Search results for "Edge"
showing 10 items of 3866 documents
Five Challenges for Benefits Management in Complex Digitalisation Efforts – and a Research Agenda to Address Current Shortcomings
2019
Over the past decades a number of benefits realisation (BR) frameworks have been developed. The benefits management model (BMM) is considered to be the most widely adopted and is often seen as a reference for good practice in digitalisation efforts in single organisations. However, this literature provides little support for complex, inter‑organisational efforts. This is problematic, considering that digitalisation increasingly involves multiple organisations. To explore this gap, we studied the phenomenon in a Norwegian inter‑organisational eHealth effort. Based on a qualitative study involving 50 interviews, observations and document analyses, we identify five distinct challenges and sugg…
Intellectual capital reporting: A knowledge tool to coordinate a group of regional non-profit organisations
2017
Whilst many organizations worldwide have stopped disclosing Intellectual Capital (IC), to the best of our knowledge, the only longstanding NPO still measuring, managing and reporting its IC is a large Italian non-profit organization (NPO), ANPAS Piemonte. The main aim of the article is thus to investigate the reasons why ANPAS Piemonte continues to deal with IC, to examine the determinants of this choice, the costs and the benefits management gets from IC measurement, management and reporting. In other words, the paper aims to explore the intellectual capital (IC) reporting process from an internal, managerial point of view. The paper employ a case study methodology to address its aim, and …
Digital Resilience to Normal Accidents in High-Reliability Organizations
2021
Digital technologies play a dual role on organizational resilience. On one side, digital systems introduce new technological risks. On the other side, digital systems increase the performances in response to hazardous accidents. Normal Accident Theory (NAT) and High-Reliability Organization (HRO) provide useful ground to explain the dynamics of digital resilience. However, the two theories have been either used as alternatives or with one theory dominating the other. We posit that to fully understand digital resilience we need to integrate NAT and HRO concepts instead of using them in isolation. We conduct a bibliometric analysis to identify major themes and application domains characterizi…
Knowledge, attitudes, and practices about homelessness and willingness-to-pay for housing-first across 8 European countries: a survey protocol
2018
Contains fulltext : 200223.pdf (Publisher’s version ) (Open Access) Background: Most European countries report rising numbers of people experiencing homelessness. For those with mental disorders, interventions are centered on achieving mental health and drug rehabilitation alongside housing readiness, often to the detriment of access to housing. Notwithstanding, more European countries are investing in a new model, Housing First (HF), which postulates immediate access to permanent housing with no initial requirements for treatment. While results of the European HF programs are published on individual-level data, little is known about the opinions of the general population about homelessness…
Deep learning and process understanding for data-driven Earth system science
2017
Machine learning approaches are increasingly used to extract patterns and insights from the ever-increasing stream of geospatial data, but current approaches may not be optimal when system behaviour is dominated by spatial or temporal context. Here, rather than amending classical machine learning, we argue that these contextual cues should be used as part of deep learning (an approach that is able to extract spatio-temporal features automatically) to gain further process understanding of Earth system science problems, improving the predictive ability of seasonal forecasting and modelling of long-range spatial connections across multiple timescales, for example. The next step will be a hybri…
High variability of edge effects on forest vegetation diversity
2012
National audience; The influence of edges on vegetation diversity in forest fragments is an important issue for biodiversity conservation because of the large part of temperate woodlands concerned. In numerous empirical studies, a general pattern has been identified; it is described as two zones: the edge where plant distribution is linked to the distance from the forest border, the core area where the variability of vegetation is not linked to this distance. We present results of a study aiming at measuring the edge effects on vegetation in forest fragments in south-western France and at identifying potential factors of their variability. Vegetation was sampled in 28 transects constituted …
Plant Pigments: Properties, Analysis, Degradation
2005
Publisher Summary This chapter discusses the molecular structures, the general physicochemical properties of plant pigments, and the mechanisms involved in pigment degradation. The invasive and noninvasive methods used for pigment analysis, including the mechanisms involved in pigment degradation, are reviewed. The chapter presents different analytical methods that can be used to identify pigments. All the methods are invasive techniques that are time consuming and often expensive. To reduce sampling and analytical costs, and to speed up the analyses, noninvasive analytical procedures have been developed with the aim to characterize the pigment content of samples, and in the case of food pr…
The small heat-shock protein α B-crystallin is essential for the nuclear localization of Smad4: impact on pulmonary fibrosis
2014
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by the proliferation of myofibroblasts and the accumulation of extracellular matrix (ECM) in the lungs. TGF-β1 is the major profibrotic cytokine involved in IPF and is responsible for myofibroblast proliferation and differentiation and ECM synthesis. αB-crystallin is constitutively expressed in the lungs and is inducible by stress, acts as a chaperone and is known to play a role in cell cytoskeleton architecture homeostasis. The role of αB-crystallin in fibrogenesis remains unknown. The principal signalling pathway involved in this process is the Smad-dependent pathway. We demonstrate here that αB-crystallin is stron…
A ciliopathy complex builds distal appendages to initiate ciliogenesis
2021
ABSTRACTCells inherit two centrioles, the older of which is uniquely capable of generating a cilium. Using proteomics and super-resolved imaging, we identified a module which we term DISCO (DIStal centriole COmplex). DISCO components CEP90, MNR and OFD1 underlie human ciliopathies. This complex localized to both distal centrioles and centriolar satellites, proteinaceous granules surrounding centrioles. Cells and mice lacking CEP90 or MNR did not generate cilia, failed to assemble distal appendages, and did not transduce Hedgehog signals. Disrupting the satellite pools did not affect distal appendage assembly, indicating that it is the centriolar populations of MNR and CEP90 that are critica…
Providing a general framework about spin-off success factors in complex environments
2018
Spin-off organisations are the main vehicle for knowledge transfer from universities and/or high educational institutions (HEIs) to the economic system. Spin-off firms are complex phenomenon which requires particular conditions to its creation, survival and development. In the last decade, the scientific debate recognised the importance and the role of spin-off organisations, but the main factors and actors that impact on their creation, survival and development are not always clear. This paper aims to fill this gap, shedding light on this black box. In a first step, this research will identify the main 'success factors' for creation of spin-offs. In the second step, the relationship betwee…