Search results for "Ethylamphetamine"

showing 4 items of 4 documents

Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human

2004

Abstract 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive designer drug of abuse that is sold under the street names “Venus”, “Bromo”, “Erox”, “XTC” or “Nexus”. Concern has been raised because only little is known about its toxicity and metabolism in humans. In the present study we incubated 2C-B with human, monkey, dog, rabbit, rat and mouse hepatocytes to identify the metabolites formed and to determine possible toxic effects as evidenced by an ATP assay. Our data allow construction of the main metabolic pathways of 2C-B. Oxidative deamination results in the 2-(4-bromo-2,5-dimethoxyphenyl)-ethanol (BDMPE) and 4-bromo-2,5-dimethoxyphenylacetic acid (BDMPAA) metabolites. Additio…

MaleMetaboliteDeaminationMice Inbred StrainsBiologyToxicologyGas Chromatography-Mass SpectrometryRats Sprague-DawleyMicechemistry.chemical_compoundAdenosine TriphosphateDogsSpecies SpecificitymedicineAnimalsHumansCells CulturedDemethylationDose-Response Relationship DrugMolecular Structure25-Dimethoxy-4-MethylamphetamineIllicit DrugsOxidative deaminationMetabolismMiddle AgedRatsMacaca fascicularisMetabolic pathwaymedicine.anatomical_structurechemistryBiochemistryDeaminationHepatocyteHepatocytesRabbitsOxidation-ReductionDrug metabolismToxicology
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Occurrence of illicit drugs in two wastewater treatment plants in the South of Italy

2017

In this study the occurrence and the behavior of illicit drugs and their metabolites have been investigated for two wastewater treatment plants (WWTPs) (namely, WWTP-1 and WWTP-2) located in Sicily (island of Italy). Samples were analyzed for methamphetamine, cocaine (COC), 3,4-methylenedioxymethamphetamine (MDMA), methadone (METH), 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), 3,4-methylenedioxy amphetamine (MDA); 3,4-methylenedioxy ethylamphetamine (MDEA), 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH) and Benzoylecgonine (BEG). The BEG, COC, MOR and THC-COOH were found at the highest concentration in both WWTPs. The Wastewater-based epidemiology calculation for BEG, COC…

PyrrolidinesHealth Toxicology and Mutagenesis0208 environmental biotechnology02 engineering and technologyWastewater010501 environmental sciencesSettore MED/42 - Igiene Generale E ApplicataWaste Disposal Fluid01 natural sciencesMethamphetamineIllicit drugchemistry.chemical_compoundCocaineSettore BIO/10 - BiochimicaCannabidiolWater treatmentDronabinolSicilyDrug behavioreducation.field_of_studybiologyTraditional medicineChemistry (all)MDMAGeneral MedicineMethamphetaminePollutionContaminants of emerging concernSubstance Abuse DetectionDrug CombinationsBenzoylecgoninemedicine.drugEnvironmental EngineeringPopulationmedicineHumansEnvironmental Chemistryeducation0105 earth and related environmental sciencesSettore ICAR/03 - Ingegneria Sanitaria-AmbientaleIllicit Drugsbusiness.industryAmphetaminesCodeinePublic Health Environmental and Occupational HealthGeneral Chemistrybiology.organism_classificationEthylamphetamine020801 environmental engineeringAmphetaminechemistryCannabisbusinessWater Pollutants ChemicalMethadoneChemosphere
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MDMA Administration and Heat Shock Proteins Response: Foreseeing a Molecular Link

2010

Molecular and cellular mechanisms of MDMA-induced toxicity have been extensively studied in a number of experimental models. Nevertheless, only few studies investigated the involvement of HSPs ("molecular chaperones") in MDMA organs toxicity. In the present minireview we highlight this subject analysing the results of these studies conducted especially on brain tissue. Despite of it seems obvious that HSPs overexpression is a protective reaction against MDMA treatment, the molecular mechanisms for exerting their action are far to be undiscovered. At the same time, we need of comprehensive studies concerning the whole range of Hsps/chaperones expressions in all organs after acute and chronic…

N-Methyl-34-methylenedioxyamphetamineModels NeurologicalBrainPharmaceutical ScienceMDMABrain tissuePharmacologyBiologyHeat shock proteinmental disordersToxicityHallucinogensmedicineAnimalsHumans34-Methylenedioxy-N-methylamphetamine brain toxicity Hsp27 Hsp32 Hsp60 Hsp70.Heat-Shock ProteinsHeat-Shock Responsepsychological phenomena and processesBiotechnologymedicine.drugCurrent Pharmaceutical Biotechnology
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2014

Abstract The enantiomeric and diastereomeric profiling of chiral pharmaceuticals (ephedrine, norephedrine, atenolol and venlafaxine) and illicit drugs (amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy- N -methylamphetamine (MDMA) and 3,4-methylenedioxy- N -ethylamphetamine (MDEA)) was undertaken over a period of fourteen consecutive days in three wastewater treatment plants (WWTPs) in the city of Valencia, Spain. Degradation efficiency of WWTPs was found to be compound and enantiomer dependent. Selective enantiomer enrichment was observed for several target analytes. Amphetamine and MDMA were enriched with R (−)-enantiomers. 1 S ,2 S (+)-pseudoephedrine …

Environmental EngineeringChromatographyChemistryDiastereomerMDMAAtenololPollutionEthylamphetaminemedicineEnvironmental ChemistryStereoselectivityEphedrineEnantiomerAmphetamineWaste Management and Disposalmedicine.drugScience of The Total Environment
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