Search results for "Exam"
showing 10 items of 1241 documents
Poly(ADP-ribosyl)ation accelerates DNA repair in a pathway dependent on Cockayne syndrome B protein
2003
Activation of poly(ADP-ribose)polymerases 1 and 2 (PARP-1 and PARP-2) is one of the earliest responses of mammalian cells to DNA damage by numerous genotoxic agents. We have analysed the influence of PARP inhibition, either achieved by over-expression of the DNA binding domain of PARP-1 or by treatment with 3,4-dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone, on the repair of single-strand breaks (SSB), pyrimidine dimers and oxidative base modifications sensitive to Fpg protein (mostly 8-hydroxyguanine) in mammalian cells at very low, non-cytotoxic levels of DNA damage. The data show that the repair rates of all three types of DNA damage are significantly lower in PARP-inhibited c…
Responsability in management of the early stages in clinical evaluation of oral-facial traumatic events
2019
Obiettivi Scopo del presente lavoro è esaminare gli eventi traumatici oro-facciali e i loro effetti e individuare linee e schemi comportamentali e un linguaggio clinico e medico-legale appropriato che aiutino a identificare con immediatezza l’evento traumatico e i suoi postumi, e una corretta gestione dello stesso, in modo consono alle esigenze assicurative e/o giudiziarie, oltre che strettamente cliniche. Si vuole, inoltre, sottolineare l’importanza clinica e medico-legale della prima visita. Materiali e metodi I diversi aspetti dell’argomento sono esaminati sia da un punto di vista clinico che medico legale. Attraverso l’analisi delle diverse tipologie di trauma e degli schemi procedurali…
Viabilidad de la informatización del examen lengua extranjera de las Pruebas de Acceso a la Universidad
2016
[ES] Tras el anuncio por parte del Gobierno de la inclusión de una sección oral en el examen de lengua extranjera de la Prueba de Acceso a la Universidad, que estaba prevista para 2012, diferentes posibilidades en cuanto a la informatización de dicha sección se analizaron en un esfuerzo por encontrar una propuesta viable para la evaluación de las destrezas orales y un estudio cualitativo se llevó a cabo con 286 participantes. Los resultados arrojaron luz en cuanto a la recepción inicial de las soluciones tecnológicas desarrolladas dentro de un sistema de gestión del aprendizaje y en cuanto a la viabilidad de la informatización de la sección oral de la prueba, mostrando que es posible implan…
Is pain sensitivity altered in people with Alzheimer's disease? A systematic review and meta-analysis of experimental pain research
2016
Background Clinical studies suggest people with Alzheimer's disease (AD) have altered pain sensitivity. Experimental pain research is equivocal. Objective Conduct a meta-analysis to investigate if people with AD have altered pain sensitivity compared to healthy controls (HCs). Methods Three authors searched electronic databases from inception till November 2015 for experimental pain studies in AD vs. HCs. Outcome measures were pain threshold, tolerance, pain ratings, heart rate response to noxious stimuli and the Facial Action Coding System (FACS). Random effect meta-analysis calculating Hedges' g ± 95% confidence intervals (CI) was conducted. Results Thirteen studies were identified, inclu…
Preparation and Characterization of Novel Poly(alkylidenamine) Nitrile Ruthenium Metallodendrimers
2010
Complete functionalization of N,N,N',N'-[tetrakis(cyanoethyl)-hexamethylenediamine] [N≡C(CH 2 ) 2 ] 2 N(CH 2 ) 6 N[(CH 2 ) 2 -C≡N] 2 (4) and N,N,N',N'-(tetrakis(cyanoethoxypropyl)hexamethylenediamine] [N≡C(CH 2 ) 2 O(CH 2 ) 3 ] 2 N(CH 2 ) 6 N[(CH 2 ) 3 -O(CH 2 ) 2 C≡N] 2 (7) with the organometallic moiety [Ru(η 5 -C 5 H 5 )(PPh 3 ) 2 Cl] and the five-coordinate cis-[RuCl(dppe) 2 ]-[PF 6 ] [dppe = 1,2-bis(diphenylphosphanyl)ethane] was attained with good yield, respectively, by treating the metallo-fragment with the core in methanol (at room temperature and in presence of TIPF 6 as a chloride abstractor) and in 1,2-dichloroethane (under reflux). These novel nitrile-functionalized poly(alkyli…
Coexpression of inducible NO synthase and soluble guanylyl cyclase in colonic enterocytes: a pathophysiologic signaling pathway for the initiation of…
1998
Infectious diarrhea is often caused by the exotoxins of gram-negative bacteria such as Escherichia coli. However, these organisms also contain lipopolysaccharide (LPS) endotoxin. LPS induces nitric oxide synthase II (NOS II, inducible NOS) in various types of cells. We now demonstrate by RNase protection analysis, Western blot, and immunohistochemistry that the expression of NOS II mRNA and protein is markedly induced in colonic enterocytes of mice that ingest LPS with their drinking water. Using the same techniques, significant levels of soluble guanylyl cyclase (GC-S), the effector enzyme of NO, were found constitutively expressed in the mucosa. This creates a pathophysiologic autocrine p…
Chronic Diarrhea in a 5-Year-Old Girl: Pitfall in Routine Laboratory Testing with Potentially Severe Consequences
2009
A 5-year-old girl was referred because of recurrent watery diarrhea, abdominal pain, and flatulence. She was the second of 3 children. Her 10-year-old sister was normally developed and healthy. Her younger brother has meningomyelocele and hydrocephalus. At 1 year of age, the patient was admitted to the hospital for recurrent bronchitis, otitis media, food refusal, mild diarrhea, and abdominal distension since weaning. A sweat chloride analysis excluded cystic fibrosis. At that time, the patient’s laboratory results showed increased C-reactive protein (139 mg/L; reference interval, <5 mg/L) and moderate leukocytosis (14.6 × 109/L; reference interval, 4.5–13.5 × 109/L). Values for all other v…
Pre-service teachers’ experiences with a digital examination design: The inter-relation between continuity and change in an institutional context
2019
AbstractThis article reports a study of a full-scale digital examination in a five-year master program of teacher education in Norway. The innovative design involves observing a video case based on an authentic classroom situation and analysing the case in light of educational theory and subject content knowledge. All parts of this format are to be solved on a computer with Internet access. The study is centred on the pre-service teachers’ experiences of this open-ended and unfamiliar testing format. More specifically, the intention has been to analyse (a) what kinds of preparations they engaged in; (b) how they solved tasks during the examination; (c) their reflections on this mode of exam…
The Effect of Dexamethasone and Diuretics on Peritumor Brain Edema: Comparative Study of Tissue Water Content and CT
1976
Eighteen brain tumor patients were pre-operatively treated with dexamethasone, 4 × 4 mg i.m. for 4–6 days, and furosemide, 3 × 40 mg p.o. for 2–4 days. Water and electrolyte content were determined in biopsies removed from peritumoral cortex and white matter during operation and compared with the results from 31 patients not pre-treated and 28 patients treated with dexamethasone alone (16–24 mg i.m./day for 4–6 days). While the water content in cortex did not change significantly it fell in white matter from 79.90 ± 0.81 in untreated to 77.29 ± 0.76 in dexamethasone-treated and to 75.53 ± 1.03 in patients treated with a combination of dexamethasone and furosemide. With the diminution of wat…
Syndrome de la fissure orbitaire supérieure post-traumatique : mise au point
2016
The traumatic superior orbital fissure syndrome is an uncommon complication of craniomaxillofacial trauma. The diagnosis is clinical and associates ophtalmoplegia (constantly at initial clinical examination), ptosis and anaesthesia of the forehead. Young men victim of road traffic accidents are most often affected. CT-scan usually shows facial and/or craniofacial fractures more or less spreading towards the superior orbital fissure. The absence of fracture seen at the X-rays does not eliminate the diagnosis. Initial management should be multidisciplinary (maxillofacial surgeons, ophthalmologists and neurosurgeons) and conducted early if possible. It combines high-dose corticosteroids and de…