Search results for "ExAC"

Radiometric correction effects in Landsat multi‐date/multi‐sensor change detection studies

2006

Radiometric corrections serve to remove the effects that alter the spectral characteristics of land features, except for actual changes in ground target, becoming mandatory in multi‐sensor, multi‐date studies. In this paper, we evaluate the effects of two types of radiometric correction methods (absolute and relative) for the determination of land cover changes, using Landsat TM and Landsat ETM+ images. In addition, we present an improvement made to the relative correction method addressed. Absolute correction includes a cross‐calibration between TM and ETM+ images, and the application of an atmospheric correction protocol. Relative correction normalizes the images using pseudo‐invariant fe…

Breast cancer subtypes can be determinant in the decision making process to avoid surgical axillary staging: A retrospective cohort study.

2015

Abstract Introduction The need for performing axillary lymph-node dissection in early breast cancer when the sentinel lymph node (SLN) is positive has been questioned in recent years. The purpose of this study was to identify a low-risk subgroup of early breast cancer patients in whom surgical axillary staging could be avoided, and to assess the probability of having a positive lymph-node (LN). Methods We evaluated the cohort of 612 consecutive women affected by early breast cancer. We considered age, tumor size, histological grade, vascular invasion, lymphatic invasion and cancer subtype (Luminal A, Luminal B HER-2+, Luminal B HER-2−, HER-2+, and Triple Negative) as variables for univariat…

Identification of a genetic signature enriching for response to ibrutinib in relapsed/refractory follicular lymphoma in the DAWN phase 2 trial.

2021

Abstract Background The single‐arm DAWN trial (NCT01779791) of ibrutinib monotherapy in patients with relapsed/refractory follicular lymphoma (FL) showed an overall response rate (ORR) of 20.9% and a median response duration of 19.4 months. This biomarker analysis of the DAWN dataset sought to determine genetic classifiers for prediction of response to ibrutinib treatment. Methods Whole exome sequencing was performed on baseline tumor samples. Potential germline variants were excluded; a custom set of 1216 cancer‐related genes was examined. Responder‐ versus nonresponder‐associated variants were identified using Fisher's exact test. Classifiers with increasing numbers of genes were created …

2015

Background Immunotherapy can become a crucial therapeutic option to improve prognosis for lung cancer patients. First clinical trials with therapies targeting the programmed cell death receptor PD-1 and its ligand PD-L1 have shown promising results in several solid tumors. However, in lung cancer the diagnostic, prognostic and predictive value of these immunologic factors remains unclear. Method The impact of both factors was evaluated in a study collective of 321 clinically well-annotated patients with non-small lung cancer (NSCLC) using immunohistochemistry. Results PD-1 expression by tumor infiltrating lymphocytes (TILs) was found in 22%, whereas tumor cell associated PD-L1 expression wa…

The prognostic impact of PD1 and PDL1 expression in non-small cell lung cancer

2015

Introduction: To improve the prognosis of lung cancer patients, immunotherapy is expected to become a powerful therapeutic option. Several clinical studies demonstrate a positive prognostic effect of a targeted therapy against the programmed cell death receptor PD1 and its ligand PDL1 in solid tumors. For non-small lung cancer (NSCLC) however, the diagnostic, prognostic and predictive impact of these factors needs to be clarified. Materials and Methods: Immunohistochemistry was performed to evaluate the expression profile of PD1 and PDL1 in 398 NSCLC patients (median age: 66 years, 78% male sex, 45% squamous cell carcinoma (SCC) histology). Statistical analysis included Fisher9s Exact test,…

Dissipative soliton resonance in a full polarization-maintaining fiber ring laser at different values of dispersion

2016

We investigated the dissipative solitons resonance in an ytterbium-doped fiber ring laser in which all the elements are polarization maintaining (PM). A semiconductor saturable absorber mirror was used as a mode-locker. The cavity included a normal dispersion single-mode fiber (SMF) and an anomalous dispersion photonic crystal fiber. The change of the length of the PM SMF allows the variation of the net-normal dispersion of the cavity in the range from 0.022 ps2 to 0.262 ps2. As the absolute value of the net-normal dispersion increases from 0.022 ps2 to 0.21 ps2, a square-shaped single pulse transformed to a single right-angle trapezoid-shaped pulse, and, at the dispersion of 0.262 ps2, to …

Instantaneous frequency measurement by in-fiber 0.5th order fractional differentiation

2016

We experimentally demonstrate the possibility to retrieve the instantaneous frequency profile of a given temporal light pulse by in-fiber fractional order differentiation of 0.5th-order. The signal's temporal instantaneous frequency profile is obtained by simple dividing two temporal intensity profiles, namely the intensities of the input and output pulses of a spectrally-shifted fractional order differentiation. The results are supported by the experimental measurement of the instantaneous frequency profile of a mode-locked laser. Fil: Poveda-Wong, L.. Universidad de Valencia; España Fil: Carrascosa, A.. Universidad de Valencia; España Fil: Cuadrado Laborde, Christian Ariel. Consejo Nacion…

Experimental demonstration of fractional order differentiation using a long-period grating-based in-fiber modal interferometer

2016

In this work we demonstrate both, experimentally and theoretically, that a long-period grating-based in-fiber modal interferometer can perform an all-optical arbitrary-order fractional differentiation. Experimentally, we fractionally differentiated to the 0.5th order a secant hyperbolic-like pulse of 23 ps time width provided by a 1039.5 nm emission wavelength modelocked fiber laser, with a chirp parameter of −30. An analytical expression relating the fractional order of differentiation n with the characteristics of the modal interferometer was also derived, with the purpose to simplify the design procedure. The proposal was corroborated also numerically. This device may find applications i…

The Peregrine soliton in nonlinear fibre optics

2010

International audience; The Peregrine soliton is a localized nonlinear structure predicted to exist over 25 years ago, but not so far experimentally observed in any physical system. It is of fundamental significance because it is localized in both time and space, and because it defines the limit of a wide class of solutions to the nonlinear Schrödinger equation (NLSE). Here, we use an analytic description of NLSE breather propagation to implement experiments in optical fibre generating femtosecond pulses with strong temporal and spatial localization, and near-ideal temporal Peregrine soliton characteristics. In showing that Peregrine soliton characteristics appear with initial conditions th…

Acousto-optic interaction in biconical tapered fibers: shaping of the stopbands

2016

The effect of a gradual reduction of the fiber diameter on the acousto-optic (AO) interaction is reported. The experimental and theoretical study of the intermodal coupling induced by a flexural acoustic wave in a biconical tapered fiber shows that it is possible to shape the transmission spectrum, for example, substantially broadening the bandwidth of the resonant couplings. The geometry of the taper transitions can be regarded as an extra degree of freedom to design the AO devices. Optical bandwidths above 45 nm are reported in a tapered fiber with a gradual reduction of the fiber down to 70 μm diameter. The effect of including long taper transition is also reported in a double-tapered st…