Search results for "Effectivene"

First-Line Treatments for Extensive-Stage Small-Cell Lung Cancer With Immune Checkpoint Inhibitors Plus Chemotherapy: A Network Meta-Analysis and Cos…

2022

BackgroundImmune checkpoint inhibitors (ICIs) plus chemotherapy were unlikely to be considered cost-effective compared with chemotherapy as the first-line treatment of patients with extensive-stage small-cell lung cancer (ES-SCLC) in China due to its high costs. However, the cost-effectiveness of the comparison between the regimens of ICIs plus chemotherapy were remained unclear yet. The aim of this study was to evaluate the efficacy and cost-effectiveness of ICIs plus chemotherapy as the first-line treatment for ES-SCLC from the perspective of the Chinese healthcare system.MethodsA network meta-analysis (NMA) was conducted to indirect compare the clinical benefits between the ICIs plus che…

Combined TL and 10B-alanine ESR dosimetry for BNCT

2004

The dosimetric technique described in this paper is based on electron spin resonance (ESR) detectors using an alanine-boric compound acid enriched with 1 0 B, and beryllium oxide thermoluminescent (TL) detectors; with this combined dosimetry, it is possible to discriminate the doses due to thermal neutrons and gamma radiation in a mixed field. Irradiations were carried out inside the thermal column of a TRIGA MARK II water-pool-type research nuclear reactor, also used for Boron Neutron Capture therapy (BNCT) applications, with thermal neutron fluence from 10 9 to 10 1 4 n t h cm - 2 . The ESR dosemeters using the alanine-boron compound indicated ESR signals about 30-fold stronger than those…

Dose calculation in biological samples in a mixed neutron-gamma field at the TRIGA reactor of the University of Mainz

2010

To establish Boron Neutron Capture Therapy (BNCT) for non-resectable liver metastases and for in vitro experiments at the TRIGA Mark II reactor at the University of Mainz, Germany, it is necessary to have a reliable dose monitoring system. The in vitro experiments are used to determine the relative biological effectiveness (RBE) of liver and cancer cells in our mixed neutron and gamma fi eld. We work with alanine detectors in combination with Monte Carlo simulations, where we can measure and characterize the dose. To verify our calculations we perform neutron fl ux measurements using gold foil activation and pin-diodes . Material and methods . When L- α -alanine is irradiated with ionizing …

EPR DOSIMETRY IN A MIXED NEUTRON AND GAMMA RADIATION FIELD

2004

Suitability of Electron Paramagnetic Resonance (EPR) spectroscopy for criticality dosimetry was evaluated for tooth enamel, mannose and alanine pellets during the 'international intercomparison of criticality dosimetry techniques' at the SILENE reactor held in Valduc in June 2002, France. These three materials were irradiated in neutron and gamma-ray fields of various relative intensities and spectral distributions in order to evaluate their neutron sensitivity. The neutron response was found to be around 10% for tooth enamel, 45% for mannose and between 40 and 90% for alanine pellets according their type. According to the IAEA recommendations on the early estimate of criticality accident a…

INTERNAL AUDIT: DEFINING, OBJECTIVES, FUNCTIONS AND STAGES

2010

This article aims, through a detailed presentation as to provide clarification for a better understanding of what internal audit definition, objectives, functions and stages of its development mean. It is also exposed a brief history about the emergence and development of internal audit and regulatory framework. I also plan to linking theory and practice by reference to documents used: both the evidence considered and especially those prepared by the auditors in connection with the performance audit and its use in the audit report.

Tehokkuuden subjektiivinen konstruointi julkishallinnon työntekijöiden puheessa – organisaatioestetiikka viitekehyksenä

2020

This study examines the employees’ everyday experiences at work. The goal is to encourage the emancipation from the limitations of rationality cultivating an aesthetic understanding of organizations. It seeks to answer how organization members construct their experiences of efficiency based on the dualism between aesthetic and rationality and how are these constructions related. This study also seeks to ansewer what kind of dynamics discourses on effectiviness deliver and maintain. The empirical data is obtained by interviews with public sector employees and interpreted using deconstructive analysis presented by David Boje. Based on the research interviews the strong reliance on rationality…

Zgoda dłużnika na cesję wierzytelności, następnie potrąconej, a problem bezskuteczności czynności upadłego

2022

Celem badawczym pracy jest analiza relacji pomiędzy przepisami ustawy – Prawo upadłościowe, regulującymi bezskuteczność czynności prawnych, w tym tryb dochodzenia roszczeń pauliańskich, jeżeli przelew wierzytelności względem przyszłego upadłego, wymagający zgody dłużnika, następnie stanowi faktyczną podstawę do dokonania potrącenia przez cesjonariusza. Innymi słowy, jest to problem granic ochrony interesów masy upadłości w postępowaniu upadłościowym. Problem ten ma zarówno doniosłość teoretyczną, jak również znaczenie dla praktyki prawa o niewypłacalności. W pracy bronione jest zapatrywanie, że zgoda przyszłego upadłego na cesję wierzytelności nie jest bezskuteczną czynnością prawną. Funkcj…

Consumption behavior of eco-friendly products and applications of ICT innovation

2021

The purchase of eco-friendly products is encouraged by the governments due to its contributions to the sustainable development of the environment. It is therefore important to examine factors influencing the purchase of eco-friendly products. Based on the attitude-behavior-context (ABC) theory, this paper constructs a conceptual model, which explores how a consumer’s perceived effectiveness affects individuals’ purchase of eco-friendly products. In details, this paper attempts to examine the mediating role of consumption attitude of eco-friendly products, as well as the moderating effect of applications of information and communication technologies (ICT) innovation. Moreover, by building a …

Paniikkihäiriön kognitiivis-konstruktiivinen ryhmämuotoinen terapia : behavioraalisesta näkökulmasta kohti konstruktiivista näkemystä

1997

Investigating the success of ERP systems in Pakistan : end-users' perspective

2016

The global business environment is changing rapidly, and organisations from developing countries such as Pakistan have to re-engineer their business processes to meet the challenges of increased competition and rising customer expectations. Enterprise resource planning (ERP) systems intend to deliver many benefits, such as business automation, reduced operating costs, accurate demand forecasts, better decision-making and improved customer service. However, organisations adopting ERP systems encounter many types of problems that may lead to failures in processes, expectations and interactions. In order to address these failures, researchers have identified the critical success factors in the…