Search results for "Elea"

Ottimizzazione delle tecniche di imaging per lo studio ed il monitoraggio delle lesioni epatiche in pazienti con malattie vascolari del fegato.

2014

Enzyme-responsive intracellular-controlled release using silica mesoporous nanoparticles capped with ε-poly-L-lysine.

2014

The synthesis and characterization of two new capped silica mesoporous nanoparticles for controlled delivery purposes are described. Capped hybrid systems consist of MCM-41 nanoparticles functionalized on the outer surface with polymer epsilon-poly-L-lysine by two different anchoring strategies. In both cases, nanoparticles were loaded with model dye molecule [Ru(bipy)(3)](2+). An anchoring strategy involved the random formation of urea bonds by the treatment of propyl isocyanate-functionalized MCM-41 nanoparticles with the lysine amino groups located on the epsilon-poly-L-lysine backbone (solid Ru-rLys-S1). The second strategy involved a specific attachment through the carboxyl terminus of…

Protein delivery based on uncoated and chitosan-coated mesoporous silicon microparticles

2011

Mesoporous silicon is a biocompatible, biodegradable material that is receiving increased attention for pharmaceutical applications due to its extensive specific surface. This feature enables to load a variety of drugs in mesoporous silicon devices by simple adsorption-based procedures. In this work, we have addressed the fabrication and characterization of two new mesoporous silicon devices prepared by electrochemistry and intended for protein delivery, namely: (i) mesoporous silicon microparticles and (ii) chitosan-coated mesoporous silicon microparticles. Both carriers were investigated for their capacity to load a therapeutic protein (insulin) and a model antigen (bovine serum albumin) …

Transdermal and Skin-Targeted Drug Delivery

1997

Background: The application of therapeutic agents to the skin addresses three general objectives: (a) the treatment of a variety of dermatologic diseases; (b) the “targeted” delivery of drugs to deeper subcutaneous tissues, with a concomitant reduction in systemic exposure; and (c) socalled transdermal administration to elicit a systemic pharmacologic effect. Objective: Recently, significant progress towards all three goals has been recorded and the level of research and development activity remains high. We aim to discuss these advances from mechanistic and clinical standpoints. Results: For the topical treatment of skin disease, novel vehicles (e.g., stabilized, supersaturated systems and…

CORROSION RESISTANCE OF DIFFERENT STAINLESS STEEL GRADES IN FOOD AND BEVERAGE INDUSTRY

2020

Polysaccharide/polyaminoacid composite scaffolds for modified DNA release.

2009

Abstract In this work composite polymeric films or sponges, based on hyaluronic acid (HA) covalently crosslinked with α,β-poly(N-2-hydroxyethyl)(2-aminoethylcarbamate)- d , l -aspartamide (PE), have been prepared and characterized as local gene delivery systems. In particular, HA/PE scaffolds have been loaded with PE/DNA interpolyelectrolyte complexes, employing PE as a macromolecular crosslinker for HA and as a non-viral vector for DNA. In vitro studies showed that HA/PE films and sponges have high compatibility with human dermal fibroblasts and they give a sustained DNA release, whose trend can be easily tailored by varying the crosslinking ratio between HA and PE. Electrophoresis analysi…

Fatigue crack growth in welds based on a V-notch model for the short crack propagation at the toe

2018

Abstract This work presents a new fatigue crack growth prediction model for non-load-carrying fillet welded steel joints. For this joint configuration the fatigue cracks will emanate from the weld toe region. Due to the presence of a V-notch in this region the crack initiation point becomes a point of singularity for the stress field. This may in many cases make it difficult to determine the Stress Intensity Factor Range (SIFR) for small cracks by conventional methods based on Linear Elastic Fracture Mechanics (LEFM). The present approach solves this problem by using the Energy Release Rate (ERR) to determine the SIFR in the small crack growth regime. The model is fitted to crack growth cur…

Experimental Tests of Fatigue Induced Delamination in Gfrp and Cfrp Laminates

2007

This work deals with the experimental analysis of the delamination phenomena in various composite materials under different loading conditions. Quasi-static and fatigue tests are performed on specimens made of glass-fibre reinforced plastic (GFRP) and carbon-fibre reinforced plastic (CFRP). In particular, under both quasi-static and fatigue loading, single fracture modes I and II (using standard DCB and ENF test configurations) and mixed modes I+II (using the MMB test configuration) with several mode mixtures, have been analysed. Further experiments of delamination growth with mode mixture that varies with the crack length, will be performed.

Thermodynamics and continuum fracture mechanics for nonlocal-elastic plastic materials

2002

Nonlocal elasticity is used as an improved elasticity model which engenders no crack-tip stress singularities and thus makes applicable the classical stress-based failure criteria. Considering nonlocal-elastic plastic materials exposed to softening by particle decohesion in a process surface and to subsequent surface separation by fracture, fracture mechanics is addressed within the framework of irreversible internal-variable thermodynamics in the hypothesis of small strains and arbitrary (but sufficiently regular) fracture surface (crack surface plus process surface). The state equations and the energy dissipation densities are derived for the bulk material and for the process surface, for…

Mixed mode energy release rates for bonded composite joints

2011

Abstract: Analytical formulae developed by Luo and Tong (2009) to determine the mixed mode strain energy release rates of laminated and co-cured composite structures and joints are reviewed. The effects of varying loading conditions and geometries on the mode mixity found analytically are investigated via a parametric study. A critical evaluation of the analytical formulae indicates that the formulae are robust in calculating the total strain energy release rate, but may underestimate the mode II component compared with the finite element analysis and experimental results. Possible reasons for this discrepancy are discussed, including the effect of stress concentrations and singularities at…