). Methods Mechanical properties of cell-free GG-SPD, GG-BaG, and COL hydrogels were tested in osteogenic medium (OM) or BaG OM at 0, 14, and 21 d. Hydrogel embedded hASCs were cultured in OM or BaG OM fo…
Multiobjective service restoration in distribution networks using an evolutionary approach and fuzzy sets
2000
Abstract In this article, the service restoration (SR) problem in electrical distribution networks is dealt with using an evolutionary strategy (ES) with a fuzzy definition of the conflicting objectives. The normal operation status allows the remote control of tie-switches, of capacitor banks and load connection. When a permanent fault occurs, the same remote control actions can be performed with the aim of restoring the service in the concerned areas. The status of these remotely controllable elements is the boolean optimisation variables for the SR problem. Besides this, here the SR problem is dealt with in a multiple objectives (MO) formulation. Indeed, the power losses’ term is consider…
Relativistic Positioning Systems in Flat Space-Time: The Location Problem
2013
The location problem in relativistic positioning is considered in flat space-time. When two formal solutions are possible for a user (receiver) of the system, its true location may be obtained from a standard set of emission data extended with an observational rule. The covariant expression giving the location of the user in inertial coordinates is decomposed with respect to an inertial observer.
Discrete-time static output-feedback semi-decentralized H<inf>&#x221E;</inf> controller design: An application to structural vibratio…
2012
In this work, we present a new and effective method to design discrete-time static output-feedback H ∞ controllers. This new method, based on a Linear Matrix Inequality (LMI) formulation, introduces a suitable transformation of the LMI variables that allows to obtain an explicit expression for the output-feedback gain matrix. Moreover, for problems involving a set of subsystems with information exchange constraints, a convenient structure on the LMI variables can be imposed in order to design semi-decentralized controllers, where the corresponding output-feedback gain matrix has a prescribed zero-nonzero structure. To illustrate the proposed methodology, discrete-time static velocity-feedba…
Working with (too) Few Samples
2018
This paper is concerned with gene set differential expression analysis. We compare the transcriptomic behaviour of each gene set between different experimental conditions.The gene set is previously defined. It has been used a gene set collection downloaded from Gene Ontology.A randomization test is proposed and compared with other previous procedures using a RNA-seq experiment of colorectal cancer (CRC).
GIBBERELLINS REGULATE CELL DIVISION AND PARTHENOCARPIC FRUIT SET IN CITRUS
Fruit set and growth is regulated by hormones interaction, gibberellins (GA) being a main part of the process in Citrus. Actually, it is well known the time-course of GA content in the citrus ovary during flowering and its correlation with fruit set in both seeded and seedless species. However, GA endogenous role is uncertain. Is GA in the ovary a direct regulator or an indirect part of the hormonal stimuli that reactivates and maintains cell division triggering fruit set? While in seeded varieties GA synthesis that occurs in fertilized ovules is the primary stimulus controlling early ovary development, is there any specific tissue-dependent regulation of parthenocarpy? While initiation of …
Evolution and functional differentiation of recently diverged phytochelatin synthase genes from Arundo donax L.
2019
Plant phytochelatin synthases undergo evolutionarily rapid functional differentiation after duplication, allowing fast and precise adjustment of metal detoxification capacity by modulation of both transcription and enzymatic activity.