Search results for "Erk"
showing 10 items of 2599 documents
Energy Efficient Scheduling in Content Distribution Collaborative Mobile Clusters
2020
Most of the existing literatures on green communications aimed to improve the energy efficiency at the base station or data server. However, in order to fully experience high rate broadband multimedia services, prolonging the battery life of user equipment is also critical for the mobile terminals, especially for the smartphone users. In this work, we investigate the problem of designing a content distribution mobile platform named collaborative mobile clusters (CMC) via user cooperation to reduce the energy consumption at the terminal side. Specifically, given numbers of users interested in downloading a common content from the operator, both centralized and distributed user grouping and s…
GDL90fuzz: Fuzzing - GDL-90 Data Interface Specification Within Aviation Software and Avionics Devices–A Cybersecurity Pentesting Perspective
2022
As the core part of next-generation air transportation systems, the Automatic Dependent Surveillance-Broadcast (ADS-B) is becoming very popular. However, many (if not most) ADS-B devices and implementations support and rely on Garmin’s GDL-90 protocol for data exchange and encapsulation. In this paper, we research GDL-90 protocol fuzzing options and demonstrate practical Denial-of-Service (DoS) attacks on popular Electronic Flight Bag (EFB) software operating on mobile devices. For this purpose, we specifically configured our own avionics pentesting platform. and targeted the popular Garmin’s GDL-90 protocol as the industry-leading devices operate on it. We captured legitimate traffic from …
Investigating elementary school students’ text-based argumentation with multiple online information resources
2020
In this study, we explored how elementary school students used multiple information resources in responding to a text-based argumentation task asking them to research a set of online texts in order to state and justify their stance on a controversial health-related issue. Results showed that most students took a stance that was consistent with the majority of the information resources that they read, that they mainly drew on more reliable resources in their written task products, and that they justified their stance by providing one or more supporting reasons. Students relied much more on copying and paraphrasing content from the online resources than on integrating information within and a…
Polycystin-1 downregulation induces ERK-dependent mTOR pathway activation in a cellular model of psoriasis
2018
Psoriatic plaques tend to localize to the knees and elbows, areas that are particularly subject to mechanical stress resulting from bending and friction. Moreover, plaques often develop at sites of mechanical trauma or injury (Koebner phenomenon). Nevertheless, mechanotransduction has never been linked to psoriasis. Polycystins (polycystin-1, PC1; polycystin-2, PC2) are mechanosensitive molecules that function as key regulators of cellular mechanosensitivity and mechanotransduction. The aim of this in vitro study was to investigate the role of polycystins in the development of psoriasis. We showed that PC1 knockdown in HaCaT cells led to an elevated mRNA expression of psoriasis-related biom…
Non-small cell lung cancer (NSCLC), EGFR downstream pathway activation and TKI targeted therapies sensitivity: Effect of the plasma membrane-associat…
2017
Adenocarcinoma of Non-Small Cell Lung Cancer (NSCLC) is a severe disease. Patients carrying EGFR mutations may benefit from EGFR targeted therapies (e.g.: gefitinib). Recently, it has been shown that sialidase NEU3 directly interacts and regulates EGFR. In this work, we investigate the effect of sialidase NEU3 overexpression on EGFR pathways activation and EGFR targeted therapies sensitivity, in a series of lung cancer cell lines. NEU3 overexpression, forced after transfection, does not affect NSCLC cell viability. We demonstrate that NEU3 overexpression stimulates the ERK pathway but this activation is completely abolished by gefitinib treatment. The Akt pathway is also hyper-activated upo…
GIS-data related route optimization, hierarchical clustering, location optimization, and kernel density methods are useful for promoting distributed …
2019
Currently, geographic information system (GIS) models are popular for studying location-allocation-related questions concerning bioenergy plants. The aim of this study was to develop a model to investigate optimal locations for two different types of bioenergy plants, for farm and centralized biogas plants, and for wood terminals in rural areas based on minimizing transportation distances. The optimal locations of biogas plants were determined using location optimization tools in R software, and the optimal locations of wood terminals were determined using kernel density tools in ArcGIS. The present case study showed that the utilized GIS tools are useful for bioenergy-related decision-maki…
(1670-1675) Proposals to conserve the names Bellidiastrum , Berkheya , Euryops , Notobasis , Picnomon and Urospermum (Compositae ) against six generi…
2005
La Chiesa Madre a Gibellina. Quarant'anni dal progetto alla realizzazione
2013
I quarant’anni trascorsi tra il progetto della Chiesa Madre di Gibellina e la sua consacrazione ai Santi Diego e Scolastica hanno trasformato l’architettura di Ludovico Quaroni e Luisa Anversa in un osservatorio privilegiato per poter valutare il dibattito contemporaneo sulle città di nuova fondazione e sulle chiese. La Chiesa Madre è un’architettura dal significato urbano esemplare, che, al tempo stesso, ha generato alcune perplessità in merito ai suoi aspetti liturgici. Infatti, sembra che Ludovico Quaroni, noto architetto di chiese, abbia proposto, a Gibellina, una sintesi fra arte, architettura e urbanistica rivolgendosi più a tutti i cittadini universalmente, che non alle specificità d…
Geografia: dialogo trE generazioni
2020
Il contributo fa parte di un volume dedicato a Girolamo Cusimano e curato dai suoi collaboratori. In esso, in particolare, si ricostruisce una parte delle vicende accademiche riguardanti Girolamo Cusimano e si presenta il lavoro "I geografi e la realtà culturale", pubblicato nel 1990 per i tipi di Flaccovio (Palermo). The contribution is part of a volume dedicated to Girolamo Cusimano and edited by his collaborators. In it, in particular, part of the academic events concerning Girolamo Cusimano are reconstructed and the work "Geographers and cultural reality", published in 1990 for the types of Flaccovio (Palermo), is presented.
Generalist invasion in a complex lake food web
2023
Invasive species constitute a threat not only to native populations but also to the structure and functioning of entire food webs. Despite being considered as a global problem, only a small number of studies have quantitatively predicted the food web-level consequences of invasions. Here, we use an allometric trophic network model parameterized using empirical data on species body masses and feeding interactions to predict the effects of a possible invasion of Amur sleeper (Perccottus glenii), on a well-studied lake ecosystem. We show that the modeled establishment of Amur sleeper decreased the biomasses o ftop predator fishes by about 10%–19%. These reductions were largely explained by inc…