Search results for "Editor"

Chemokine receptor CXCR4-prognostic factor for gastrointestinal tumors

2008

To review the implication of CXCR4 for gastrointestinal cancer, a "Pubmed" analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers. Search terms applied were "cancer, malignoma, esophageal, gastric, colon, colorectal, hepatic, pancreatic, CXCR4, SDF-1alpha, and SDF-1beta". CXCR4 expression correlated with dissemination of diverse gastrointestinal malignomas. The CXCR4 ligand SDF-1alpha might act as "chemorepellent" while SDF-1beta might act as "chemorepellent" for CTLs, inducing tumor rejection. The paracrine expression of SDF-1alpha was furthermore closely associated with neoangiogenesis. CXCR4 and its ligands influence the disseminat…

Future Research in Graves' Orbitopathy: From Priority Setting to Trial Design Through Patient and Public Involvement

2015

Graves' orbitopathy (GO) is a disfiguring autoimmune condition, which can sometimes cause blindness (1). The disease has profound effects on quality of life (2), psychological health (3), and socioeconomic status (4). Progress in understanding and treating this disease has been slow. However, recent advances include delineation of plausible immunological mechanisms (5), development of an animal model (6), and publication of randomized studies defining the role and limitations of intravenous steroids (7), rituximab (8,9), and selenium (10). Yet, some of this knowledge remains to be translated into improvement in clinical care. Access of patients to specialist treatments is patchy and seems t…

Missing Evidences in Cancer Genetics: The Retinoblastoma Paradigm

2008

BACKGROUND: Retinoblastoma (Rb) is the most common primary malignant intraocular tumour in childhood. The "two hit" theory, formulated by Knudson in 1971 to explain the variegated clinical expression of the disease, led to the discovery of the so called tumour suppressor genes and the identification of the Rb1 as the prototype of such genes. Mutations of the Rb1 gene are now commonly believed to be the "cause" retinoblastoma, although epidemiological, clinical, and biological evidences argue against it. MATERIAL/METHODS: The Authors have performed a systematic review of available data concerning clinical and diagnostic aspects of retinoblastoma, including molecular genetics. Meta analysis o…

QUI SONT LES "GATEKEEPERS" DE LA RECHERCHE EN COMPTABILITÉ ?

2008

International audience; Plusieurs auteurs ont avancé l'idée que la recherche en comptabilité serait dominée par une "élite" constituée d'individus provenant d'un petit nombre d'universités et qui contrôlerait la production scientifique en monopolisant les fonctions éditoriales au sein des principales revues académiques. Le but de ce papier est de tester cette assertion en examinant la composition des editorial boards de 35 revues de comptabilité. Les résultats révèlent un assez faible niveau de concentration, tant au niveau des individus que des universités d'appartenance, ce qui ne confirme pas l'hypothèse de l'existence d'une telle élite. Ils montrent en revanche l'extrême domination des …

Comments to the paper "do we really need new medical information about the Turin Shroud?".

2015

Abstract Following the interesting arguments raised in a recent letter to the editor, about a paper recently published in this journal, the authors are happy to take a cue from them to clarify some facts that have not been sufficiently treated for space. After a description of the methods used, arguments regarding a blunt trauma on the right shoulder with consequent dislocation, the position of the hands on the pubis with brachial plexus injury, and the wrist nailing that caused retracted thumbs are discussed in detail.

The Rationale of the WHO Document on Risk communication and community engagement (RCCE) readiness and response to the Severe Acute Respiratory Syndro…

2020

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A tribute to Juan Rosai

2021

On July 7, 2020 the world of Surgical Pathology lost one of the brightest minds ever: Prof. Juan Rosai.It certainly happened to many of us while approaching a difficult case to exclaim: - This is a case for Juan Rosai! This simple expression synthesizes the legend that was created around him.Those who knew him personally were  undoubtedly amazed by his diagnostic insight, exceptional memory and organizational skills.However, his vast culture and passions were not limited to medicine, but ranged to music, literature and the world of sports, especially football.We worked with him in his last years of activity and want to share with the communities of pathologists our warm feelings about this …

Tra testo e scena

2014

Socs3 induction by PPARγ restrains cancer-promoting inflammation

2013

The presence of proinflammatory cytokines in the tumor microenvironment can support further growth of established cancers. Docosahexaenoic acid (DHA), a peroxisome proliferator-activated receptor-gamma (PPARγ) ligand, has been shown to suppress inflammation and limit tumor progression in vivo. Are the anticancer properties of DHA relying on its ability to prevent inflammation? If so, what are the molecular links between the anti-inflammatory properties of DHA and its anticancer effects? DHA is an n-3 polyinsaturated fatty acid mainly found in fish oil that was shown to contribute to inflammation resolution by preventing the release of proinflammatory mediators in vivo.1 DHA has also been as…

Revista electrónica de investigación y evaluación educativa

2014

Resumen basado en el de la publicación Título, resumen y palabras clave en inglés y español Se analiza el estatus del género existente en los equipos o consejos editoriales de las revistas científicas españolas de Educación. A priori, se indaga el estatus de la eminencia científica en el campo de la Educación; con el fin de detectar los posibles sesgos de género. Como análisis complementario se considera la nacionalidad o procedencia de los miembros de los consejos editoriales de las revistas de Educación. El hallazgo principal testimonia un fuerte sesgo contra las mujeres cuando éstas son consideradas editoras. Valencia ESP