Search results for "EXPRESSION"
showing 10 items of 5168 documents
Effects of ectopic expression of NGAL on doxorubicin sensitivity.
2012
Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are important in the transport of iron. NGAL also has important biological functions involved in immunity and inflammation as well as responses to kidney damage. NGAL expression has also been associated with certain neoplasia and is important in the metastasis of breast cancer. Many advanced cancer patients have elevated levels of NGAL in their urine and it has been proposed that NGAL may be a prognostic indicator for certain cancers (e.g. breast, brain, and others). NGAL exp…
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
2013
Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborat…
Maturation of Epidermal Langerhans Cells In Vitro Is Accompanied by Downregulation of 4F2 (CD98) as Determined by Differential Display
1998
Following short-term culture, Langerhans cells mature morphologically and functionally into potent immunostimulatory cells. As regulation of gene expression accompanies this maturation process, it is likely that differentially expressed genes are involved in the maturation events. Using the recently described method of differential display, we generated cDNA expression patterns starting with mRNA of murine epidermal Langerhans cells isolated either directly (fLC) or following 3 d cultivation (cLC). Five hundred putative differentially expressed cDNA fragments were recovered from the gel. For a part of the fragments differential expression was confirmed by dot blot and Southern hybridization…
The oxidative capacity of skeletal muscle : effects of genotype, high-fat diet and physical activity
2016
Environmental factors modulating cold tolerance, gene expression and metabolism in Drosophila montana
2011
ALS-RELATED FUS PROTEIN IS MISLOCALIZED TO CYTOPLASM AND RECRUITED INTO STRESS GRANULES IN FIBROBLASTS OF ASYMPTOMATIC FUS P525L MUTATION CARRIERS
Symptoms onset in Amyotrophic Lateral Sclerosis (ALS) occur when over 70% of motor neurons is already lost, suggesting a relatively long pre-symptomatic phase. The description of several genes linked to ALS (e.g., SOD1, FUS, TARDP, C9orf72) has now allowed identification of pre-symptomatic carriers. These pre-symptomatic (or even preclinical) carriers can be followed up with the aim to identify the very early clinical disease-related changes or a valuable biomarker. These efforts seem at present the best approach for the implementation of an early symptomatic therapy or for the disease prevention. In this work, we studied the expression of FUS protein in cultured skin fibroblasts from pre-s…
Comparative transcriptomics of albino and warningly‐coloured caterpillars
2021
Abstract Coloration is perhaps one of the most prominent adaptations for survival and reproduction of many taxa. Coloration is of particular importance for aposematic species, which rely on their coloring and patterning acting as a warning signal to deter predators. Most research has focused on the evolution of warning coloration by natural selection. However, little information is available for color mutants of aposematic species, particularly at the genomic level. Here, I compare the transcriptomes of albino mutant caterpillars of the aposematic wood tiger moth (Arctia plantaginis) to those of their full sibs having their distinctive orange‐black warning coloration. The results showed >29…
Suoliston mikrobit ja fyysinen suorituskyky
2021
Suolistoamme asuttava miljardilukuinen mikrobiyhteisö osallistuu fysiologiaamme monin tavoin. Se kykenee esimerkiksi hajottamaan ravinnosta yhdisteitä, joihin omat entsyymimme eivät pure. Poikittaistutkimuksissa on löydetty ihmisen fyysisen suorituskyvyn ja suolistomikrobien välisiä yhteyksiä. Liikunta-aktiivisuus näyttäisi lisäävän tiettyjen terveysvaikutteisten suolistomikrobien määrää. Pitkittäistutkimuksista tekemämme systemoitu katsaus osoittaa, että liikunta vaikuttaa ihmisten suolistomikrobeihin, mutta tulokset ovat ristiriitaisia. Yleisimmin keskikuormittava kestävyysliikunta on aiheuttanut eniten muutoksia suolistossa, mutta tähänastinen tutkimus on painottunut iäkkäisiin, ylipaino…
Estimating Stress in Online Meetings by Remote Physiological Signal and Behavioral Features
2022
Work stress impacts people’s daily lives. Their well-being can be improved if the stress is monitored and addressed in time. Attaching physiological sensors are used for such stress monitoring and analysis. Such approach is feasible only when the person is physically presented. Due to the transfer of the life from offline to online, caused by the COVID-19 pandemic, remote stress measurement is of high importance. This study investigated the feasibility of estimating participants’ stress levels based on remote physiological signal features (rPPG) and behavioral features (facial expression and motion) obtained from facial videos recorded during online video meetings. Remote physiological sign…
Hysteretic Systems Subjected to Delta Correlated Input
1994
The paper deals with the evaluation of the probabilistic response of a single degree of freedom elastic-perfectly plastic system subjected to a delta correlated input process. The probabilistic characterisation of the response is here obtained by considering the accumulated plastic deformations as a compound homogeneous Poisson process independent of the external input. In this case the former can be considered as an external noise acting on the linear system. A closed form solution is also obtained and the analytic expression is compared with the customary Monte-Carlo method.