Search results for "Epstein-Barr-Virus"

showing 3 items of 3 documents

A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus

2014

Contains fulltext : 137763.pdf (Publisher’s version ) (Open Access) Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI)=0.76-0.86, Pcombined=3.5 x 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regul…

AdultMaleAdolescent[SDV]Life Sciences [q-bio]TRANSCRIPTION FACTOR E2AGENETIC-ASSOCIATIONGeneral Physics and AstronomyLocus (genetics)Genome-wide association studyHuman leukocyte antigenBiologyGeneral Biochemistry Genetics and Molecular BiologyArticleDISEASEYoung AdultBasic Helix-Loop-Helix Transcription FactorsHumansTOOLGenetic Predisposition to DiseaseAlleleGENOME-WIDE ASSOCIATIONEPSTEIN-BARR-VIRUSGenetic associationAgedGeneticsAged 80 and overRISKMultidisciplinaryCELL-TYPECase-control studyGenetic VariationGeneral ChemistryOdds ratioGenomicsMiddle AgedALLELESHodgkin DiseaseCANCERMalaltia de HodgkinHodgkin lymphoma (HL)GenòmicaGenetic epidemiologyCase-Control StudiesUrological cancers Radboud Institute for Health Sciences [Radboudumc 15]Hodgkin's diseaseChromosomes Human Pair 19Genome-Wide Association Study
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Burkitt lymphoma with a granulomatous reaction: an M1/Th1‐polarised microenvironment is associated with controlled growth and spontaneous regression

2021

Aims Burkitt lymphoma (BL) is an aggressive B-cell lymphoma that, in some instances, may show a granulomatous reaction associated with a favourable prognosis and occasional spontaneous regression. In the present study, we aimed to define the tumour microenvironment (TME) in four such cases, two of which regressed spontaneously. Methods and results All cases showed aggregates of tumour cells with the typical morphology, molecular cytogenetics and immunophenotype of BL surrounded by a florid epithelioid granulomatous reaction. All four cases were Epstein-Barr virus (EBV)-positive with type I latency. Investigation of the TME showed similar features in all four cases. The analysis revealed a p…

MaleEpstein-Barr Virus InfectionsHerpesvirus 4 HumanHistologyAdolescentM1 polarised macrophagesTh1 T cellsExpressionBiologyT-Cell ResponsesVirusPathology and Forensic MedicineProinflammatory cytokineMolecular cytogeneticsOriginImmunophenotypingEBVM1 polarised macrophagehemic and lymphatic diseasesTumor MicroenvironmentmedicineHumansM1 polarized macrophagesAgedInhibitionMacrophagesBurkitt lymphomaBurkitt lymphoma; EBV; In Situ lymphoid neoplasia; M1 polarized macrophages; Microenvironment; Th1 T cells; granulomatous reactionB-CellsGeneral MedicineMiddle AgedTh1 Cellsmedicine.diseaseBurkitt LymphomamicroenvironmentRegressionLymphomain-situ lymphoid neoplasiagranulomatous reactionCancer researchFemaleTherapyCellular immunotherapyInfectionEarly phaseBurkitt lymphoma EBV granulomatous reaction in-situ lymphoid neoplasia M1 polarised macrophages microenvironment Th1 T cellsIn Situ lymphoid neoplasiaEpstein-Barr-VirusHistopathology
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Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients

2017

Abstract The landscape of human papillomavirus (HPV) infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was h…

OncologyOROPHARYNGEAL CANCERHPVCancer Researchmedicine.medical_specialtyEthnic groupUNITED-STATESOriginal Manuscript03 medical and health sciences0302 clinical medicineInternal medicinemedicineP16 IMMUNOHISTOCHEMISTRYHuman papillomavirus030223 otorhinolaryngologyEPSTEIN-BARR-VIRUSE6/E7 MESSENGER-RNAAFRICAN-AMERICANSHUMAN-PAPILLOMAVIRUS TYPE-16IMPROVED SURVIVALbusiness.industryPOTENTIALLY MALIGNANT DISORDERSHead and neck cancerHPV infectionCancerOrvostudományokGeneral Medicinemedicine.diseaseRacial ethnic3. Good healthPooled analysis030220 oncology & carcinogenesisSmoking statusSettore MED/31 - OTORINOLARINGOIATRIASQUAMOUS-CELL CARCINOMAEgészségtudományokbusiness
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