Search results for "Escape"
showing 10 items of 119 documents
Immunophenotype based on inflammatory cells, PD-1/PD-L1 signalling pathway and M2 macrophages predicts survival in gastric cancer
2020
Abstract Background Immune response against cancer has prognostic impact but its role in gastric cancer is poorly known. The aim of the study was to assess the prognostic significance of immune cell score (CD3+, CD8+), tumour immune escape (PD-L1, PD-1) and immune tolerance (Clever-1). Methods After exclusion of Epstein-Barr virus positive (n = 4) and microsatellite instable (n = 6) tumours, the study included 122 patients with GC undergoing D2 gastrectomy. CD3+ and CD8+ based ICS, PD-L1, PD-1 and Clever-1 expressions were evaluated. Differences in survival were examined using Cox regression adjusted for confounders. The primary outcome was 5-year survival. Results The 5-year overall surviv…
Research Directions in the Study of Gaming-Related Escapism: a Commentary to Melodia, Canale, and Griffiths (2020)
2021
AbstractEscapism motivations and related processes (e.g., avoidance, dissociation, relaxation, and emotion dysregulation) have been identified as risk factors for problematic gaming. However, the escapism construct has often been poorly conceptualized and operationalized in assessment instruments. In their systematic review, Melodia et al. (2020) proposed that conceptualizing escapism as an avoidant coping strategy could provide a sound basis for further study of problematic gaming. In this commentary, we critically examine some terminological and conceptual issues in relation to escapism to guide future research.
The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish
2021
SummaryAnimal behavior is strongly context-dependent and behavioral performance is often modulated by internal state. In particular, different social contexts can alter anxiety levels and modulate social behavior. The vertebrate-specific neuropeptide parathyroid hormone 2 (pth2) is directly regulated by the presence or absence of conspecifics in zebrafish. As its cognate receptor, the parathyroid hormone 2 receptor (pth2r), is widely expressed across the brain, we tested fish lacking the functional Pth2 peptide in several anxiety-related and social paradigms. Rodents lacking PTH2 display increased anxiety-related behavior. Here we show that the propensity to react to sudden stimuli with an …
Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
2016
Melanoma treatment has been revolutionized by antibody-based immunotherapies. IFNγ secretion by CD8+ T cells is critical for therapy efficacy having anti-proliferative and pro-apoptotic effects on tumour cells. Our study demonstrates a genetic evolution of IFNγ resistance in different melanoma patient models. Chromosomal alterations and subsequent inactivating mutations in genes of the IFNγ signalling cascade, most often JAK1 or JAK2, protect melanoma cells from anti-tumour IFNγ activity. JAK1/2 mutants further evolve into T-cell-resistant HLA class I-negative lesions with genes involved in antigen presentation silenced and no longer inducible by IFNγ. Allelic JAK1/2 losses predisposing to …
Optical transitions and excitonic recombination in InAs/InP self-assembled quantum wires
2001
InAs self-assembled quantum wire structures have been grown on InP substrates and studied by means of photoluminescence and polarized-light absorption measurements. According to our calculations, the observed optical transitions in each sample are consistent with wires of different heights, namely from 6 to 13 monolayers. The nonradiative mechanism limiting the emission intensity at room temperature is related to thermal escape of carriers out of the wires.
Mean Escape Time in a System with Stochastic Volatility
2007
We study the mean escape time in a market model with stochastic volatility. The process followed by the volatility is the Cox Ingersoll and Ross process which is widely used to model stock price fluctuations. The market model can be considered as a generalization of the Heston model, where the geometric Brownian motion is replaced by a random walk in the presence of a cubic nonlinearity. We investigate the statistical properties of the escape time of the returns, from a given interval, as a function of the three parameters of the model. We find that the noise can have a stabilizing effect on the system, as long as the global noise is not too high with respect to the effective potential barr…
A Phenomenological Operator Description of Dynamics of Crowds: Escape Strategies
2015
Abstract We adopt an operatorial method, based on creation, annihilation and number operators, to describe one or two populations mutually interacting and moving in a two-dimensional region. In particular, we discuss how the two populations, contained in a certain two-dimensional region with a non-trivial topology, react when some alarm occurs. We consider the cases of both low and high densities of the populations, and discuss what is changing as the strength of the interaction increases. We also analyze what happens when the region has either a single exit or two ways out.
First Flight Escape Probability and Uncollided Flux of Nuclear Particles in Convex Bodies with Spherical Symmetry
2016
This paper deals with the evaluation of the first flight escape probability of nuclear particles from convex bodies with spherical symmetry by means of some geometrical arguments and very simple probability considerations. The cases of a full sphere, a one-region spherical shell with an empty central zone, a spherical shell region containing a black central zone, and a full sphere with a sourceless shell have been considered. In all the aforementioned cases, a homogeneous medium and uniform isotropic source have been taken into account. Moreover, a simple and general formula has been derived for the calculation of the uncollided flux that is presupposed to be valid for arbitrary geometries.…
RESONANT ACTIVATION AND NOISE ENHANCED STABILITY IN JOSEPHSON JUNCTIONS
2005
We investigate the interplay of two noise-induced effects on the temporal characteristics of short overdamped Josephson junctions in the presence of a periodic driving. We find that: (i) the mean life time of superconductive state has a minimum as a function of driving frequency, and near the minimum it actually does not depend on the noise intensity (resonant activation phenomenon); (ii) the noise enhanced stability phenomenon increases the switching time from superconductive to the resistive state. As a consequence there is a suitable frequency range of clock pulses, at which the noise has a minimal effect on pulse propagation in RSFQ electronic devices.
Colorectal Cancer Stem Cells: From the Crypt to the Clinic
2014
Since their first discovery, investigations of colorectal cancer stem cells (CSCs) have revealed some unexpected properties, including a high degree of heterogeneity and plasticity. By exploiting a combination of genetic, epigenetic, and microenvironmental factors, colorectal CSCs metastasize, resist chemotherapy, and continually adapt to a changing microenvironment, representing a formidable challenge to cancer eradication. Here, we review the current understanding of colorectal CSCs, including their origin, relationship to stem cells of the intestine, phenotypic characterization, and underlying regulatory mechanisms. We also discuss limitations to current preclinical models of colorectal …