Search results for "Ethion"
showing 10 items of 190 documents
Adaptive antioxidant methionine accumulation in respiratory chain complexes explains the use of a deviant genetic code in mitochondria
2008
Humans and most other animals use 2 different genetic codes to translate their hereditary information: the standard code for nuclear-encoded proteins and a modern variant of this code in mitochondria. Despite the pivotal role of the genetic code for cell biology, the functional significance of the deviant mitochondrial code has remained enigmatic since its first description in 1979. Here, we show that profound and functionally beneficial alterations on the encoded protein level were causative for the AUA codon reassignment from isoleucine to methionine observed in most mitochondrial lineages. We demonstrate that this codon reassignment leads to a massive accumulation of the easily oxidized …
Catalysis in glycine N-methyltransferase: testing the electrostatic stabilization and compression hypothesis.
2006
Glycine N-methyltransferase (GNMT) is an S-adenosyl-l-methionine dependent enzyme that catalyzes glycine transformation to sarcosine. Here, we present a hybrid quantum mechanics/molecular mechanics (QM/MM) computational study of the reaction compared to the counterpart process in water. The process takes place through an SN2 mechanism in both media with a transition state in which the transferring methyl group is placed in between the donor (SAM) and the acceptor (the amine group of glycine). Comparative analysis of structural, electrostatic, and electronic characteristics of the in-solution and enzymatic transition states allows us to get a deeper insight into the origins of the enzyme's c…
Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling.
2010
This work identifies the combination of enzymatic transfer and click labeling as an efficient method for the site-specific tagging of RNA molecules for biophysical studies. A double-activated analog of the ubiquitous co-substrate S-adenosyl-l-methionine was employed to enzymatically transfer a five carbon chain containing a terminal alkynyl moiety onto RNA. The tRNA:methyltransferase Trm1 transferred the extended alkynyl moiety to its natural target, the N2 of guanosine 26 in tRNA(Phe). LC/MS and LC/MS/MS techniques were used to detect and characterize the modified nucleoside as well as its cycloaddition product with a fluorescent azide. The latter resulted from a labeling reaction via Cu(I…
Homocysteine and S-adenosylated metabolites in cardiovascular disease
2010
A major unanswered question is whether direct cellular toxicity of homocysteine (Hcy) is causally involved in cardiovascular disease (CVD) in humans or whether homocysteinemia is simply a passive and indirect indicator of a more complex mechanism. Alternatively or additionally, the association between Hcy and CVD may result from its metabolic precursor S-adenosyl-Hcy (SAH), or from the altered ratio of S-adenosylmethionine SAM/SAH. This competition is based on the known effects of these adenosylated metabolites on cellular methylation, disturbances of which may lead to endothelial dysfunction and/ or CVD. Thus, it is of great significance to know how these adenosylated metabolites (SAM, SAH…
Effect of metabolic promoters on yeld and fruit quality of 'Sanfilippara' and 'Trabia' loquat.
2014
CCDC 1485223: Experimental Crystal Structure Determination
2017
Related Article: Cameron M. E. Graham, Taylor E. Pritchard, Paul D. Boyle, Juuso Valjus, Heikki M. Tuononen, Paul J. Ragogna|2017|Angew.Chem.,Int.Ed.|56|6236|doi:10.1002/anie.201611196
CCDC 143150: Experimental Crystal Structure Determination
2001
Related Article: M.A.Girasolo, T.Pizzino, C.Mansueto, G.Valle, G.C.Stocco|2000|Appl.Organomet.Chem.|14|197|doi:10.1002/(SICI)1099-0739(200004)14:4<197::AID-AOC976>3.0.CO;2-H
CCDC 757363: Experimental Crystal Structure Determination
2010
Related Article: V.Noponen, Nonappa, M.Lahtinen, A.Valkonen, H.Salo, E.Kolehmainen, E.Sievanen|2010|Soft Matter|6|3789|doi:10.1039/b925795k
CCDC 757362: Experimental Crystal Structure Determination
2010
Related Article: V.Noponen, Nonappa, M.Lahtinen, A.Valkonen, H.Salo, E.Kolehmainen, E.Sievanen|2010|Soft Matter|6|3789|doi:10.1039/b925795k
CCDC 817951: Experimental Crystal Structure Determination
2012
Related Article: J.Konu, T.Chivers, H.M.Tuononen|2011|Chem.-Eur.J.|17|11844|doi:10.1002/chem.201100891