Search results for "Ethology"
showing 10 items of 162 documents
Metformin Restores AMPK Alpha-Mediated Autophagy and Prevents Carfilzomib-Induced Cardiotoxicity In Vivo
2018
Abstract Introduction: Carfilzomib (Cfz) significantly prolongs progression-free survival in relapsed or refractory multiple myeloma patients, as highlighted in the ENDEAVOR trial. However, Cfz has high incidences of cardiotoxicity and heart failure, leading to treatment cessation. Thus, there is an imperative need for preventive therapies. The study aimed to i) establish an in vivo Cfz cardiotoxicity protocol, ii) investigate the molecular mechanism, identify molecular targets and iii) based on initial results, investigate the potential protective effect and mechanism of Metformin (Met). Methods: Male, C57BL/6 mice, were randomized in groups as following: Acute protocol (6 days): Control (…
Die „Gewichtsphobie” - Ein Diskussionsbeitrag zum Problem der „atypischen” oder „nicht näher bezeichneten”Eß- und Gewichtsstörungen -
2000
A number of authors have stated that the problem of classifying patients whose diagnosis does not meet all the criteria of anorexia and bulimia nervosa has not been satisfactorily solved. The question has been asked if it is justified to regard characteristics like "weight phobia" or body image disturbance as valid diagnostic criteria. In the present study the differences observed in three groups of patients with eating and weight disorders (anorexia: n = 42; bulimia: n = 29; atypical group without "weight phobia": n = 14) were compared using the Giessen-Test. The atypical group was shown to be significantly more "tractable" on scale 2 than the main groups, which achieved a higher score on …
Impairment of PGC-1 Alpha Up-Regulation Enhances Nitrosative Stress in the Liver during Acute Pancreatitis in Obese Mice
2020
Acute pancreatitis is an inflammatory process of the pancreatic tissue that often leads to distant organ dysfunction. Although liver injury is uncommon in acute pancreatitis, obesity is a risk factor for the development of hepatic complications. The aim of this work was to evaluate the role of PGC-1&alpha
Knowledge of alpha-1 deficiency and primary ciliary dyskinesia by medical students and health professionals
2016
Background: Under-diagnosis and delayed diagnosis are common features in rare diseases, which have negative effects on the patients9 prognosis. A possible explanation could be lack of awareness and education of the health professionals involved in the managements of these patients. Alpha-1-antitrypsin deficiency (AATD) and primary ciliary dyskinesia (DCP) are under-diagnosed rare diseases showing a median diagnosis delay of five to ten years. Methods: A survey was undertaken in paediatricians (general, paediatric pulmonologists and paediatric gastroenterologist) and medical school students to assess their knowledge on AATD and PCD. Results: A total of 624 surveys on AATD and 457 on PCD were…
Implications of alpha- and beta-secretase expression and function in Alzheimer's disease
2020
Abstract There has been intense debate in the field about the extent to which processing of the amyloid precursor protein contributes to pathogenesis of Alzheimer's disease. Early publications succeeding in the identification of the main component of senile plaques—the amyloid-beta (A-beta) peptide—strictly argued for a constitutive contribution of A-beta to disease initiation and progression. This led to development of the amyloid hypothesis, which in recent years was attacked for the lack of success of clinical studies based on the respective assumption. There is evidence that the hypothesis must be revisited, but accumulation of A-beta along with aging might still be the best explanation…
Fine structure in the α decay of high-spin isomers in Lu155 and Hf156
2018
Fine structure in the a decay of high-spin isomers in Lu-155( 25/2(-)) and Hf-156(8(+))has been studied for the first time using alpha gamma- coincidence analysis. Three new a decays from Lu-155(25 ...
Alpha decay of the new isotopes207, 208Ac
1994
Two new neutron-deficient isotopes207,208Ac have been produced in fusion reactions with 5.2–5.6 MeV/nucleon40Ar ions on175Lu and identified on the basis of genetic correlations. The fusion evaporation products were separated on-line using a gas-filled magnetic recoil separator. The alpha energy and half-life of208Ac were determined to be (7572±15) keV and (95 −16 +24 ) ms, respectively. A new alpha line with a half-life of (25 −5 +9 ) ms and an energy of (7758±20) keV is assigned to the decay of an isomeric state in208Ac. Another new activity with a half-life of (22 −9 +40 ) ms and an alpha energy of (7712±25) keV is assigned to207Ac.
High-statistics measurement of the β-delayed α spectrum of 20Na
2013
A measurement of the 20Na β-delayed alpha spectrum with a high-granularity setup has allowed the decay scheme to be revised on several points. Three new transitions of low intensity are found at low α -particle energy. An R-matrix fit of the complete spectrum gives an improved description of the decay and indicates feeding to the broad 2+ α-cluster state close to 9MeV. c Societa Italiana di Fisica / Springer-Verlag 2013
Measurement of the decay rate and form factor parameter in the decay KL→e+e−γ
1999
Abstract The decay rate of the neutral K meson KL→e+e−γ has been measured with the NA48 detector at the CERN SPS. A total of 6864 events has been observed with an estimated background of 10 events. The branching ratio is Γ(KL→e+e−γ)/Γ(KL→all) = (1.06±0.02stat±0.02sys±0.04calc)×10−5. The parameter α K ∗ describing the relative strength of the two contributing amplitudes to this decay through intermediate pseudoscalar or vector mesons was measured to be α K ∗ =−0.36±0.06stat±0.02sys.
Intrasexual competition at work: Sex differences in the jealousy-evoking effect of rival characteristics in work settings
2010
Sex differences in jealousy-evoking rival characteristics in the relationship with a supervisor at work were examined in a community sample of 188 individuals from Argentina. Among men, the rivals’ social dominance and communal attributes evoked the most jealousy, followed by physical dominance. Among women, the rival’s communal attributes evoked the most jealousy, followed by social dominance and physical attractiveness. For men physical dominance of the rival and for women physical attractiveness of the rival evoked relatively more jealousy, especially among those high in intrasexual competition and confronted with a same-sex supervisor. When confronted with an opposite-sex supervisor, s…