Search results for "ExPEC"

Nuevas herramientas y nuevas ideas para los responsables de recursos humanos. Validez estructural y predictiva del cuestionario de satisfacción ponde…

2013

One of the fundamental tasks for an Human Resource Management (HRM) practitioner consists in designing a reward system that can be broadly understood and can influence the attitudes and, subsequently, the behavior of individuals to permit achievement of organizational objectives. To do so, appropriate tools are necessary to allow key actions to be identified in terms of motivating employees; thereby, avoiding opportunistic costs derived from allocating resources needed to close the gap in employee satisfaction, with regard to non-priority factors for workers in satisfying their own personal needs. This article, thus, presents a dual assessment scale consisting of 44 items, categorized into …

Delayed Motherhood Decreases Life Expectancy of Mouse Offspring1

2005

Abstract This study analyzes the long-term effects of delayed motherhood on reproductive fitness and life expectancy of offspring in the mouse. Hybrid (C57BL/6JIco × CBA/JIco) first-generation (F1) females, either at the age of 10 or 51 wk, were individually housed with a randomly selected 12- to 14-wk-old hybrid male following a breeding pen system until females reached the end of their reproductive life. Reproductive fitness of second-generation (F2) females was tested from the age of 25 wk until the end of their reproductive life. In F2 males, the testing period ranged from the age of 52 wk until their natural death. Delayed motherhood of hybrid F1 female mice was associated with a decre…

Statistical properties of the site-frequency spectrum associated with lambda-coalescents.

2013

Abstract Statistical properties of the site-frequency spectrum associated with Λ-coalescents are our objects of study. In particular, we derive recursions for the expected value, variance, and covariance of the spectrum, extending earlier results of Fu (1995) for the classical Kingman coalescent. Estimating coalescent parameters introduced by certain Λ-coalescents for data sets too large for full-likelihood methods is our focus. The recursions for the expected values we obtain can be used to find the parameter values that give the best fit to the observed frequency spectrum. The expected values are also used to approximate the probability a (derived) mutation arises on a branch subtending a…

Climate Change, Uncertainty and Ethical Superstorms

2021

I argue that one of the most urgent tasks of geoethics is how to deal with climate change in a just and equitable way. At worst, our current path could lead to multi-metre sea-level rise, increases in storms and climate extremes, causing devastating social disruption and economic consequences. I present some alternatives on how to handle this alarming prospect, arguing that we cannot condense our decision-making on climate change into numerical calculations, but should instead make ethical judgements. The commonly used expected utility maximation can be considered a gamble on future generations’ expense for the benefit of the current ones. Thus, from a Rawlsian perspective, we will instead …

Oxidative Stress and Respiratory System: Pharmacological and Clinical Reappraisal of N-Acetylcysteine

2014

Abstract The large surface area for gas exchange makes the respiratory system particularly susceptible to oxidative stress-mediated injury. Both endogenous and exogenous pro-oxidants (e.g. cigarette smoke) trigger activation of leukocytes and host defenses. These mechanisms interact in a ìmultilevel cycleî responsible for the control of the oxidant/antioxidant homeostasis. Several studies have demonstrated the presence of increased oxidative stress and decreased antioxidants (e.g. reduced glutathione [GSH]) in subjects with chronic obstructive pulmonary disease (COPD), but the contribution of oxidative stress to the pathophysiology of COPD is generally only minimally discussed. The aim of t…

Nanocomplexes for gene therapy of respiratory diseases: Targeting and overcoming the mucus barrier

2015

Gene therapy, i.e. the delivery and expression of therapeutic genes, holds great promise for congenital and acquired respiratory diseases. Non-viral vectors are less toxic and immunogenic than viral vectors, although they are characterized by lower efficiency. However, they have to overcome many barriers, including inflammatory and immune mediators and cells. The respiratory and airway epithelial cells, the main target of these vectors, are coated with a layer of mucus, which hampers the effective reaching of gene therapy vectors carrying either plasmid DNA or small interfering RNA. This barrier is thicker in many lung diseases, such as cystic fibrosis. This review summarizes the most impor…

Expecting the unexpected: Quantifying the persistence of unexpected hypersurfaces

2021

If $X \subset \mathbb P^n$ is a reduced subscheme, we say that $X$ admits an unexpected hypersurface of degree $t$ for multiplicity $m$ if the imposition of having multiplicity $m$ at a general point $P$ fails to impose the expected number of conditions on the linear system of hypersurfaces of degree $t$ containing $X$. Conditions which either guarantee the occurrence of unexpected hypersurfaces, or which ensure that they cannot occur, are not well understand. We introduce new methods for studying unexpectedness, such as the use of generic initial ideals and partial elimination ideals to clarify when it can and when it cannot occur. We also exhibit algebraic and geometric properties of $X$ …

Gaussian surface measures and the radon transform on separable banach spaces

1980

Vector Mesons and Dence Skyrmion Matter

2004

In our continuing effort to understand hadronic matter at high density, we have developed a unified field theoretic formalism for dense skyrmion matter using a single Lagrangian to describe simultaneously both matter and meson fluctuations and studied in-medium properties of hadrons. Dropping the quartic Skyrme term, we incorporate into our previous Lagrangian the vector mesons rho and omega in a form which is consistent with the symmetries of QCD. The results that we have obtained, reported here, expose a hitherto unsuspected puzzle associated with the role the omega meson plays at short distance. Since the omega meson couples to baryon density, it leads to a pseudo-gap scenario for the ch…

Deep inelastic scattering on the quark-gluon plasma

2020

We provide an interpretation of the structure functions of a thermal medium such as the quark-gluon plasma in terms of the scattering of an incoming electron on the medium via the exchange of a spacelike photon. We then focus on the deep-inelastic scattering (DIS) regime, and formulate the corresponding moment sum rules obeyed by the structure functions. Accordingly, these moments are given by the thermal expectation value of twist-two operators, which is computable from first principles in lattice QCD for the first few moments. We also show how lattice QCD calculations can be used to probe how large the photon virtuality needs to be in order for the Bjorken scaling of structure functions t…