Search results for "EXPRESSION"
showing 10 items of 5168 documents
Study of USH1 Splicing Variants through Minigenes and Transcript Analysis from Nasal Epithelial Cells
2012
Usher syndrome type I (USH1) is an autosomal recessive disorder characterized by congenital profound deafness, vestibular areflexia and prepubertal retinitis pigmentosa. The first purpose of this study was to determine the pathologic nature of eighteen USH1 putative splicing variants found in our series and their effect in the splicing process by minigene assays. These variants were selected according to bioinformatic analysis. The second aim was to analyze the USH1 transcripts, obtained from nasal epithelial cells samples of our patients, in order to corroborate the observed effect of mutations by minigenes in patient’s tissues. The last objective was to evaluate the nasal ciliary beat fre…
Loss of virulence in Ustilago maydis by Umchs6 gene disruption
2003
A gene encoding a sixth chitin synthase (Umchs6, sequence GenBank accession No. AF030554) from the plant pathogenic hemibasidiomycete Ustilago maydis (DC.) Cda. was isolated and characterized. The predicted protein is 1103 amino acids in length with a calculated molecular mass of 123.5 kDa. a2b2 null mutants were obtained by substitution of a central fragment of the Umchs6 gene with the hygromycin resistance cassette, and a1b1 null mutants were obtained by genetic recombination in plants of an a2b2Δch6 and a wild-type a1b1 strain. The mutation had no effect on the dimorphic transition in vitro or on mating, and growth rate of the mutants was only slightly reduced. On the other hand, they di…
Human Papilloma Virus-Dependent HMGA1 Expression Is a Relevant Step in Cervical Carcinogenesis
2008
HMGA1 is a member of a small family of architectural transcription factors involved in the coordinate assembly of multiprotein complexes referred to as enhanceosomes. In addition to their role in cell proliferation, differentiation, and development, high-mobility group proteins of the A type (HMGA) family members behave as transforming protoncogenes either in vitro or in animal models. Recent reports indicated that HMGA1 might counteract p53 pathway and provided an interesting hint on the mechanisms determining HMGA's transforming potential. HMGA1 expression is deregulated in a very large array of human tumors, including cervical cancer, but very limited information is available on the mole…
Performance Analysis of Alamouti Coded OFDM Systems over Rayleigh Fading Channels Correlated in Space and Time
2010
Paper presented at the 2010 IEEE 71st Vehicular Technology Conference, Taipei.(c) 2010 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works. Paper also available from the publisher: http://dx.doi.org/10.1109/VETECS.2010.5493855 This paper deals with the performance analysis of Alamouti coded orthogonal frequency division multiplexing (OFDM) systems over time-varying multipath Rayleigh fading channels. I…
Robust synchronization and fault detection of uncertain master-slave systems with mixed time-varying delays and nonlinear perturbations
2011
Publiahed version of an article in the journal: International Journal of Control, Automation and Systems. Also available from the publisher on SpringerLink: http://dx.doi.org/10.1007/s12555-011-0408-8 In this paper, the problem of robust synchronization and fault detection for a class of master-slave systems subjected to some nonlinear perturbations and mixed neutral and discrete time-varying delays is investigated based on an H ∞ performance condition. By introducing a descriptor technique, using Lyapunov-Krasovskii functional and a suitable change of variables, new required sufficient conditions are established in terms of delay-dependent linear matrix inequalities to synthesize the resid…
Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues.
2022
Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas similar to 30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be est…
Modalitātes lietojums tiešsaistes laikrakstu rakstos Lielbritānijā un ASV par politiskām tēmām
2020
Iepriekšējie pētījumi par modalitātes lietojumu laikrakstu rakstos atklāja, ka žurnālisti mēdz ietekmēt lasītājus un sniegt faktu subjektīvu interpretāciju, kad tiek gaidīts objektīvs notikumu atspoguļojums. Tāpēc šī darba mērķis bija analizēt modalitātes lietojumu septiņpadsmit tiešsaistes laikrakstu rakstos divos Lielbritānijas un divos ASV laikrakstos par Brexit. Pētījumā izmantotās metodes ir diskursa analīze un statistiskā analīze. Rezultāti liecina, ka visvairāk lietotais modālais darbības vārds abu valstu laikrakstos ir will, kas izteica pārliecības nozīmi ar pierādījumu palīdzību, un norādīja, ka priekšroka tiek dota patiesībai. Pārējie modālie darbības vārdi would un could dominēja…
Piebildes izpausmes veidi lietišķajā angļu rakstu valodā
2015
Bakalaura darbs pēta galvenos piebildes izpausmes veidus angļu valodā, kas ir atrodami darījumu angļu valodas atskaitēs,jo īpaši, novērtējuma atskaitēs. Pētījuma mērķis ir noteikt darījumu atskaitēs atrodamos ziņošanas darbības vārdus un izpētīt to nozīmi un pielietojumu. Pētījuma teorētiskā daļa ietver literatūras apskatu par runas ziņojumiem, to funkcijām, kā arī literatūras pārskatu par piebildes izpausmes veidiem. Tālāk darbā tiek detalizētāk aplūkoti tādi piebildes izpausmes veidi kā darbības vārdi. Pēcāk tiek salīdzināti dažādu autoru piedāvātie piepildes izpausmes veidi. Otrajā daļā darba autors apraksta pētījumā pielietotās metodes un darba norises gaitu. Kā arī, darba gaita tiek sī…
Crowdfunding in the Cultural Industries
2020
AbstractCultural production has stood at the forefront of crowdfunding adoption representing some of the first crowdfunding campaigns on record. This development emerged as part of comprehensive value chain reconfigurations in the cultural sector, which were triggered by the advent of digitalization on the one hand and the downsizing in public funds on the other. As a result, the emerging phenomenon here labelled as ‘cultural crowdfunding’ (CCF) has captured the imagination of researchers and practitioners. The study of CCF is of high relevance, as it presses creators to strike a balance between the commercial and the non-commercial, the economic and the cultural outcomes, as well as the au…
How Performant Are the Premium Companies Listed on BSE? A Financial Performance Analysis from a Value Creation Perspective
2018
In order to analyze the potential of listed companies, the scientific literature suggests modern indicators that are built using value creation concepts. The attention of specialists, both theoreticians and practitioners, is directed towards the approach of company’s performance based on the created value. Traditional management based on analyzing and interpreting accounting data from financial statements has proved a reduced capacity to evaluate and express in a clear and precise manner the real performances of companies. Over time, the financial ratios used to quantify the value created by companies as expression of their performance were in multiple forms, becoming more and more comprehe…