Search results for "Ethanolamide"

showing 10 items of 26 documents

Altered endocannabinoid-dynamics in craniopharyngioma patients and their association with HPA-axis disturbances.

2021

Objective Patients with craniopharyngioma (CP) frequently suffer from morbid obesity. Endocannabinoids (ECs) are involved in weight gain and rewarding behavior but have not been investigated in this context. Design Cross-sectional single-center study. Methods Eighteen patients with CP and 16 age- and sex-matched controls were included. Differences in endocannabinoids (2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (AEA)) and endocannabinoid-like molecules (oleoyl ethanolamide (OEA), palmitoylethanolamide (PEA), and arachidonic acid (AA) were measured at baseline and following endurance exercise. We further explored ECs-dynamics in relation to markers of HPA-axis activity (ACT…

AdultMalemedicine.medical_specialtyHypothalamo-Hypophyseal SystemHydrocortisonePolyunsaturated AlkamidesEndocrinology Diabetes and MetabolismHypothalamusContext (language use)Oleic AcidsArachidonic AcidsGlycerideschemistry.chemical_compoundCraniopharyngiomaYoung AdultEndocrinologyCopeptinAdrenocorticotropic HormoneEndurance trainingInternal medicinemedicineEthanolamideHumansPituitary NeoplasmsExerciseArachidonic Acidbusiness.industryGlycopeptidesGeneral MedicineMiddle Agedmedicine.diseaseEndocannabinoid systemCraniopharyngiomaEndurance TrainingEndocrinologyCross-Sectional StudieschemistryCase-Control StudiesArachidonic acidFemalemedicine.symptombusinessWeight gainEndocannabinoidsEuropean journal of endocrinology
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Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothal…

2015

Endocannabinoids participate in the control of neurogenesis, neural cell death and gliosis. The pharmacological effect of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which limits the endocannabinoid degradation, was investigated in the present study. Cell proliferation (phospho-H3(+) or BrdU(+) cells) of the main adult neurogenic zones as well as apoptosis (cleaved caspase-3(+)), astroglia (GFAP(+)), and microglia (Iba1(+) cells) were analyzed in the hippocampus, hypothalamus and striatum of rats intraperitoneally treated with URB597 (0.3 mg/kg/day) at one dose/4-days resting or 5 doses (1 dose/day). Repeated URB597 treatment increased the plasma levels of the N-acylethanolamine…

AstrocitosNeurobiologia del desenvolupamentAmidohidrolasasCannabinoid receptorCarbamatos:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::Apoptosis Regulatory Proteins::Caspases [Medical Subject Headings]:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation::Neurogenesis [Medical Subject Headings]medicine.medical_treatment:Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings]Apoptosis:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight [Medical Subject Headings]chemistry.chemical_compound:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Membrane Proteins::Receptors Cell Surface::Receptors G-Protein-Coupled::Receptors Cannabinoid::Receptor Cannabinoid CB1 [Medical Subject Headings]0302 clinical medicine:Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids Acyclic::Carbamates [Medical Subject Headings]Fatty acid amide hydrolaseReceptor cannabinoide CB1:Organisms::Eukaryota::Animals [Medical Subject Headings]FAAHGliosishealth care economics and organizations:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleosides::Deoxyribonucleosides::Deoxyuridine::Bromodeoxyuridine [Medical Subject Headings]:Chemicals and Drugs::Lipids::Glycerides::Triglycerides [Medical Subject Headings]Original Research0303 health sciencesNeurogenesisBenzamidas:Chemicals and Drugs::Polycyclic Compounds::Steroids::Cholestanes::Cholestenes::Cholesterol [Medical Subject Headings]Endocannabinoid systemEtanolaminas3. Good healthEndocannabinoides:Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Fatty Acids Monounsaturated::Oleic Acids [Medical Subject Headings]CannabinoidesMicroglíalipids (amino acids peptides and proteins)medicine.symptomColesterol:Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Terpenes::Cannabinoids [Medical Subject Headings]:Chemicals and Drugs::Lipids::Fatty Acids::Palmitic Acids [Medical Subject Headings]psychological phenomena and processesProliferación celularmedicine.medical_specialtyCerebroNeurogenesiseducationBiologyBromodesoxiuridina:Anatomy::Nervous System::Neuroglia::Microglia [Medical Subject Headings]Triglicéridoslcsh:RC321-571Ácidos oléicosRatas03 medical and health sciencesCellular and Molecular NeuroscienceInternal medicineHipocampomedicineCaspasa 3:Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus [Medical Subject Headings]:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation [Medical Subject Headings]lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry030304 developmental biologyPalmitoylethanolamide:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoids [Medical Subject Headings]:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Amidohydrolases [Medical Subject Headings]Cannabinoids:Anatomy::Cells::Neuroglia::Astrocytes [Medical Subject Headings]Peso corporalEnergy metabolism:Anatomy::Nervous System::Central Nervous System::Brain [Medical Subject Headings]:Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hypothalamus [Medical Subject Headings]URB597:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death [Medical Subject Headings]:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Gliosis [Medical Subject Headings]:Chemicals and Drugs::Organic Chemicals::Amines::Amino Alcohols::Ethanolamines [Medical Subject Headings]Muerte celular:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats [Medical Subject Headings]EndocrinologyURB597chemistryGliosisnervous systemGlucosaCannabinoidEnergy Metabolism:Chemicals and Drugs::Organic Chemicals::Amides::Benzamides [Medical Subject Headings]HipotálamoÁcidos palmíticos030217 neurology & neurosurgeryNeuroscienceFrontiers in Cellular Neuroscience
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Link between Intestinal CD36 Ligand Binding and Satiety Induced by a High Protein Diet in Mice

2012

International audience; CD36 is a ubiquitous membrane glycoprotein that binds long-chain fatty acids. The presence of a functional CD36 is required for the induction of satiety by a lipid load and its role as a lipid receptor driving cellular signal has recently been demonstrated. Our project aimed to further explore the role of intestinal CD36 in the regulation of food intake. Duodenal infusions of vehicle or sulfo-N-succinimidyl-oleate (SSO) was performed prior to acute infusions of saline or Intralipid (IL) in mice. Infusion of minute quantities of IL induced a decrease in food intake (FI) compared to saline. Infusion of SSO had the same effect but no additive inhibitory effect was obser…

CD36 AntigensMaleTime FactorsAnatomy and Physiologymedicine.medical_treatmentCD36[SDV]Life Sciences [q-bio]lcsh:MedicineOleic AcidsLigandsSatiety ResponseBiochemistryJejunumFood-intakeEatingMiceOleoylethanolamidechemistry.chemical_compound0302 clinical medicineIntestinal Mucosalcsh:ScienceReceptorSalineAnimal Management2. Zero hunger0303 health sciencesMultidisciplinaryAgricultureLipidsIntestinesmedicine.anatomical_structureSatiety Response030220 oncology & carcinogenesisChain Fatty-AcidsMedicineProtein BindingResearch ArticleReceptormedicine.medical_specialtySuccinimidesTransportBiologyBody-weightAbsorption03 medical and health sciencesInternal medicinemedicineAnimalsCholesterol UptakeBiologyNutrition030304 developmental biologyEvolutionary Biologylcsh:ROleoylethanolamideGluconeogenesisProteinsSmall intestineDietMice Inbred C57BLEndocrinologyGene Expression RegulationGluconeogenesischemistryImmunologybiology.proteinRatVeterinary Sciencelcsh:QZoology[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
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Anandamide inhibits IL-12p40 production by acting on the promoter repressor element GA-12: Possible involvement of the COX-2 metabolite prostamide E 2

2007

The eCB [endoCB (cannabinoid)] system is being considered as a novel therapeutic target for immune disorders. Cytokines of the IL-12 (interleukin-12) family have essential functions in cell-mediated immunity. In the present study, we have addressed the mechanisms of action of the eCB AEA (anandamide) on the regulation of IL-12p40 in activated microglia/macrophages. We demonstrated that AEA can inhibit the expression of p35, p19 and p40 subunits, which form the biologically-active cytokines IL-12 and IL-23 in microglia stimulated with LPS (lipopolysaccharide)/IFNγ (interferon γ). Additionally, we have provided evidence that AEA reduces the transcriptional activity of the IL-12p40 gene in LPS…

Lipopolysaccharidesmedicine.medical_specialtyPolyunsaturated Alkamidesmedicine.medical_treatmentMolecular Sequence DataRepressorArachidonic AcidsBiologyInterleukin-23BiochemistryDinoprostoneInterferon-gammaMicechemistry.chemical_compoundInternal medicinemedicineAnimalsEthanolamidePromoter Regions GeneticReceptors CannabinoidMolecular BiologyCells CulturedRegulation of gene expressionMice Inbred BALB CInterleukin-12 Subunit p40Cell BiologyAnandamideEndocannabinoid systemCell biologyProtein SubunitsEndocrinologyGene Expression RegulationchemistryCyclooxygenase 2lipids (amino acids peptides and proteins)MicrogliaCannabinoidSignal transductionEndocannabinoidsSignal TransductionProstaglandin E
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A moderate diet restriction during pregnancy alters the levels of endocannabinoids and endocannabinoid-related lipids in the hypothalamus, hippocampu…

2017

Existe para su consulta material suplementario aportado por el editor. Undernutrition during pregnancy has been associated to increased vulnerability to develop metabolic and behavior alterations later in life. The endocannabinoid system might play an important role in these processes. Therefore, we investigated the effects of a moderate maternal calorie-restricted diet on the levels of the endocannabinoid 2-arachidonoyl glycerol (2-AG), arachidonic acid (AA) and the N-acylethanolamines (NAEs) anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) in the brain of newborn rat offspring. We focused on brain structures involved in metabolism, feeding behavior, as well as em…

Male0301 basic medicineLitter (animal)Desnutrición:Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Olfactory Pathways::Olfactory Bulb [Medical Subject Headings]:Organisms::Eukaryota::Animals::Animal Population Groups::Animals Newborn [Medical Subject Headings]Ácido Araquidónicolcsh:MedicineHippocampusBiochemistry:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Anthropometry::Body Weights and Measures::Body Size::Body Weight::Birth Weight [Medical Subject Headings]Oleoylethanolamidechemistry.chemical_compound0302 clinical medicinePregnancyMedicine and Health Sciences:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats Wistar [Medical Subject Headings]MasculinoPeso al nacerlcsh:Science:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings]MultidisciplinaryFemeninoBrainNeurochemistryPlantsLegumesLipidsOlfactory BulbEndocannabinoid systemEndocannabinoidesEncéfaloHypothalamusEmocionesFemalelipids (amino acids peptides and proteins)Restricción calóricaNeurochemicalsAnatomy:Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Malnutrition [Medical Subject Headings]:Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Arachidonic Acids [Medical Subject Headings]Research ArticleBulbo olfatoriomedicine.medical_specialtyEmbarazoAnimales recién nacidos:Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Energy Intake::Caloric Restriction [Medical Subject Headings]OffspringHypothalamus:Check Tags::Male [Medical Subject Headings]Biology03 medical and health sciencesInternal medicineHipocampomedicineAnimals:Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus [Medical Subject Headings]:Chemicals and Drugs::Lipids::Fatty Acids::Endocannabinoids [Medical Subject Headings]Rats WistarCaloric RestrictionNutritionPregnancyPalmitoylethanolamideCognición:Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition [Medical Subject Headings]Ratas wistarlcsh:RMalnutritionOrganismsPeasBiology and Life Sciences:Anatomy::Nervous System::Central Nervous System::Brain [Medical Subject Headings]:Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hypothalamus [Medical Subject Headings]Lipid Metabolismmedicine.diseaseRatsDietOlfactory bulb030104 developmental biologyEndocrinology:Check Tags::Female [Medical Subject Headings]Animals Newbornnervous systemchemistry:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions [Medical Subject Headings]lcsh:QHipotálamo030217 neurology & neurosurgeryEndocannabinoidsNeurosciencePLOS ONE
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Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans

2017

Abstract Background Endocannabinoids are critical for rewarding behaviors such as eating, physical exercise, and social interaction. The role of endocannabinoids in mammalian sexual behavior has been suggested because of the influence of cannabinoid receptor agonists and antagonists on rodent sexual activity. However, the involvement of endocannabinoids in human sexual behavior has not been studied. Aim To investigate plasma endocannabinoid levels before and after masturbation in healthy male and female volunteers. Outcomes Plasma levels of the endocannabinoids 2-arachidonoylglycerol (2-AG), anandamide, the endocannabinoid-like lipids oleoyl ethanolamide and palmitoyl ethanolamide, arachido…

Male0301 basic medicinemedicine.medical_specialtyCannabinoid receptorPolyunsaturated AlkamidesUrologyEndocrinology Diabetes and MetabolismHuman sexual response cycleSexual arousalmedia_common.quotation_subject2-ArachidonoylglycerolOleic AcidsArachidonic AcidsOrgasmGlycerides03 medical and health scienceschemistry.chemical_compound0302 clinical medicineEndocrinologyInternal medicineCannabinoid Receptor ModulatorsmedicineHumansEthanolamideOrgasmmedia_commonCannabinoid Receptor AgonistsAnandamideEndocannabinoid systemMasturbationPsychiatry and Mental health030104 developmental biologyEndocrinologyReproductive MedicinechemistryFemalelipids (amino acids peptides and proteins)Psychologypsychological phenomena and processes030217 neurology & neurosurgeryEndocannabinoidsThe Journal of Sexual Medicine
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Oral Palmitoylethanolamide Treatment Is Associated with Reduced Cutaneous Adverse Effects of Interferon-β1a and Circulating Proinflammatory Cytokines…

2016

Palmitoylethanolamide (PEA) is an endogenous lipid mediator known to reduce pain and inflammation. However, only limited clinical studies have evaluated the effects of PEA in neuroinflammatory and neurodegenerative diseases. Multiple sclerosis (MS) is a chronic autoimmune and inflammatory disease of the central nervous system. Although subcutaneous administration of interferon (IFN)-β1a is approved as first-line therapy for the treatment of relapsing–remitting MS (RR-MS), its commonly reported adverse events (AEs) such as pain, myalgia, and erythema at the injection site, deeply affect the quality of life (QoL) of patients with MS. In this randomized, double-blind, placebo-controlled study,…

Male0301 basic medicinemyalgiaErythemaAnti-Inflammatory AgentsPalmitic AcidAdministration OralPharmacologyGastroenterologychemistry.chemical_compound0302 clinical medicineNeuroinflammationFAAHEthanolaminePharmacology (medical)SkinInterleukin-17food and beveragesAnti-Inflammatory AgentTolerabilityEthanolaminesDisease ProgressionCytokinesOriginal ArticleFemalemedicine.symptomInterferon beta-1aHumanAdultmedicine.medical_specialtyPainPalmitic AcidsProinflammatory cytokineInterferon-gamma03 medical and health sciencesMultiple Sclerosis Relapsing-RemittingDouble-Blind MethodInternal medicinemedicineHumansAdverse effectCytokinePharmacologyPalmitoylethanolamideExpanded Disability Status ScaleTumor Necrosis Factor-alphabusiness.industryMultiple sclerosisN-acylethanolamineOleoylethanolamideAnandamideNAAAmedicine.diseaseAmides030104 developmental biologychemistryNeurology (clinical)business030217 neurology & neurosurgeryNeurotherapeutics
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Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia.

2008

The endocannabinoids anandamide (AEA) and palmitoylethanolamide (PEA) act as endogenous protective factors of the brain, using different pathways of neuroprotection against neuronal damage. Although several in vivo and in vitro studies confirmed the neuroprotective efficacy of endocannabinoids, no experimental settings compare and explore the neuroprotective potential of AEA and PEA in an acute stroke model. In this study, we investigated the neuroprotective potential by infarct measurement after high (30 mg/kg body weight) and low dosage administration (10 mg/kg body weight) of the endocannabinoid PEA in 49 male Wistar rats. In additions we studied infarct volumes of 22 male Wistar rats re…

MaleCannabinoid receptormedicine.medical_treatmentIschemiaPharmacologyNeuroprotectionBrain ischemiachemistry.chemical_compoundCannabinoid Receptor ModulatorsMedicineAnimalsRats WistarMolecular BiologyStrokePalmitoylethanolamidebusiness.industryGeneral NeuroscienceBrainRecovery of Functionmedicine.diseaseEndocannabinoid systemRatsNeuroprotective AgentschemistryIschemic Attack TransientAnesthesialipids (amino acids peptides and proteins)Neurology (clinical)CannabinoidbusinessDevelopmental BiologyEndocannabinoidsBrain research
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Fatty acid amide hydrolase controls mouse intestinal motility in vivo.

2005

Background & Aims: Fatty acid amide hydrolase (FAAH) catalyzes the hydrolysis both of the endocannabinoids (which are known to inhibit intestinal motility) and other bioactive amides (palmitoylethanolamide, oleamide, and oleoylethanolamide), which might affect intestinal motility. The physiologic role of FAAH in the gut is largely unexplored. In the present study, we evaluated the possible role of FAAH in regulating intestinal motility in mice in vivo. Methods: Motility was measured by evaluating the distribution of a fluorescent marker along the small intestine; FAAH messenger RNA (mRNA) levels were analyzed by reverse-transcription polymerase chain reaction (RT-PCR); endocannabinoid level…

MaleOleamideCannabinoid receptormedicine.drug_classMotilityPharmacologyBiologyAmidohydrolaseschemistry.chemical_compoundOleoylethanolamideMiceFatty acid amide hydrolaseIntestine SmallmedicineAnimalsIntestine LargeRNA MessengerGastrointestinal TransitPalmitoylethanolamideMice Inbred ICRHepatologyReverse Transcriptase Polymerase Chain ReactionGastroenterologyReceptor antagonistEndocannabinoid systemKineticsnervous systemBiochemistrychemistrylipids (amino acids peptides and proteins)Gastrointestinal Motilitypsychological phenomena and processesGastroenterology
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Serotonin, the Prefrontal Cortex, and the Antidepressant-Like Effect of Cannabinoids

2007

Preclinical and clinical studies show that cannabis modulates mood and possesses antidepressant-like properties, mediated by the agonistic activity of cannabinoids on central CB1 receptors (CB1Rs). The action of CB1R agonists on the serotonin (5-HT) system, the major transmitter system involved in mood control and implicated in the mechanism of action of antidepressants, remains however poorly understood. In this study, we demonstrated that, at low doses, the CB1R agonist WIN55,212-2 [R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate] exerts potent antidepressant-like properties in the rat forced-swim test (FST). This effect …

MaleSerotoninJournal ClubMorpholinesmedicine.medical_treatmentPrefrontal CortexNaphthalenesPharmacologyEuphoriantAntidepressant likeRats Sprague-Dawleychemistry.chemical_compoundReceptor Cannabinoid CB1mental disordersAnimalsEthanolamideMedicineReceptorPrefrontal cortexNeuronsCannabinoidsDepressionbusiness.industryorganic chemicalsGeneral NeuroscienceAnandamideAntidepressive AgentsBenzoxazinesRatschemistryCannabinoidSerotoninbusinessNeuroscienceThe Journal of Neuroscience
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