Search results for "Elements"
showing 10 items of 799 documents
The distributions of protein coding genes within chromatin domains in relation to human disease.
2019
Abstract Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wide interaction maps shows functional consequences that extend the initial thought of an efficient DNA packaging mechanism: gene regulation, DNA repair, chromosomal translocations and evolutionary rearrangements seem to be only the peak of the iceberg. One key concept emerging from this research is the topologically associating domains (TADs) whose functional role in gene regulation and their association with disease is not fully untangled. Resul…
cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel
2020
Abstract Background Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understanding of how the effects of genetic variants affect different molecular mechanisms to determine gut immunocompetence is still limited. Results To address this, we perform a systems genetics analysis of the gut transcriptomes from 38 DGRP lines that were orally infected with Pseudomonas entomophila. We identify a large number of condition-specific, expression quantitative trait loci (local-eQTLs) with infection-specific ones located …
Mobile genetic element proliferation and gene inactivation impact over the genome structure and metabolic capabilities of Sodalis glossinidius, the s…
2010
Abstract Background Genome reduction is a common evolutionary process in symbiotic and pathogenic bacteria. This process has been extensively characterized in bacterial endosymbionts of insects, where primary mutualistic bacteria represent the most extreme cases of genome reduction consequence of a massive process of gene inactivation and loss during their evolution from free-living ancestors. Sodalis glossinidius, the secondary endosymbiont of tsetse flies, contains one of the few complete genomes of bacteria at the very beginning of the symbiotic association, allowing to evaluate the relative impact of mobile genetic element proliferation and gene inactivation over the structure and funct…
DESIGN PRINCIPLES OF COLLABORATIVE LEARNING SPACE CONNECTING TEACHERS AND REFUGEE CHILDREN - A DESIGN SCIENCE RESEARCH STUDY
2020
Learning the German language is one of the most critical challenges for refugee children in Germany. It is a prerequisite to allow communication and integration into the educational system. To solve the underlying problem, we conceptualized a set of principles for the design of language learning systems to support collaboration between teachers and refugee children, using a Design Science Research approach. The proposed design principles offer functional and non-functional requirements of systems, including the integration of open educational resources, different media types to develop visual and audio narratives that can be linked to the cultural and social background. This study also illu…
Uz autentisku materiālu balstītu audio kursa izstrāde un ieviešana skolēnu klausīšanās prasmju pilnveidei angļu valodā 11. klasē
2022
Praktiskās klausīšanās prasmju trūkums skolēnu vidū ir viena no biežāk novērojamām problēmām angļu valodas stundās. Dažādi testēšanas elementi tiek izmantoti ar mērķi novērtēt klausīšanas prasmes, tomēr patiesais klausīšanās izpratnes process netiek veidots. Skolēni nezina iemeslus, kāpēc, klausoties, viņi pieļāva īpašas kļūdas, un tas noved pie tā, ka viņiem nav iespēju izstrādāt savas stratēģijas, kā izvairīties no kļūdu pieļaušanas. Stundās nav pietiekami daudz iespēju iesaistīties aktīvā klausīšanās procesā un nav iespējams praktiski izmantot piezīmes, kas gūtas, klausoties, un darba autore to uzskata par vienu no faktoriem, kas skolēniem rada grūtības klausīties. Pētījuma mērķis bija i…
An Euler-Bernoulli beam element with lumped plasticity applied on RC framed structures
2016
Most of existing reinforced concrete structures suffer due to corrosion of steel and concrete degradation. In many cases existing structures reveal to be inadequate to absorb the expected seismic load and need to be rehabilitated according to the in force code. In the worst case some structures have not been designed to absorb horizontal actions. The rehabilitation process begins with the complete knowledge of its geometrical configuration and the evaluation of the vulnerability of the structure to seismic loads. This analysis permits to identify critical zones and to establish focused strengthening actions. A comparison between the behavior of the structure in the current and in the future…
Species and genetic diversity relationships in benthic macroinvertebrate communities along a salinity gradient
2022
Background Species- and genetic diversity can change in parallel, resulting in a species-genetic diversity correlation (SGDC) and raising the question if the same drivers influence both biological levels of diversity. The SGDC can be either positive or negative, depending on whether the species diversity and the genetic diversity of the measured species respond in the same or opposite way to drivers. Using a traditional species diversity approach together with ultra-conserved elements and high throughput sequencing, we evaluated the SGDCs in benthic macrofauna communities in the Baltic Sea, a geologically young brackish water sea characterised by its steep salinity gradient and low species …
Rare‐earth cyclobutadienyl sandwich complexes: Synthesis, structure and dynamic magnetic properties
2018
The potassium cyclobutadienyl [K2{η4‐C4(SiMe3)4}] (1) reacts with MCl3(THF)3.5 (M=Y, Dy) to give the first rare‐earth cyclobutadienyl complexes, that is, the complex anions [M{η4‐C4(SiMe3)4}{η4‐C4(SiMe3)3‐κ‐(CH2SiMe2}]2−, (2M), as their dipotassium salts. The tuck‐in alkyl ligand in 2M is thought to form through deprotonation of the “squarocene” complexes [M{η4‐C4(SiMe3)4}2]− by 1. Complex 2Dy is a single‐molecule magnet, but with prominent quantum tunneling. An anisotropy barrier of 323(22) cm−1 was determined for 2Dy in an applied field of 1 kOe, and magnetic hysteresis loops were observed up to 7 K. nonPeerReviewed
Major and trace elements characterization of atmospheric deposition in volcanic, urban, and industrial areas of Sicily (Italy): preliminary results
2022
The source of chemical elements dissolved in rainwater can be both natural and anthropogenic. A group of trace elements has been recently brought to attention for their possible environmental impacts, the Technology-critical elements (TCEs). The current knowledge about the geochemical cycle of TCEs is still scarce, nevertheless recent studies [e.g. Brugnone et al., 2020] evidenced a contribution from the volcanic activity for some of them (Te, Tl, and REE). Our research aims to produce a geochemical database on major and trace element depositions in different areas of Sicily: a volcanic area (Etna), two urban areas (Palermo, Catania), two industrial areas (Milazzo, Priolo), and a rural moni…