Search results for "Earing"
showing 10 items of 867 documents
Speech perception outcomes after cochlear implantation in prelingually deaf infants: The Western Sicily experience
2013
Objectives: To describe audiometric characteristics and speech perception performances of prelingually deaf Sicilian children after cochlear implantation; to identify the influence of cochlear implant (CI) user and family's characteristics on speech recognition and intelligibility outcomes. Methods: Twenty-eight infants with a congenital or acquired hearing impairment and implanted before the 3rd year of life were studied; all children suffered from bilateral sensorineural hearing loss (SNHL) with evidence of lack of hearing aids benefit and no evidence of intellectual disability. The study of the main characteristics associated with CI user and family's profile was performed with a clinica…
Deficient membrane integration of the novel p.N14D-GJB2mutant associated with non-syndromic hearing impairment
2006
Mutations in GJB2, the gene encoding for the Gap Junction protein Connexin 26 (Cx26), have been established as the major cause of hereditary, non-syndromic hearing impairment (HI). We report here the identification of a novel point mutation in GJB2, c.40A>G [p.N14D], detected in compound heterozygosity with the c.35delG mutation in two brothers with moderate non-syndromic sensorineural HI. The mother who carried one wildtype and a p.N14D allele displayed normal hearing. The mutation leads to substitution of the neutral amino acid asparagine (N) by the negatively charged aspartic acid (D) at amino acid number 14, a position that is conserved among Cx26 of different organisms and among many o…
Born to dance but beat deaf: A new form of congenital amusia
2011
Humans move to the beat of music. Despite the ubiquity and early emergence of this response, some individuals report being unable to feel the beat in music. We report a sample of people without special training, all of whom were proficient at perceiving and producing the musical beat with the exception of one case (“Mathieu”). Motion capture and psychophysical tests revealed that people synchronized full-body motion to music and detected when a model dancer was not in time with the music. In contrast, Mathieu failed to period- and phase-lock his movement to the beat of most music pieces, and failed to detect most asynchronies of the model dancer. Mathieu’s near-normal synchronization with a…
Comparative studies on check-bite and central-bearing-point method for the remounting of complete dentures
1995
Thirty-six complete dentures were remounted both with check-bite as well as central-bearing-point (CBP) registration. The mandibular or denture position was registered in the condylar area three times with each method. Two independent operators carried out the registrations. One half of patients had their occlusion equilibrated according to the check-bite registration, the other half in the central-bearing-point position. After individual determination of the hinge axis the upper dentures were mounted by a face-bow transfer into a Dentatus articulator. A total of six registrations was performed and repeatedly compared in the condylar area in three dimensions using a computer supported measu…
Interrogator intonation and memory encoding performance.
2019
Based on recent findings that interrogator intonation can enhance interrogative suggestibility during recall phases, the present study tested influences of interrogator intonation on memory performance even as early as at the encoding stage. We experimentally manipulated interrogator intonation during encoding of a story to be recalled in immediate and delayed subsequent memory tests (Experiment 1, N = 50). As expected, a symmetrically structuring vs. an isolating-emphasizing speaking style generally increased the amount of freely recalled details. In a more fine-grained experiment (N = 50), we additionally manipulated emphasized story details and tested recall rates for peripheral, neutral…
Electrical brain activity and facial electromyography responses to irony in dysphoric and non-dysphoric participants
2020
We studied irony comprehension and emotional reactions to irony in dysphoric and control participants. Electroencephalography (EEG) and facial electromyography (EMG) were measured when spoken conversations were presented with pictures that provided either congruent (non-ironic) or incongruent (ironic) contexts. In a separate session, participants evaluated the congruency and valence of the stimuli. While both groups rated ironic stimuli funnier than non-ironic stimuli, the control group rated all the stimuli funnier than the dysphoric group. N400-like activity, P600, and EMG activity indicating smiling were larger after the ironic stimuli than the non-ironic stimuli for both groups. Further…
A novel DFNB1 deletion allele supports the existence of a distant cis-regulatory region that controls GJB2 and GJB6 expression
2010
Contains fulltext : 87760_1.pdf (author's version ) (Open Access) Contains fulltext : 87760_2.pdf (Publisher’s version ) (Closed access) Eleven affected members of a large German-American family segregating recessively inherited, congenital, non-syndromic sensorineural hearing loss (SNHL) were found to be homozygous for the common 35delG mutation of GJB2, the gene encoding the gap junction protein Connexin 26. Surprisingly, four additional family members with bilateral profound SNHL carried only a single 35delG mutation. Previously, we demonstrated reduced expression of both GJB2 and GJB6 mRNA from the allele carried in trans with that bearing the 35delG mutation in these four persons. Usin…
Self-reported hearing difficulties and changes in life-space mobility among community-dwelling older adults: a Two-year follow-Up study
2015
Background Life-space mobility reflects individuals’ actual mobility and engagement with society. Difficulty in hearing is common among older adults and can complicate participation in everyday activities, thus restricting life-space mobility. The aim of this study was to examine whether self-reported hearing predicts changes in life-space mobility among older adults. Methods We conducted a prospective cohort study of community-dwelling older adults aged 75–90 years (n = 848). At-home face-to-face interviews at baseline and telephone follow-up were used. Participants responded to standardized questions on perceived hearing at baseline. Life-space mobility (the University of Alabama at Birmi…
PanCareLIFE
2018
Aims: Survival after cancer diagnosed during childhood or adolescence continues to improve with new treatments and supportive therapies. Optimal long-term care requires that risks to vulnerable organs are clearly defined and translated into guidelines that are implemented into practice. PanCareLIFE is a pan-European consortium that addresses survivorship issues comprising fertility, hearing impairment and quality of life. This article describes the scientific basis of PanCareLIFE's studies.Methods: PanCareLIFE involves 17 partner institutions from eight European countries, with additional 11 data providers from five other countries. Study designs and methods include molecular genetic, cohor…
Benefit of hearing aid use in the elderly: the impact of age, cognition and hearing impairment
2018
Il beneficio protesico e il ruolo delle abilità cognitive, dell’età e del deficit uditivo nel paziente anziano.Questo studio analizza il beneficio protesico in un campione di soggetti anziani (n = 102, età media 81,1 anni), indagando il ruolo svolto dall’età, dal deficit uditivo e dalle abilità cognitive. Il beneficio protesico è stato valutato sia come miglioramento delle caratteristiche audiometriche con protesi (in termini di soglie tonali e soglie di percezione del parlato in quiete e nel rumore) sia come diminuzione della percezione della disabilità e dell’handicap dovuti alla ipoacusia. Sono state valutate diverse abilità cognitive, tra cui la memoria a breve termine, le funzioni esec…