Search results for "Effects"
showing 10 items of 2634 documents
Antiproliferative effects of bioaccessible fractions of honeys from Sicilian black honeybee (Apis mellifera ssp. sicula) on human colorectal carcinom…
2021
The aim of this study was to evaluate the antiproliferative activity of bioaccessible fractions (BFs) obtained by the internationally standardized INFOGEST static digestion method to Sicilian honeys of three distinct floral origins (Sulla, Thistle and Dill) and the Manuka honey (gold standard), and to compare their effects based on total polyphenol content (TPC). Differentiated CaCo-2 cells (intestinal-like) and non-differentiated CaCo-2 and HCT-116 colonic tumour-like cells were incubated for 24 h with BFs of honeys to test viability, apoptosis, mitochondrial membrane potential (MMP), ROS and cell cycle. TPC after digestion ranked in the following order: Dill > Thistle > Sulla > M…
Characterization and DNA-binding properties of GRF, a novel monomeric binding orphan receptor related to GCNF and betaFTZ-F1
1999
0014-2956 (Print) Comparative Study Journal Article Research Support, Non-U.S. Gov't; A PCR approach has been used to isolate, from Bombyx mori, a cDNA encoding a novel orphan receptor (GRF) that is most closely related to Bombyx betaFTZ-F1 and to the vertebrate germ cell nuclear factor. The major GRF mRNA is detected in most tissues as an 8-kb transcript whose amount follows the circulating ecdysteroid concentration with a delay. The expression pattern of GRF is similar to that of the Bombyx homologue of the Drosophila early-late gene DHR3, and precedes that of betaFTZ-F1 in all stages and tissues examined. The GRF protein is thus likely to be required in many tissues, but in a temporally …
Early life stress programming of NG2+ glia transcriptome alters functional properties of voltage gated sodium (Nav) channels and cognitive performance
2020
AbstractThe precise mechanisms underlying the detrimental effects of early life stress (ELS) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of stress-related brain function. Here, we have investigated the impact of ELS on a glial subpopulation with unique properties in brain homeostasis, the NG2+ cells. ELS shifted the NG2+ transcriptome towards more mature stages, and these transcriptional effects were dependent on stress-induced glucocorticoids. The functional relevance of one candidate gene, Scn7a, could be confirmed by an increase…
The heterogeneity of services and the differential effects on business and territorial innovation
2011
The innovative results of firms depend upon their specific characteristics and their ability to weave together their competences with the innovative resources in their environment. Different approaches have underlined the importance of location and the context of business innovation. In particular, the existence of knowledge intensive services (KIS) enables firms to create and commercialise new processes, products and services. However, KIS can present substantial differences in their capacity to contribute to innovation. This article examines the relationship between KIS and business innovation and establishes a KIS typology in order to pinpoint its effects on business innovation. The resu…
A Textual and Visual Analysis of the Intrinsic Value Dimensions of Romania: Towards a Sustainable Destination Brand
2020
This work examines the projected image of Romania as an emerging tourism destination. Computed content-analysis was applied to the photos, text and video materials promoted online in Romania&rsquo
Influence of social stress on the rewarding effects of cocaine
2016
Les relacions socials són un procés crucial en el desenvolupament de l’ésser humà, i en altres espècies socials que viuen en jerarquies socials complexes. L’entorn i l’ambient en el qual es desenvolupa un individu és fonamental, ja que tindrà un gran impacte sobre el seu benestar, el manteniment de la salut i la seua supervivència (Kessler i cols., 2010). La resposta a l'estrés és un factor clau en el manteniment de l'homeòstasi i la salut de l'individu. Aquesta dependrà de la interacció amb l’entorn i l’activitat de certs sistemes regulatoris de l’organisme, com són el sistema nerviós simpàtic i l’eix hipotàlem-hipofisari-adrenal (HPA) (Stratakis i Chrousos, 1995). Diferents tipus d'estrés…
Innovative pragmatic codes in Ugandan English : a relevance-theoretic account
2013
Published version of an article in the journal: Argumentum. Also available from the publisher at: http://argumentum.unideb.hu/2013-anyagok/bisingoma.pdf Open access The paper investigates innovative pragmatic codes in Ugandan English within the conceptual framework of Relevance Theory (cf. Sperber & Wilson 1986, Wilson & Sperber 2004). Wilson & Sperber (2004) state that an utterance is optimally relevant if it is worth the hearer’s processing effort, and if it is compatible with the speaker’s linguistic abilities and preferences. The reasoning behind these tenets of Relevance Theory can be used to account for the pervasive use of many expressions peculiar to Ugandan English. For example, in…
Steel fibre and transverse reinforcement effects on the behaviour of high strength concrete beams
2012
An experimental program was carried out to investigate the influence of fibre reinforcement on the mechanical behaviour of high strength reinforced concrete beams. Eighteen beams, loaded in fourpoint bending tests, were examined by applying monotonically increasing controlled displacements and recording the response in terms of load-deflection curves up to failure. The major test variables were the volume fraction of steel fibres and the transverse steel amount for two different values of shear span. The contribution of the stirrups to the shear strength was derived from the deformations of their vertical legs, measured by means of strain gauges. The structural response of the tested beams …
Strain gradient plasticity, strengthening effects and plastic limit analysis
2010
Abstract Within the framework of isotropic strain gradient plasticity, a rate-independent constitutive model exhibiting size dependent hardening is formulated and discussed with particular concern to its strengthening behavior. The latter is modelled as a (fictitious) isotropic hardening featured by a potential which is a positively degree-one homogeneous function of the effective plastic strain and its gradient. This potential leads to a strengthening law in which the strengthening stress, i.e. the increase of the plastically undeformed material initial yield stress, is related to the effective plastic strain through a second order PDE and related higher order boundary conditions. The plas…
Influence of double infections on the induction of thymidine kinase by UV-irradiated herpes simplex virus types 1 and 2 and pseudorabies virus
1975
Simultaneous infection of primary rabbit kidney cells with HSV type 1 TK+ and a TK- strain results in a mutual influence of both viruses on the induction of thymidine kinase (TK). TK+ virus has an enhancing and TK- virus a depressing effect on TK induction by a superinfecting TK+ virus. The enzyme induction depends on the ratio of multiplicities of both viruses. The mutual influence on TK induction depends further on the time of addition of the superinfecting virus: the effect of the second virus can still be observed when given 6 hours after primary infection. Identical phenomena can be observed using combinations with HSV type 2 or Pseudorabies viruses. The ability of HSV to induce TK is …