Search results for "Experimental validation"
showing 7 items of 37 documents
Molecular topology applied to the discovery of 1-benzyl-2-(3-fluorophenyl)-4-hydroxy-3-(3-phenylpropanoyl)-2H-pyrrole-5-one as a non-ligand-binding-p…
2014
We report the discovery of 1-benzyl-2-(3- fluorophenyl)-4-hydroxy-3-(3-phenylpropanoyl)-2H-pyrrole- 5-one as a novel non-ligand binding pocket (non-LBP) antagonist of the androgen receptor (AR) through the application of molecular topology techniques. This compound, validated through time-resolved fluorescence resonance energy transfer and fluorescence polarization biological assays, provides the basis for lead optimization and structure−activity relationship analysis of a new series of non-LBP AR antagonists. Induced-fit docking and molecular dynamics studies have been performed to establish a consistent hypothesis for the interaction of the new active molecule on the AR surface. Refereed/…
Cross-technology wireless experimentation: Improving 802.11 and 802.15.4e coexistence
2016
In this demo we demonstrate the functionalities of a novel experimentation framework, called WiSHFUL, that facilitates the prototyping and experimental validation of innovative solutions for heterogeneous wireless networks, including cross-technology coordination mechanisms. The framework supports a clean separation between the definition of the logic for optimizing the behaviors of wireless devices and the underlying device capabilities, by means of a unifying platform-independent control interface and programming model. The use of the framework is demonstrated through two representative use cases, where medium access is coordinated between IEEE-802.11 and IEEE-802.15.4 networks.
Generalisation and experimental validation of design rules for self-phase modulation-based 2R regenerators
2007
We report the design of 2R-regenerators based on self-phase modulation in lossy fibers. We experimentally demonstrate the applicability of the proposed scaling rules and present detailed characterization of the pulse characteristics at the regenerator output.
A Numerical Optimisation of a Stirling Engine
2011
International audience; A zero dimensional finite-time thermodynamic, three zones model of a generic Stirling engine has been developed and experimentally validated. Taking into account time-dependant heat transfers and losses, the model calculates the evolution of gas temperature, mass and pressure in each zone.
PEM FC Single Cell Based on a 3-D Printed Plastic Housing and Experimental Validation with the Mathematical Model
2018
Abstract This paper presents the design, modelling, and testing of a PEM single fuel cell based on the use of 3D printing. The design of the housings was made of SolidWorks, while MATLAB/SIMULINK were used to model performance. The fabricated cell performed satisfactorily with no leaks of gas, showing that the 3D printing method can be used in the additive manufacturing of fuel cells thus leading to significant cost savings.
Experimental validation of the prosthetic leg
2020
Abstract Studies of populations whose ability to perform voluntary movements is impaired due to natural reasons (e.g. aging), genetic anomaly (e.g. Down syndrome), trauma (e.g. spinal cord injury, amputation) or illness (e.g. Parkinson’s disease) frequently result in a basic question: are the observed motor patterns, which may be rather different from those seen in the general population, actually abnormal? In other words, should they be corrected? This question is important, not only for understanding the mechanisms of control over normal and disordered movements, but also for assessing the effectiveness of existing therapeutic approaches and providing focus for developing new therapies an…
Classification of SD-OCT Volumes Using Local Binary Patterns: Experimental Validation for DME Detection
2016
International audience; This paper addresses the problem of automatic classification of Spectral Domain OCT (SD-OCT) data for automatic identification of patients with Diabetic Macular Edema (DME) versus normal subjects. Optical Coherence Tomography (OCT) has been a valuable diagnostic tool for DME, which is among the most common causes of irreversible vision loss in individuals with diabetes. Here, a classification framework with five distinctive steps is proposed and we present an extensive study of each step. Our method considers combination of various pre-processings in conjunction with Local Binary Patterns (LBP) features and different mapping strategies. Using linear and non-linear cl…