Search results for "Enos"

Corsello G, Maresi E, Corrao AM, Dimita U, Lo Cascio M, Cammarata M, Giuffrè L (1992): VATER/VACTERL association: Clinical variability and expanding …

1993

Label Plateforme Stratégique Nationale par la Commission Nationale des Outils Collectifs (CNOC)

2013

Pachyjoenia howa, a new symbiotic parabasalid joeniid flagellate of the termite Postelectrotermes howa

2005

The Joenia-like lophomonad of Postelectrotermes howa is identified by light and electron microscopy as a new genus and species Pachyjoenia howa. Its flagellar area of about 1800 flagella is dome shaped. Basal bodies bear a composite root oriented counterclockwise in addition to the clockwise hook-shaped lamina present in other joeniids. There are four parallel privileged basal bodies. The main parabasal fibre is twisted around the axostyle and splits into several branches bearing Golgi bodies. The axostyle trunk is conspicuous and composed of a bundle of ∼90 small axostyles. There are sausage-shaped bacterial endosymbionts mixed with hydrogenosomes in the cytoplasm and coccoid bacterial end…

Crust–mantle transition and Moho model for Iceland and surroundings from seismic, topography, and gravity data

2005

An increasing data set exists on the nature and thickness of the Iceland crust. This paper relates topography, i.e., elevation and bathymetry (TOP), Bouguer gravity anomalies (BA) and Moho depths to each other to assess the consequences of the “thick crust model” for Iceland in the context of the North Atlantic. Results of regression of TOP and BA vs. Moho depth are converted into “Airy densities” Δρ* (mantle crust density contrasts in the case of ideal Airy isostasy). For Iceland, Δρ* is very low (105±10 kg/m3); for the adjacent continental margins and relicts, it is high and intermediate for the Jan Mayen Ridge. The values are affected by lithosphere cooling and systematic variations of i…

Eel ATPase activity as biomarker of thiobencarb exposure

2003

Abstract European eels ( Anguilla anguilla ) were exposed to a sublethal thiobencarb concentration of 0.22 mg/L in a flow-through system for 96 h. Mg 2+ and Na + –K + adenosine triphosphatase (ATPase) activities were evaluated in gill and muscle tissues at 2, 12, 24, 48, 72, and 96 h of thiobencarb exposure. Gill ATPase activities were rapidly inhibited from 2 h of contact onward. Highest inhibition was registered for Na + , K + -ATPase (85%) from 2 to 12 h. Both Mg 2+ and total ATPase were inhibited (>73%) during the first hours of toxicant exposure. At the end of the exposure period (96 h) ATPase activities were still different from those of the controls (>50%). Significant inhibition was…

Effects of primary- and secondary-treated bleached kraft mill effluents on the immune system and physiological parameters of roach.

2000

The present study was designed to examine, whether, effluents from a modern pulp and paper mill using elemental chlorine-free/total chlorine-free (ECF/TCF) bleaching, exert effects on the immune system of fish and, in addition, to relate these findings to physiological parameters known to be affected by bleached kraft-mill effluents (BKME). Roach (Rutilus rutilus) were exposed in laboratory conditions to primary- or secondary-treated effluent from a pulp and paper mill. In order to study their capability to respond to foreign antigens they were immunised with bovine gamma-globulin (BGG) prior to exposure. The number of anti-BGG antibody-secreting cells (ASC) and the number of immunoglobulin…

The adenine nucleotide content of rat liver during infusions of carbohydrates and polyols

1972

Injection of large doses of fructose, sorbitol, or a mixture of glucose, fructose and xylitol in rats causes a drop of liver ATP, total adenine nucleotides and Pi and a rise of AMP, which is in agreement with data from the literature. These changes are considered as a transient disturbance of homeostasis by compounds which are rapidly phosporylated in the liver. This is confirmed by the fact that during continuous infusion of these and other compounds at doses of 1,5 g · kg−1 · h−1 there was no such change. It is concluded that infusions of fructose or of the other carbohydrates tested with rates not exceeding those recommended for parenteral nutrition (0,5 g · kg−1 · h−1) are not likely to…

Inhibition of gluconeogenesis by extracellular ATP in isolated rat hepatocytes.

1991

The aim of this study was to determine the effect of externally added ATP on gluconeogenesis by isolated hepatocytes from starved rats. High concentrations of extracellular ATP inhibited gluconeogenesis from lactate and pyruvate but not from glycerol or fructose. This inhibition was associated with an increase in intracellular adenosine contents. ADP, AMP, or adenosine but not guanosine 5'triphosphate, inosine 5' triphosphate, or adenine also inhibited gluconeogenesis. alpha, beta-Methylene-ATP, a nonmetabolizable structural analogue of ATP, did not affect the rate of gluconeogenesis. Intracellular ATP levels were increased by externally added ATP or adenosine, but ATP-to-ADP ratios in the…

Design, Synthesis and Biological Evaluation of 7-Chloro-9

2019

Glycogen synthase kinase-3β (GSK-3β) represents a relevant drug target for the treatment of neurodegenerative pathologies including Alzheimer’s disease. We herein report on the optimization of a novel class of GSK-3β inhibitors based on the tofacitinib-derived screen hit 3-((3R,4R)-3-((7-chloro-9H-pyrimido[4,5-b]indol-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile (1). We synthesized a series of 19 novel 7-chloro-9H-pyrimido[4,5-b]indole-based derivatives and studied their structure–activity relationships with focus on the cyanoacetyl piperidine moiety. We unveiled the crucial role of the nitrile group and its importance for the activity of this compound series. A successfu…

Pivotal Advance: Up-regulation of acetylcholine synthesis and paracrine cholinergic signaling in intravascular transplant leukocytes during rejection…

2009

Abstract A new role and source of the old mediator acetylcholine is described, which is produced by graft monocytes and attenuates monocytic ATP-signaling. During acute rejection, large numbers of leukocytes accumulate in the blood vessels of experimental renal allografts. About 70% of them are activated, cytotoxic monocytes that appear to be involved in allograft destruction. ACh exerts anti-inflammatory effects upon monocytes/macrophages and has been proposed to be a key player in neuroimmunological interactions. Its short half-life, however, makes it unlikely that neuronal ACh affects blood leukocytes. Renal transplantation was performed in the allogeneic DA to LEW and in the isogeneic L…