Search results for "EXPRESSION"
showing 10 items of 5168 documents
Espressione scritta per lo sviluppo della creatività e della capacità critica in Università
2018
La scoperta della scrittura ha svincolato il pensiero dal contesto e lo ha reso capace di interpretare i messaggi linguistici a partire solamente dalla parola e dalle loro connessioni logiche, ragionamento logico che permette argomentazioni più ampie, categorizzazioni più sistematiche, codificazioni sempre più precise. L’attività di scrittura favorisce l’acquisizione di schemi cognitivi utili alla strutturazione logica del pensiero, promuove abilità di pianificazione e di organizzazione delle proprie idee in modo rigoroso, contribuisce allo sviluppo di capacità espressive formali. I saggi sono stati corretti usando “la Guida per la correzione dei temi” di Calonghi e Boncori (2006). Dalla co…
A sequence motif enriched in regions bound by the Drosophila dosage compensation complex
2010
Abstract Background In Drosophila melanogaster, dosage compensation is mediated by the action of the dosage compensation complex (DCC). How the DCC recognizes the fly X chromosome is still poorly understood. Characteristic sequence signatures at all DCC binding sites have not hitherto been found. Results In this study, we compare the known binding sites of the DCC with oligonucleotide profiles that measure the specificity of the sequences of the D. melanogaster X chromosome. We show that the X chromosome regions bound by the DCC are enriched for a particular type of short, repetitive sequences. Their distribution suggests that these sequences contribute to chromosome recognition, the genera…
Global patterns of sequence evolution in Drosophila.
2007
This article is available from: http://www.biomedcentral.com/1471-2164/8/408
Expression of the human XPB/ERCC-3 excision repair gene-homolog in the sponge Geodia cydonium after exposure to ultraviolet radiation.
1998
Abstract The marine demosponge Geodia cydonium encodes a gene, termed GCXPB , which displays 62% identity to the human XPB/ERCC-3 gene that specifically corrects the repair defect in xeroderma pigmentosum and in Cockayne's syndrome. The cDNA was isolated and characterized the deduced aa sequence, XPB_GEOCY, with the calculated size of 91,541 Da comprises the characteristic domains found in the related helicases. Phylogenetic tree analysis revealed that the sponge sequence is grouped to the metazoan related XPB/ERCC-3 polypeptides. Northern Blot analyses have been performed with sponge samples collected at different depths, thus exposed to different intensities of UV sunlight in the field. T…
Cutting Edge: An IL-17F-CreEYFP Reporter Mouse Allows Fate Mapping of Th17 Cells
2009
Abstract The need for reporter lines able to faithfully track Th17 cells in vivo has become an issue of exceptional importance. To address this, we generated a mouse strain in which Cre recombinase is expressed from the IL-17F promoter. Crossing the IL-17F-Cre allele to a conditional enhanced yellow fluorescent protein (EYFP) reporter mouse yielded the IL-17F-CreEYFP strain, in which IL-17F expression is twinned with EYFP in live IL-17F-expressing cells. Although we demonstrate that IL-17F expression is restricted to CD4+ T cells during experimental autoimmune encephalomyelitis, IL-17F-CreEYFP CD8 T cells robustly expressed IL-17F in response to TGF-β, IL-6, and IL-23. Fate mapping of IL-17…
Immunomodulatory effects of dietary β-1,3-glucan from Euglena gracilis in rainbow trout (Oncorhynchus mykiss) immersion vaccinated against Yersinia r…
2012
Abstract Potential immunostimulatory effects of orally administered β-glucan were investigated in combination with immersion vaccination against enteric redmouth disease caused by Yersinia ruckeri in rainbow trout (Oncorhynchus mykiss). A linear, unbranched and pure (purity ≥98%) β-1,3-glucan (syn. paramylon) from the alga Euglena gracilis was applied at an inclusion level of 1% β-glucan in feed administered at a rate of 1% biomass day−1 for 84 consecutive days. Fish were vaccinated after two weeks of experimental feeding and bath challenged with live Y. ruckeri six weeks post-vaccination. Blood and head kidney were sampled at day 0, 13 (1 day pre-vaccination), 15, 55, 59 (day 3 post-challe…
Genetic sex determination and sex-specific lifespan in tetrapods – evidence of a toxic Y effect
2020
ABSTRACTSex-specific lifespans are ubiquitous across the tree of life and exhibit broad taxonomic patterns that remain a puzzle, such as males living longer than females in birds and vice versa in mammals. The prevailing “unguarded-X” hypothesis (UXh) explains this by differential expression of recessive mutations in the X/Z chromosome of the heterogametic sex (e.g., females in birds and males in mammals), but has only received indirect support to date. An alternative hypothesis is that the accumulation of deleterious mutations and repetitive elements on the Y/W chromosome might lower the survival of the heterogametic sex (“toxic Y” hypothesis). Here, we report lower survival of the heterog…
Zinc Finger Proteins in Neuro-Related Diseases Progression
2021
Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, zinc finger proteins can regulate gene expression at the transcriptional and translational levels. In terms of neurological diseases, numerous studies have shown that many zinc finger proteins are associated with neurological diseases. The purpose of this review is to summarize the types and roles of zinc finger proteins in neuropsychiatric disorders. We will describe the structure and classification of zinc finger proteins, then focus on the pathophysiological role of zinc finge…
Alternative splicing regulation by Muscleblind proteins: from development to disease.
2011
Regulated use of exons in pre-mRNAs, a process known as alternative splicing, strongly contributes to proteome diversity. Alternative splicing is finely regulated by factors that bind specific sequences within the precursor mRNAs. Members of the Muscleblind (Mbl) family of splicing factors control critical exon use changes during the development of specific tissues, particularly heart and skeletal muscle. Muscleblind homologs are only found in metazoans from Nematoda to mammals. Splicing targets and recognition mechanisms are also conserved through evolution. In this recognition, Muscleblind CCCH-type zinc finger domains bind to intronic motifs in pre-mRNA targets in which the protein can e…
The Importance of the Variability of Leucocyte Zinc Transporter 8 (ZnT8) Gene Expression
2023
The variability of ZnT8 expression in leukocytes develops in patients witha geneticpredisposition to this condition and it decreases with age. Greater intercellular zinc accumulation may potentially provoke increased levels of its expression, as a support mechanism in zinc homeostasis. The occurrence of ZnT8 antibodies (ZnT8A) may result in leukocyte dysfunction, which is dependent i.a. on the level of ZnT8 expression. The same correlation can be observed in non-pancreatic tissues. ZnT8A occur in approximately 16.5% of research participants without any diabetes symptoms and the frequency of their occurrence decreases with age as well. The occurence of variability of ZnT8 expression in leuko…