Search results for "Egan"

Effets Biologiques d'extraits Aqueux de Peganum Harmala ( L. ) ( Zygophyllaceae ) sur la Mortalité et le Développement Larvaire de Drosophila Melanog…

2013

High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibition.

2011

OBJECTIVE Because of confounding factors, the effects of dietary n-3 polyunsaturated fatty acids (PUFA) on type 1 diabetes remain to be clarified. We therefore evaluated whether fat-1 transgenic mice, a well-controlled experimental model endogenously synthesizing n-3 PUFA, were protected against streptozotocin (STZ)-induced diabetes. We then aimed to elucidate the in vivo response at the pancreatic level. RESEARCH DESIGN AND METHODS β-Cell destruction was produced by multiple low-doses STZ (MLD-STZ). Blood glucose level, plasma insulin level, and plasma lipid analysis were then performed. Pancreatic mRNA expression of cytokines, the monocyte chemoattractant protein, and GLUT2 were evaluate…

SINTESI E ATTIVITÀ PROAPOPTOTICA SU LINEE CELLULARI TUMORALI UMANE DI COMPLESSI DI Pt (II) CON LEGANTI AZOLICI FLUORURATI

2014

Búsqueda de nuevos ingredientes bioactivos en obesidad para el diseño de nuevos alimentos funcionales, en base a la demanda del consumidor

2015

La innovación tecnológica en materia de salud ha sido un campo ampliamente estudiado y sigue siendo un foco de interés económico reiterado y prioritario. La alimentación es uno de los hábitos que más repercusión tienen en el estado de salud y en la prevención de determinadas enfermedades lo que influye cada vez más en los hábitos de compra de los consumidores (Niva M., 2007, Bech-Larsen T et al., 2007, Jones PJ et al., 2007, Van Kleef E et al., 2002). Un trastorno de la alimentación puede generar obesidad y con ello el desarrollo de múltiples complicaciones asociadas a la misma. En los últimos años, la Organización Mundial de la Salud (WHO., 2014 y 2015) ha venido alertando de la gran crisi…

Maintenance of the intestinal tube in Caenorhabditis elegans: the role of the intermediate filament protein IFC-2.

2008

The Caenorhabditis elegans intestinal lumen is surrounded by a dense cytoplasmic network that is laterally attached to the junctional complex and is referred to as the endotube. It localizes to the terminal web region which anchors the microvillar actin filament bundles and is particularly rich in intermediate filaments. To examine their role in intestinal morphogenesis and function, C. elegans reporter strains were generated expressing intestine-specific CFP-tagged intermediate filament polypeptide IFB-2. When these animals were treated with dsRNA against intestinal intermediate filament polypeptide IFC-2, the endotube developed multiple bubble-shaped invaginations that protruded into the …

Identification and characterisation of the dopamine receptor II from the cat flea Ctenocephalides felis (CfDopRII)

2006

International audience; G protein-coupled receptors (GPCRs) represent a protein family with a wide range of functions. Approximately 30% of human drug targets are GPCRs, illustrating their pharmaceutical relevance. In contrast, the knowledge about invertebrate GPCRs is limited and is mainly restricted to model organisms like Drosophila melanogaster and Caenorhabditis elegans. Especially in ectoparasites like ticks and fleas, only few GPCRs are characterised. From the cat flea Ctenocephalides felis, a relevant parasite of cats and dogs, no GPCRs are known so far. Thus, we performed a bioinformatic analysis of available insect GPCR sequences from the honeybee Apis mellifera, the mosquito Anop…

Cytology of Thamnidium elegans Link. II. Distribution and behaviour of nuclei in hyphae, sporangiophores and sporangiospores.

1976

The resting nuclei in hyphae, sporangiophores and sporangiospores of sporangia and sporangiola of Thamnidium elegans consist of a large centrals nucleolus and a shell of chromatin surrounding the nucleolus. Division of the nucleus in hyphae and sporangiospores is achieved by elongation and constriction.

Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protei…

2008

Recent studies provide evidence that wild-type Cu/Zn-superoxide dismutase (SOD1(hWT)) might be an important factor in mutant SOD1-mediated amyotrophic lateral sclerosis (ALS). In order to investigate its functional role in the pathogenesis of ALS, we designed fusion proteins of two SOD1 monomers linked by a polypeptide. We demonstrated that wild-type-like mutants, but not SOD1(G85R) homodimers, as well as mutant heterodimers including SOD1(G85R)-SOD1(hWT) display dismutase activity. Mutant homodimers showed an increased aggregation compared with the corresponding heterodimers in cell cultures and transgenic Caenorhabditis elegans, although SOD1(G85R) heterodimers are more toxic in functiona…

Designer membraneless organelles enable codon reassignment of selected mRNAs in eukaryotes.

2019

How to make an organelle in eukaryotes A key step in the evolution of complex organisms like eukaryotes was the organization of specific tasks into organelles. Reinkemeier et al. designed an artificial, membraneless organelle into mammalian cells to perform orthogonal translation. In response to a specific codon in a selected messenger RNA, ribosomes confined to this organelle were able to introduce chemical functionalities site-specifically, expanding the canonical set of amino acids. This approach opens possibilities in synthetic cell engineering and biomedical research. Science , this issue p. eaaw2644

An asynchronous covert channel using spam

2012

AbstractCurrent Internet e-mail facilities are built onto the foundation of standard rules and protocols, which usually allow a considerable amount of “freedom” to their designers. Each of these standards has been defined based on a number of vendor specific implementations, in order to provide common inter-working procedures for cross-vendor communication. Thus, a lot of optional and redundant information is being exchanged during e-mail sessions, which is available to implement versatile covert channel mechanisms.This work exploits this possibility by presenting a simple but effective steganographic scheme that can be used to deploy robust secret communication through spam e-mails. This s…