Search results for "Endocrine System"
showing 10 items of 1530 documents
Dental management of patients with endocrine disorders
2010
Introduction: The endocrine system is responsible for hormonal secretion and is closely related to the central nervous system, as it diversifies its functions through the hypothalamus and pituitary glands. It controls physiological processes and maintains homeostasis. The neuroendocrine system is responsible for adaptation to environmental changes. Therefore, in dentistry, it is important to be aware of the risks and difficulties that may arise during the dental management of patients with endocrine disorders, and that visits to the dental clinics often represent a stressful situation. Objectives: To review the literature on oral manifestations and dental management in patients with endocri…
Chronic Spontaneous Urticaria and Type 1 Diabetes Mellitus—Does Quality of Life Impairment Always Reflect Health Danger?
2020
Background and aims: Chronic spontaneous urticaria (CSU) and diabetes mellitus type 1 (T1DM) may compromise the quality of life (QoL). We decided to compare the QoL of T1DM patients to those suffering from CSU. Materials and methods: Sixty-six patients with well-controlled T1DM (male 52%) in the mean age of (SD) 36.3 (11.09) years and 51 patients with CSU (male 33%) in the mean age of (SD) 35.8 (8.53) years were enrolled in this observational study. All the participants completed a Short-Form 36 (SF-36) QoL. Results: The QoL related to social functioning was significantly worse among CSU patients. There were differences related to gender found in the group of patients with T1DM&mdash
Consumption of Thyroid Medications as an Indicator of Increase of Thyroid Morbidity in Latvia from 2011 to 2014
2019
Abstract The most common autoimmune disorders with clinically opposite manifestations are hypothyroidism in Hashimoto’s thyroiditis and hyperthyroidism in Graves’ disease. The healthcare burden of thyroid disease is substantial, resulting in substantial health care costs. The aim of the present analysis is to assess the use of thyroid medications in Latvia from 2011 to 2014 by age and gender. Our study used reimbursed medication prescriptions data, collected by the National Health Service of Latvia. The main indicator was the number of prevalent users of thyroid medications each year from 2011 to 2014, stratified by age and gender. From 2011 to 2014, the number of thyroxine users per 100 00…
Mycotoxin Incidence in Some Fish Products: QuEChERS Methodology and Liquid Chromatography Linear Ion Trap Tandem Mass Spectrometry Approach
2019
The inclusion of vegetal raw materials in feed for fish farming has increased the risk of mycotoxin occurrence in feed, as well as in edible tissues from fish fed with contaminated feed, due to the carry-over to muscle portions. Therefore, the objective of this study was to evaluate the occurrence of 15 mycotoxins in processed fish products, which are commonly consumed, such as smoked salmon and trout, different types of sushi, and gula substitutes. A QuEChERS method was employed to perform the mycotoxin extraction from fish samples. For mycotoxin identification and quantitation, the selected technique was the liquid chromatography-tandem mass spectrometry linear ion trap (LC-MS/MS-LIT). Sm…
Relaxation by urocortin of human saphenous veins
2002
Urocortin, an endogenous peptide structurally related to corticotropin-releasing factor (CRF), has potent cardiovascular effects, suggesting that it may be of significance in cardiovascular regulation. The objective of this study was to analyse the effects of urocortin and its action mechanisms on human blood vessels. To this, 3 mm long segments from human saphenous veins were prepared for isometric tension recording in an organ bath. In the segments at basal resting tone, urocortin did not produce any effect, but in the segments precontracted with endothelin-1 (1 – 10 nM), urocortin (1 pM – 10 nM) produced concentration-dependent relaxation. This relaxation was not modified by the inhibito…
Die C-17-Ketosteroidausschüttung nach Gaben von Äthanol und Wein
1955
Single or repeated doses of wine result in a statistically significant rise of excretion of C-17-Cetosteroids. After application of the same quantity of ethylalcohol, this effect was not seen. These results can be correlated with former observations on the changes of the nuclei-volumes of the zona fasciculata.
Oxytocin receptor ligands: a survey of the patent literature
2008
Background: Oxytocin is produced primarily in hypothalamic neurons and is secreted from the posterior pituitary gland into the circulation in response to stimuli such as suckling, parturition, or stress. Oxytocin functions as an essential component in milk ejection and is among the most potent uterotonic substances known. The oxytocin receptor system supports physiological processes associated with reproduction at several levels. Objective: To characterize and evaluate oxytocin receptor ligands for therapeutic applications. Methods: Analysis of oxytocin analogs and nonpeptide oxytocin receptor ligands, and major applications of these substances. Results/conclusion: Oxytocin receptor ligands…
2,3,7,8-Tetrachlorodibenzo-p-dioxin-Dependent Release from Contact Inhibition in WB-F344 Cells: Involvement of Cyclin A
2002
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent tumor promoter ever tested in rodents. Although it is known that most of TCDD actions are mediated by binding to the aryl hydrocarbon receptor (AhR), the mechanisms leading to tumor promotion still remain to be elucidated. Loss of contact inhibition is one characteristic hallmark in tumorigenesis. In rat liver epithelial WB-F344 cells, TCDD induces a release from contact inhibition, which is manifested by a twofold increase in cell number when TCDD (1 nM for 48 h) is added to confluent cells in the presence of serum, but not when given to exponentially growing or subconfluent, serum-deprived WB-F344 cells. Loss of G1 arrest was a…
Increased bioavailability of oral melatonin after fluvoxamine coadministration*1
2000
Background Fluvoxamine, a selective serotonin reuptake inhibitor, is known to elevate melatonin serum concentrations. It has not been clear whether these effects might be attributed to an increased melatonin production or to an decreased elimination of melatonin. The latter hypothesis was tested by this study. Methods Five healthy male volunteers (one CYP2D6 poor metabolizer) received 5 mg melatonin either with or without coadministration of 50 mg fluvoxamine. Serum concentrations of melatonin and fluvoxamine were assessed from 0 to 28 hours after melatonin intake. Results Coadministration of fluvoxamine, on average, led to an 17-fold higher (P <.05) area under concentration–time curve (AUC…
Effect of mesoglycan on macrorheologic and microrheologic parameters
1992
Abstract Whole blood filtration, mean erythrocyte aggregation, and erythrocyte membrane fluidity were examined in 10 patients with vascular atherosclerotic disease (VAD) and in 15 VAD patients with noninsulin-dependent diabetes mellitus (NIDDM) treated with mesoglycan (100 mg orally twice a day) for 30 days. The red cell membrane transverse fluidity gradient was evaluated in the VAD subjects, and the red cell membrane protein lateral mobility was measured in the VAD subjects with NIDDM. In both groups, mesoglycan treatment was responsible for an increase in erythrocyte membrane fluidity. This finding, which reflects an improvement in the dynamic properties of red cell membrane, assumes part…