Search results for "Estro."
showing 10 items of 770 documents
Synthesis and PET studies of [11C-cyano]letrozole (Femara®), an aromatase inhibitor drug
2009
Abstract Introduction Aromatase, a member of the cytochrome P 450 family, converts androgens such as androstenedione and testosterone into estrone and estradiol, respectively. Letrozole (1-[bis-(4-cyanophenyl)methyl]-1 H -1,2,4-triazole; Femara) is a high-affinity aromatase inhibitor ( K i =11.5 nM) that has Food and Drug Administration approval for breast cancer treatment. Here we report the synthesis of carbon-11-labeled letrozole and its assessment as a radiotracer for brain aromatase in the baboon. Methods Letrozole and its precursor (4-[(4-bromophenyl)-1 H -1,2,4-triazol-1-ylmethyl]benzonitrile) were prepared in a two-step synthesis from 4-cyanobenzyl bromide and 4-bromobenzyl bromide,…
Quantitative monoclonal antibody determination of estrogen and progesterone receptors in human breast cancer: correlation with the radioligand method.
1994
To assess the possibility of substituting our routine method (dextran-coated charcoal, DCC) of determining estrogen (ER) and progesterone receptors (PR) for an enzyme immunoassay technique (EIA), we compared the two methods for determination of the two types of receptor in breast cancer specimens. In terms of sample positivity or negativity, the two techniques agreed in 76 of the 82 samples analyzed for ER (92.7%; p0.001), and in 65 out of 75 samples assayed for PR (86.6%; p0.001). Quantitative analysis of the data showed a significant correlation between DCC and EIA for both ER (r = 0.84; p0.0001) and PR (r = 0.77; p0.0001). The results suggest the usefulness of EIA in substituting DCC, al…
Droloxifene-Induced Spikes of Tumor Markers Predict Benefit of Therapy
1991
In the clinical monitoring of cancer, tumor marker proteins may reflect the status of the disease. In cases with radio- and chemotherapy, spikes of tumor markers were found shortly after starting the therapy. These spikes were interpreted as a sign of tumor lysis. Recently during therapy of breast cancer with the new antiestrogen droloxifene, spikes of CA 125 and CA 15-3 were also found in about one-third of patients responding to therapy. The peaks of these initial increases were recorded between 14 and 60 days after the onset of treatment, with maximum concentrations up to 1,890% of the initial value. Marker concentrations decreased thereafter, to new baselines at or below the initial val…
HERS study disturbs hormonal replacement therapy
2000
Cardiovascular protection of hormonal replacement therapy was considered a fact. The effects of estrogens on lipid levels and vascular health gave biological support to estrogen cardioprotection. The recently published HERS study showing no protective effects of estrogen and progesterone replacement therapy on the risk of myocardial infarction or coronary deaths is provoking perplexity. These surprising results may have several causes such as the use of progesterone, the associated use of cardioprotective agents or the short observation period. However, the study results scope is rectricted to secondary prevention. These cannot be extrapolated to frequent conditions of postmenopausal women …
Carrera profesional del maestro de obras del rey en el Reino de Valencia en época de los en la época de los Austrias: la sucesión al cargo que ocupó …
2009
El maestro de obras reales en el Reino de Valencia se ocupó de la supervisión de los trabajos en los bienes inmuebles del patrimonio regio, que incluía arquitectura e ingeniería civil, militar e hidráulica. Presentamos el informe enviado por el virrey en 1622 sobre los tres candidatos al cargo: Antonio Picó, Jerónimo Negret y Francisco Arboreda (o Arboleda). Resulta especialmente interesante la información sobre este último, que lo ocupó hasta 1636, pues en la exposición de méritos, por un lado, ofrece información sobre las obras realizadas por sus ancestros, Joan Arboreda, que identificamos con el Joan Navarro que ocupó el mismo cargo en las décadas centrales del siglo XVI, y Jerónimo Arbo…
Differential regulation of apoptosis-associated genes by estrogen receptor alpha in human neuroblastoma cells
2012
Purpose: The neuroendocrinology of female sex hormones is of great interest for a variety of neuropsychiatric disorders. In fact, estrogens and estrogen receptors (ERs) exert neuromodulatory and neuroprotective functions. Here we investigated potential targets of the ER subtype alpha that may mediate neuroprotection and focused on direct modulators and downstream executors of apoptosis. Methods: We employed subclones of human neuroblastoma cells (SK-N-MC) stably transfected with one of the ER subtypes, ERalpha or ERbeta. Differences between the cell lines regarding the mRNA expression levels were examined by qPCR, changes on protein levels were examined by Western Blot and immunocytochemist…
Estrogen-induced cell signalling in a cellular model of Alzheimer's disease.
2003
Alzheimer's disease (AD) is characterised by deposition of a 4 kDa amyloid-beta peptide (Abeta) into senile plaques of the affected brain. Abeta is a proteolytic product of the membrane protein, amyloid precursor protein (APP). An alternative cleavage pathway involves alpha-secretase activity and results in secretion of a 100 kDa non-amyloidogenic APP (sAPPalpha) and therefore a potential reduction in Abeta secretion. We have shown that estrogen induces alpha-cleavage and therefore results in the secretion of sAPPalpha. This secretion is signalled via MAP-kinase and PI-3 kinase signal-transduction pathways. These pathways also have the potential to inhibit the activation of glycogen synthas…
Molecular mechanisms involved in the hormonal prevention of aging in the rat.
2008
Previous data from our group have provided support for the role of GH, melatonin and estrogens in the prevention of aging of several physiological parameters from bone, liver metabolism, vascular activity, the central nervous system (CNS), the immune system and the skin. In the present work data on the molecular mechanisms involved are presented. A total of 140 male and female rats have been submitted to different treatments over 10 weeks, between 22 and 24 months of age. Males have been treated with GH and melatonin. Females were divided in two groups: intact and castrated at 12 months of age. The first group was treated with GH and melatonin and the second with the two latter compounds an…
Resolución supuesto práctico en el procedimiento selectivo para ingreso en el cuerpo de maestros 2018 para la Comunidad Valenciana
2021
En este documento se encuentra la resolución del supuesto práctico que se planteó en la Comunidad Valenciana durante las oposiciones del año 2018 para el cuerpo de maestros de Educación Infantil. Respondiendo al diseño de una propuesta didáctica contextualizada en los lenguajes plástico, musical y corporal. Atendiendo a la organización y espacios de la misma. Teniendo en cuenta que el centro sigue un programa de tutorización entre Educación Infantil y Primaria y una metodología basada en el Aprendizaje Basado en Proyectos. This document contains the resolution of the practical assumption that was raised in the Valencian Community during the 2018 competitive examinations for early Childhood …
Pyrolytic formation of polyaromatic hydrocarbons from steroid hormones
2011
Author's version of an article published in Food Chemisty, 124 (4), 1466-1472. Also available from the publisher: hhtp://dx.doi.org/10.1016/j.foodchem.2010.07.109 Four steroid hormones, namely androsterone, cholesterol, estrone and estradiol, have been pyrolysed at 300, 400 and 500 °C and the pyrolysates from these have been analysed by GC-MS. The results indicate that these formed different products under the pyrolysis and most of them evolved into polycyclic aromatic hydrocarbons during their residence in the pyrolysis chamber at high temperatures. The products from the pyrolysates, at all temperatures, were analysed for similarities and differences using multivariate data analysis. The p…