Search results for "Estro."
showing 10 items of 770 documents
La evolución en los tribunales: aplicaciones forenses de las filogenias moleculares
2013
En las dos últimas décadas se ha generalizado el uso de pruebas genéticas en los tribunales, permitiendo la identificación de criminales a partir de restos biológicos, la determinación de paternidades o la identificación de cadáveres. Menos conocidas son las periciales basadas en el uso de filogenias moleculares. En ellas se estudia la ancestralidad común de organismos, normalmente virus o bacterias, para establecer su asociación a una fuente de infección. Desde el caso del dentista de Florida, que infectó con el VIH a varios de sus pacientes, hasta el más próximo del anestesista Juan Maeso, que transmitió el VHC a cerca de 300 pacientes, la teoría evolutiva tiene un papel esencial en estas…
Recent advances in computational design of potent aromatase inhibitors: open-eye on endocrine-resistant breast cancers.
2019
Introduction: The vast majority of breast cancers (BC) are estrogen receptor positive (ER+). The most effective treatments to fight this BC type rely on estrogen deprivation therapy, by inhibiting the aromatase enzyme, which performs estrogen biosynthesis, or on blocking the estrogens signaling path via modulating/degrading the estrogen's specific nuclear receptor (estrogen receptor-?, ER?). While being effective at early disease stage, patients treated with aromatase inhibitors (AIs) may acquire resistance and often relapse after prolonged therapies. Areas covered: In this compendium, after an overview of the historical development of the AIs currently in clinical use, and of the computati…
New findings on the bioactivity of lignans
2002
Abstract This chapter reviews the lignans with biological and pharmacological activity, and includes new natural products and some synthetic or semisynthetic compounds. Lignans are widespread in plants and in many cases are their effective principles. They play an important role as phytoestrogens in preventing menopausial symptoms, osteoporosis, cancer and heart diseases. Lignans possess anticancer and antiviral properties and specifically inhibit certain enzymes and mediators involved in inflammation and immunity processes. They affect the cardiovascular system by different mechanisms including the modification of phosphodiesterase activity and platelet activating factor function. Lignans …
Estrogen up-regulates apolipoprotein E (ApoE) gene expression by increasing ApoE mRNA in the translating pool via the estrogen receptor alpha-mediate…
1998
The antiatherogenic property of estrogens is mediated via at least two mechanisms: first by affecting plasma lipoprotein profiles, and second by affecting the components of the vessel wall. Raising plasma apolipoprotein E (apoE) in mice protects them against diet-induced atherosclerosis (Shimano, H., Yamada, N., Katsuki, M., Gotoda, T., Harada, K., Murase, T., Fukuzawa, C., Takaku, F., and Yazaka, Y. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 1750-1754). It is possible that estrogen may be antiatherogenic at least in part by increasing plasma apoE levels. Therefore, we studied the regulation of apoE by estrogen. A survey of 15 inbred strains of mice showed that some mouse strains responded …
El maestro de obras Felipe Serrano y la arquitectura valenciana de las últimas décadas del siglo XVII y principios del SVIII
2003
El presente trabajo analiza algunos aspectos de la arquitectura valenciana especialmente durante las tres últimas décadas del siglo XVII y primeros años del XVIII, coincidiendo con el período barroco pleno, a través de una familia de alarifes: los Serrano. Algunos de los más destacados maestros de obras de esta familia repiten el mismo nombre de pila durante varias generaciones: Felipe. El artículo estudia además la trayectoria de algunos de los miembros de esta saga de constructores en el seno del Gremio de Albañiles de la ciudad de Valencia, ofreciendo datos y documentos inéditos sobre sus vidas y quehaceres profesionales. (A)
Formación artística en el grado de maestro de primaria de la Universitat de València. Enfoques y propuestas
2014
Este trabajo presenta una propuesta enfocada a mejorar la docencia en el actual grado de maestro de Primaria en lo que a Educación Artística se refiere, según el plan de estudios de la Facultat de Magisteri de la Universitat de València. La implantación del grado es relativamente reciente con lo cual permite plantearse mejoras que conlleven dotar a los futuros maestros de herramientas que optimicen sus conocimientos del área artística. Así, se llevará a cabo una colaboración horizontal basada en la cooperación entre profesores de las diferentes áreas artísticas: Educación Plástica y Música. Por ello, se plantea la puesta en práctica de una metodología innovadora de índole cooperativa, revis…
Rokmūzikas diskurss jauniešu izdevumos "Liesma" un "Padomju Jaunatne" 1988. un 1989. gadā
2017
Bakalaura darba mērķis ir atklāt, kāds ir rokmūzikas diskurss jauniešu izdevumos “Liesma” un “Padomju Jaunatne” 1988. un 1989. gadā, pētot abu izdevumu attiecīgo gadu publikācijas, kurās tiek rakstīts par rokmūziku vai to saistītajām kulturālajām izpausmēm. Bakalaura darba teorētiskajā daļā aplūkotas teorijas par populāro kultūru, subkultūrām un reprezentāciju. Sniegts ieskats perestroikas periodā un ar to saistītajos notikumos, galvenokārt, ietekmē uz kultūru un medijiem, kā arī apskatīta populārās kultūras un rokmūzikas nozīme Padomju Savienībā perestroikas laikā un kopumā. Ar kvantitatīvās kontentanalīzes un kritiskās diskursa analīzes palīdzību iegūtie rezultāti liecina, ka 1988. un 198…
The effects of histamine on the isolated mouse uterus
2000
1. A study is made of the contractile and relaxant effects, and mechanism of action, of histamine on isolated uterus from mice treated with diethylstilboestrol, employing acetylcholine and adrenaline as contractile and relaxant standard agents. 2. Concentration-response curves for histamine agonists were obtained in the absence and presence of selective histaminergic blocking drugs (clemizole, ranitidine and thioperamide) and indomethacin. A number of experiments were carried out in uterus from reserpinised mice. Concentration-response curves for acetylcholine and adrenaline were also obtained in the absence and presence of their selective antagonist (atropine and propranolol). 3. In isolat…
Bis(hydroxyphenyl)methane-bisphenol F-metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes
2011
author cannot archive publisher's version/PDF; International audience; Bisphenol F (BPF) is present in the environment and as a contaminant of food. Humans may, therefore, be exposed to BPF, and an assessment of this risk is required. BPF has been shown to have genotoxic and endocrine-disruptor properties in a human hepatoma cell line (HepG2), which is a model system for studies of xenobiotic toxicity. In this study, we investigated the ability of HepG2 cells to biotransform BPF, because metabolism may affect the observed effects of BPF, and we compared this metabolic capacity with that of human hepatocytes. Cells were incubated for 24 hours with [(3)H]-BPF. The culture medium was then conc…
The mechanisms of thrombotic risk induced by hormone replacement therapy.
2001
Abstract Objective : To review the available information on the action of hormones on the mechanisms involved in thrombotic risk. Results and Conclusions : Thrombosis plays a crucial role in the genesis and progression of both coronary heart disease (CHD) and venous thromboembolic disease (VTED), the two main forms of cardiovascular disease. Two main determinants of the thromboembolic phenotype, hypercoagulable state and altered endothelium, accumulate much of the work performed on the influence of hormones on thrombosis. Information has accumulated mainly for oestrogens, but increasing evidences support a role for progestogens. The sensitivity of each of the three components of the hemosta…