Search results for "Effects"
showing 10 items of 2634 documents
Non-specific Effects of Vaccines Illustrated Through the BCG Example: From Observations to Demonstrations
2018
Epidemiological studies regarding many successful vaccines suggest that vaccination may lead to a reduction in child mortality and morbidity worldwide, on a grander scale than is attributable to protection against the specific target diseases of these vaccines. These non-specific effects (NSEs) of the Bacille Calmette-Guérin (BCG) vaccine, for instance, implicate adaptive and innate immune mechanisms, with recent evidence suggesting that trained immunity might be a key instrument at play. Collectively referring to the memory-like characteristics of innate immune cells, trained immunity stems from epigenetic reprogramming that these innate immune cells undergo following exposure to a primary…
More is not always better—non-linear effects in crowdfunding
2019
Abstract This research focuses on crowdfunding project features and its relation with the success of this project. The main purpose is to improve probability of success of crowdfunding projects. One can argue that “more is always better” resulting in attempts of daily updates. Contrarily, backers may be weary of numerous updates to work through, indicating a possible wear-out effect, implying the existence of an optimal level of updates. Our preliminary results show that previous research, built upon linear modeling, widely ignores important aspects of the relationship between key variables. We therefore picked six key variables that were previously marked as success drivers in crowdfunding…
The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2.
2015
The NG2 proteoglycan is characteristically expressed by oligodendrocyte progenitor cells (OPC) and also by aggressive brain tumours highly resistant to chemo- and radiation therapy. Oligodendrocyte-lineage cells are particularly sensitive to stress resulting in cell death in white matter after hypoxic or ischemic insults of premature infants and destruction of OPC in some types of Multiple Sclerosis lesions. Here we show that the NG2 proteoglycan binds OMI/HtrA2, a mitochondrial serine protease which is released from damaged mitochondria into the cytosol in response to stress. In the cytosol, OMI/HtrA2 initiates apoptosis by proteolytic degradation of anti-apoptotic factors. OPC in which NG…
Usefulness of biomarkers as intermediate endpoints in health risks posed by occupational lead exposure
2015
The article concerns potential harmful effects of exposure to lead. Although the occurrence of severe lead poisoning has receded in several countries, occupational exposure resulting in moderate and clinically symptomatic toxicity is still common. An earlier and precise characterization of an individual response is obligatory in order to assess the possible risks for human health. Biomarkers may fill important gaps in the path from exposure to a disease. Specifically speaking, emerging (DNA double strand breaks and telomeric DNA erosion) and validated (micronuclei induction and chromosomal aberrations) biomarkers of genotoxicity seem to provide evidence for the assessment of molecular and c…
EU Cultural Security Law in an Educational Context
2021
Cultural security is a comprehensive notion that has gained much attention in the recent cultural heritage debates. In terms of the EU, it encapsulates cultural heritage destruction and protection in armed conflicts, post-war cultural heritage management, restitution, illicit traffic of cultural property, cultural diversity, and intercultural dialogue. The article aims to present how cultural security matters appear in the EU legal system and policy. The authors argue that cultural security is present in different policies regarding cultural property and the fight against illicit trafficking, as well as in EU external cultural relations. Digitization in the cultural sector constitutes a cha…
Carbon emissions by Ssouth american companies: driving factors for reporting decisions and emissions reduction
2018
In the last decade, companies have started to disclose information on carbon emissions. To our knowledge, this is the first paper to look into this phenomenon in South America, which is a very important geographical area regarding climate change because of the local nature and developing economies. This paper explores the relationships between some corporate variables and two important decisions: (i) whether to report carbon emissions, and (ii) the impact on the evolution of carbon emissions. Logit and linear panel data models are used to determine the driving factors for decisions (i) and (ii). Our results show that regarding the carbon reporting decision, a company&rsquo
Mayors, Using Cultural Expenditure in An Opportunistic Way Improves the Chances of Re-Election, but Do Not Do It: Revisiting Political Budget Cycles
2020
This article analyzes whether expenditure on the provision of merit goods, culture, health, education, and sports, by local governments, in medium-sized cities (between 20,000 and 100,000 inhabitants) is tied to the electoral cycle
Transformative Policies for the Social and Solidarity Economy: The New Generation of Public Policies Fostering the Social Economy in Order to Achieve…
2020
The United Nations Agenda 2030 has recognized that Social Economy (SE) entities play an important role in achieving the Sustainable Development Goals (SDG). In order to maximize the impact of the SE, governments have recently deployed new policies regarding these entities. The objective is to understand the context of policy change that has allowed these policies to emerge, their main characteristics and the critical factors in their construction and implementation. Successful policy cases in Europe and Spain have been studied. Qualitative data have been collected through key policy documents, experts, and focus groups. As a main finding, the study shows that this new model of policies exhi…
Penyagolosa Trails: From Ancestral Roads to Sustainable Ultra-Trail Race, between Spirituality, Nature, and Sports. A Case of Study
2019
[EN] The organization of an open-air sporting event involves a series of challenges. People are drawn by the desire to do sport, preferably in close contact with nature, so as to complement healthy lifestyles, and in search of air purity. Sporting organizations are increasingly searching for new locations that do not only attract athletes, but spectators and companions too. Races in natural parks provide the additional benefit of doing sport in a unique space, usually a transmitter of simplicity, pure air, and tranquillity. Organizing a mountain race in a natural park implies some issues. These are areas of great environmental richness that must be protected. Natural parks are places of ind…
Towards a sustainable leader-follower relationship: constructive dissensus, organizational virtuousness and happiness at work (haw)
2020
This paper examines how leaders and followers can interact positively under complex and bounded conditions. For this purpose, this paper conceptualizes and measures the concept of constructive dissensus. Constructive dissensus relates to a mutual understanding leading to a situation of coregulation. In addition, the relationship between constructive dissensus and happiness at work is examined on the basis of affective events theory. Furthermore, the mediating role of organizational virtuousness is assessed. Through structural equation modeling, a multilevel analysis was performed. Data from 130 bank branches and 606 employees were gathered. The results reveal a direct effect of constructive…