Search results for "Erosa"

La (indimostrata) relazione causale tra Thimerosal ed autismo infantile: revisione della letteratura scientifica e osservazione casistica

2009

Effectiveness and Safety of Ustekinumab in Ulcerative Colitis: Real-world Evidence from the ENEIDA Registry

2021

Abstract Background and Aims The development programm UNIFI has shown promising results of ustekinumab in ulcerative colitis [UC] treatment which should be confirmed in clinical practice. We aimed to evaluate the durability, effectiveness, and safety of ustekinumab in UC in real life. Methods Patients included in the prospectively maintained ENEIDA registry, who received at least one intravenous dose of ustekinumab due to active UC [Partial Mayo Score [PMS]>2], were included. Clinical activity and effectiveness were defined based on PMS. Short-term response was assessed at Week 16. Results A total of 95 patients were included. At Week 16, 53% of patients had response [including 35% o…

Come sonare oggi la musica del passato? Prassi esecutive della musica antica.

2009

Vengon considerate tre fonti: il papiro "Arciduca Ranieri"(III sec. a.C.) contenente sette versi, con notazione melica, dell'antistrofe del primo stasimo dell'Oreste (408 a.C.) di Euripide; la Stele di Sicilo (I/II sec. d. C.); il trittico fiammingo (1460 circa) di Roger van der Weyden, conservato nel duomo di Polizzi Generosa, nella cui tavola centrale quattro angeli – attorno alla Madonna in trono con Gesù bambino – stanno eseguendo il mottetto "Ave regina coelorum, mater regis angelorum" del compositore inglese Walter Frye: due cantano e due suonano.

Desarrollo de formulaciones de liberación controlada para enfermedades inflamatorias

2022

Las enfermedades inflamatorias con componente autoinmune de la piel y del tracto gastrointestinal, como son la psoriasis y la dermatitis atópica y la enfermedad inflamatoria intestinal, respectivamente, son enfermedades prevalentes que necesitan mejorar su tratamiento. La ciclosporina A es un fármaco inmunosupresor que ha demostrado ser efectivo para el tratamiento de enfermedades autoinmunes, pero también sus efectos adversos a nivel sistémico. En el caso de las enfermedades cutáneas, la administración por vía tópica de este fármaco aportaría grandes ventajas como la posibilidad de actuar a nivel local y evitar efectos sistémicos. Sin embargo, la ciclosporina A presenta un tamaño molecular…

Neuropsychological performance 10 years after immunization in infancy with thimerosal-containing vaccines

2009

OBJECTIVE. Thimerosal, a mercury compound used as a preservative in vaccines administered during infancy, has been suspected to affect neuropsychological development. We compared the neuropsychological performance, 10 years after vaccination, of 2 groups of children exposed randomly to different amounts of thimerosal through immunization. METHODS. Children who were enrolled in an efficacy trial of pertussis vaccines in 1992–1993 were contacted in 2003. Two groups of children were identified, according to thimerosal content in vaccines assigned randomly in the first year of life (cumulative ethylmercury intake of 62.5 or 137.5 μg), and were compared with respect to neuropsychological outcome…

Ecology of Cryptomonas at the chemocline of a karstic sulfate-rich lake

2001

In a study from October 1989 to January 1992, a dense population ofCryptomonas cf. erosa (maximum density 38 000 cells mL–1) consistently developed at the chemocline of Lake Arcas, central Spain,where sharp physical and chemical gradients occurred during stratification. This population developed following the establishment of vertical water stratification and declined when the lake was near autumnal mixis. Population growth in situ, attributable to photosynthetic adaptation to low light intensities rather than to phagotrophy, causes these algal maxima. The population densities and net growth rates of C. cf. erosa in situ were influenced by the coexisting phototrophic prokaryotes at the che…

Determinación de la respuesta bronquial a adenosina 5'monofosfato y de la concentración de óxido nítrico en aire exhalado en pacientes con colitis ul…

2009

Las manifestaciones pulmonares de la colitis ulcerosa son una de las manifestaciones extraintestinales menos frecuentes. La afectación pulmonar subclínica es mas frecuente que la enfermedad pulmonar activa. En una revisión publicada en el año 2003, los autores destacan como un 62,5% de los casos registrados presentan afectación pulmonar subclinica (alteraciones en la espirometría, volúmenes pulmonares, difusión pulmonar, permeabilidad pulmonar o hallazgos en el lavado broncoalveolar). La determinación de óxido nítrico en aire exhalado (ENO) y la provocación bronquial con adenosina 5´-monofosfato (AMP) y metacolina han permitido estudiar la inflamación y las alteraciones estructurales bronqu…

Three-dimensional hysterosonography for the study of endometrial tumors: comparison with conventional transvaginal sonography, hysterosalpingography,…

1997

We studied endometrial thickness and homogeneity in 36 patients with postmenopausal bleeding using three-dimensional ultrasound following distention of the uterine cavity with a sterile saline solution (3D-SHSG). Results with 3D-SHSG were compared with findings using transvaginal sonography, transvaginal sonohysterography, transvaginal color Doppler, and hysteroscopy. Sixteen patients (including three on tamoxifen) were undergoing hormone therapy at the time when they were studied. Visualization of the uterine cavity and of endometrial thickness was better with 3D-SHSG than with any of the other ultrasound techniques. The results with 3D-SHSG corresponded to the findings observed with hyste…

Extracellular Vesicles From the Helminth Fasciola hepatica Prevent DSS-Induced Acute Ulcerative Colitis in a T-Lymphocyte Independent Mode

2018

The complexity of the pathogenesis of inflammatory bowel disease (ulcerative colitis and Crohn's disease) has led to the quest of empirically drug therapies, combining immunosuppressant agents, biological therapy and modulators of the microbiota. Helminth parasites have been proposed as an alternative treatment of these diseases based on the hygiene hypothesis, but ethical and medical problems arise. Recent reports have proved the utility of parasite materials, mainly excretory/secretory products as therapeutic agents. The identification of extracellular vesicles on those secreted products opens a new field of investigation, since they exert potent immunomodulating effects. To assess the ef…

N-(2-methyl-indol-1H-5-yl)-1-naphthalenesulfonamide : a novel reversible antimitotic agent inhibiting cancer cell motility

2016

Este es el post-print que se ha publicado de forma definitiva en: https://www.sciencedirect.com/science/article/abs/pii/S0006295216301423 A series of compounds containing the sulfonamide scaffold were synthesized and screened for their in vitro anticancer activity against a representative panel of human cancer cell lines, leading to the identification of N-(2-methyl-1H-indol-5-yl)-1-naphthalenesulfonamide (8e) as a compound showing a remarkable activity across the panel, with IC50 values in the nanomolar-to-low micromolar range. Cell cycle distribution analysis revealed that 8e promoted a severe G2/M arrest, which was followed by cellular senescence as indicated by the detection of senescen…