Search results for "Escape"
showing 10 items of 119 documents
Resistance of Cancer Stem Cells to Cell-Mediated Immune Responses
2015
In the past decades, the hierarchical organization of tumors, governed by Cancer Stem Cells (CSCs), have been reported with regard to several tumor types. Advances in sequencing technologies have demonstrated that diverse genetic CSCs subclones, derived from the branching evolution, compete with each other within the tumor mass, thereby contributing to the functional heterogeneity. It is becoming increasingly clear that epigenetic modifications and microenvironmental influences are important determinants of tumor fitness resulting in disease progression, recurrence and reduced patient survival. Therefore, more effective therapies will require gaining insights into the role of genetic and no…
MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer.
2013
It is now largely admitted that a pro-inflammatory environment may curtail anti-tumor immunity and favor cancer initiation and progression. The discovery that small non-coding regulatory RNAs, namely microRNAs (miRNAs), regulate all aspects of cell proliferation, differentiation, and function has shed a new light on regulatory mechanisms linking inflammation and cancer. Thus, miRNAs such as miR-21, miR-125b, miR-155, miR-196, and miR-210 that are critical for the immune response or hypoxia are often overexpressed in cancers and leukemias. Given the high number of their target transcripts, their deregulation may have a number of deleterious consequences, depending on the cellular context. In…
Grouping facilitates avoidance of parasites by fish
2013
Background. Parasite distribution is often highly heterogeneous, and intensity of infection depends, among other things, on how well hosts can avoid areas with a high concentration of parasites. We studied the role of fish behaviour in avoiding microhabitats with a high infection risk using Oncorhynchus mykiss and cercariae of Diplostomum pseudospathaceum as a model. Spatial distribution of parasites in experimental tanks was highly heterogeneous. We hypothesized that fish in groups are better at recognizing a parasitized area and avoiding it than solitary fish. Methods. Number of fish, either solitary or in groups of 5, was recorded in different compartments of a shuttle tank where fish co…
Manipulation of fish host by eye flukes in relation to cataract formation and parasite infectivity
2005
Trophically transmitted parasites may predispose infected hosts to predation by altering host behaviour, which can be either an adaptation of the parasites to enhance transmission to the next hosts in the life cycle or a nonadaptive side-effect of infection. In an experimental study, we investigated host manipulation by Diplostomum spathaceum (Trematoda), an eye fluke of fish, to evaluate its adaptive value as a parasite strategy to increase transmission efficiency to bird hosts. The parasite induces cataract formation in the lenses of fish eyes, and predisposes fish to predation by reducing their escape response. We examined the effect of developmental stage and the number of parasites on …
“Alimental, querido Watson” – Escape room virtual para la asignatura de Alimentación y Dietética
2021
[EN] "Alimental, querido Watson" is a digital educational escape room created for the subject "Nutrition and Dietetics" of the degree in Medicine at the University of Valencia. The objective of this activity was to maintain the students participation and adherence in the subject in spite of being teached in an on-line asynchronous way during the 2020/2021 academic year. Furthemore, we also wanted to encourage their learning by solving the different enigmas, always related to the contents of the subject. The results from this activity show that, as expected, students had a greater involvement and satisfaction with the activity, as well as a higher academic performance. Therefore, our experie…
Phase dynamics in graphene-based Josephson junctions in the presence of thermal and correlated fluctuations
2014
In this work we study by numerical methods the phase dynamics in ballistic graphene-based short Josephson junctions. The supercurrent through a graphene junction shows a non-sinusoidal phase-dependence, unlike a conventional junction ruled by the well-known d.c. Josephson relation. A superconductor-graphene-superconductor system exhibits superconductive quantum metastable states similar to those present in normal current-biased JJs. We explore the effects of thermal and correlated fluctuations on the escape time from these metastable states, when the system is stimulated by an oscillating bias current. As a first step, the analysis is carried out in the presence of an external Gaussian whit…
The effect of high-In content capping layers on low-density bimodal-sized InAs quantum dots
2013
[EN] The structural and morphological features of bimodal-sized InAs/(In) GaAs quantum dots with density in the low 10(9) cm(-2) range were analyzed with transmission electron microscopy and atomic force microscopy and were related to their optical properties, investigated with photoluminescence and time-resolved photoluminescence. We show that only the family of small quantum dots (QDs) is able to emit narrow photoluminescence peaks characteristic of single-QD spectra; while the behavior of large QDs is attributed to large strain fields that may induce defects affecting their optical properties, decreasing the optical intensity and broadening the homogeneous linewidth. Then, by using a rat…
Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
2013
Abstract The success in lung cancer therapy with programmed death (PD)-1 blockade suggests that immune escape mechanisms contribute to lung tumor pathogenesis. We identified a correlation between EGF receptor (EGFR) pathway activation and a signature of immunosuppression manifested by upregulation of PD-1, PD-L1, CTL antigen-4 (CTLA-4), and multiple tumor-promoting inflammatory cytokines. We observed decreased CTLs and increased markers of T-cell exhaustion in mouse models of EGFR-driven lung cancer. PD-1 antibody blockade improved the survival of mice with EGFR-driven adenocarcinomas by enhancing effector T-cell function and lowering the levels of tumor-promoting cytokines. Expression of m…
Analysis of soliton dynamics and noise induced effects on the superconductive lifetime in long Josephson junctions.
2013
The influence of various noise sources on the transient dynamics of long Josephson junctions (LJJ) is investigated in the presence of an oscillating bias current signal and a noise source with Gaussian or non-Gaussian (i.e. Cauchy-Lorentz or Lévy-Smirnov) probability distributions. These systems are computationally analyzed integrating the perturbed Sine-Gordon equation describing the phase evolution. We found evidence of noise induced effects on trends of the mean escape time (MET) from the superconductive metastable state, varying different system parameters, as the bias frequency, noise intensity and junction length. In particular, we find resonant activation (RA) and noise enhanced stab…
Transient dynamics in driven long Josephson junctions.
2013
The switching time from the superconductive metastable state of a long Josephson junction (LJJ)[1] is computationally analyzed in the framework of the perturbed sine-Gordon equation. The model includes an external bias current term and a stochastic noise source, i.e. a Lévy noise term. The effects of this noise on the mean escape time (MET) from the superconductive state are analyzed. The investigation is performed by considering a wide range of values of system parameters and different noise statistics: Gaussian, Cauchy-Lorentz and Lévy-Smirnov[2]. We found evidence of well known noise induced phenomena on the MET behavior, that is the noise enhanced stability (NES) and resonant activation…