Search results for "Experimental"
showing 10 items of 18236 documents
The nature of the syllabic neighbourhood effect in French
2006
International audience; We investigated whether and how sublexical units such as phonological syllables mediate access to the lexicon in French visual word recognition. To do so, two lexical decision task (LDT) experiments examined the nature of the syllabic neighbourhood effect. In Experiments 1a and b, the number of higher frequency syllabic neighbours was manipulated while controlling for the first bigram. The results failed to show a pure syllabic neighbourhood effect. In Experiments 2a and b, syllabic neighbourhood and bigram frequency were factorially manipulated. The interaction showed that the syllabic neighbourhood effect was inhibitory when bigram frequency was high, whereas it wa…
First measurement of quarkonium polarization in nuclear collisions at the LHC
2021
The polarization of inclusive J/$\psi$ and $\Upsilon(1{\rm S})$ produced in Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}=5.02$ TeV at the LHC is measured with the ALICE detector. The study is carried out by reconstructing the quarkonium through its decay to muon pairs in the rapidity region $2.5<y<4$ and measuring the polar and azimuthal angular distributions of the muons. The polarization parameters $\lambda_{\theta}$, $\lambda_{\phi}$ and $\lambda_{\theta\phi}$ are measured in the helicity and Collins-Soper reference frames, in the transverse momentum interval $2<p_{\rm T}<10$ GeV/$c$ and $p_{\rm T}<15$ GeV/$c$ for the J/$\psi$ and $\Upsilon(1{\rm S})$, respectively. The polarization parameter…
Influence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells
2009
The aryl hydrocarbon receptor (AhR) mediates toxicity of a variety of environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. However, the underlying mechanisms and genetic programmes regulated by AhR to cause adverse effects but also to counteract poisoning are still poorly understood. Here we analysed the effects of two AhR ligands, benzo[a]pyrene (B[a]P), a DNA damaging tumour initiator and promotor and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a pure tumour promoter, on cell survival and on nucleotide excision repair (NER) gene expression. NER deals with so called "bulky" DNA adducts including those generated by enzymatically activated B[a]P. Therefore, t…
Measurement of the average shape of longitudinal profiles of cosmic-ray air showers at the Pierre Auger Observatory
2019
The profile of the longitudinal development of showers produced by ultra-high energy cosmic rays carries information related to the interaction properties of the primary particles with atmospheric nuclei. In this work, we present the first measurement of the average shower profile in traversed atmospheric depth at the Pierre Auger Observatory. The shapes of profiles are well reproduced by the Gaisser-Hillas parametrization within the range studied, for E>10 17.8 eV .A detailed analysis of the systematic uncertainties is performed using ten years of data and a full detector simulation. The average shape is quantified using two variables related to the width and asymmetry of the profile, and …
Experimental evolution of an RNA virus in cells with innate immunity defects
2015
Experimental evolution studies have shown that RNA viruses respond rapidly to directional selection and thus can adapt efficiently to changes in host cell tropism, antiviral drugs, or other imposed selective pressures. However, the evolution of RNA viruses under relaxed selection has been less extensively explored. Here, we evolved vesicular stomatitis virus in mouse embryonic fibroblasts knocked-out for PKR, a protein with a central role in antiviral innate immunity. Vesicular stomatitis virus adapted to PKR-negative mouse embryonic fibroblasts in a gene-specific manner, since the evolved viruses exhibited little or no fitness improvement in PKR-positive cells. Full-length sequencing revea…
Evidence for Positive Selection in the Capsid Protein-Coding Region of the Foot-and-Mouth Disease Virus (FMDV) Subjected to Experimental Passage Regi…
2001
We present sequence data from two genomic regions of foot-and-mouth disease virus (FMDV) subjected to several experimental passage regimens. Maximum-likelihood estimates of the nonsynonymous-to-synonymous rate ratio parameter (dN/dS) suggested the action of positive selection on some antigenic sites of the FMDV capsid during some experimental passages. These antigenic sites showed an accumulation of convergent amino acid replacements during massive serial cytolytic passages and also in persistent infections of FMDV in cell culture. This accumulation was most significant at the antigenic site A (the G-H loop of capsid VP1), which includes an Arg-Gly-Asp (RGD) cellular recognition motif. Our …
Revised and short versions of the pseudoscientific belief scale
2021
This is the pre-peer reviewed version of the following article: Fasce, A, Avendaño, D, Adrián‐Ventura, J. Revised and short versions of the pseudoscientific belief scale. Appl Cognit Psychol. 2021; 1– 5, which has been published in final form at https://doi.org/10.1002/acp.3811. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. In this article, we develop the revised and short versions of the pseudoscientific belief scale through two empirical studies (N = 4154). This revision is motivated by the excessive length of the scale, as well as by consistent observations of poor item loadings across several studies…
Precision measurements in boosted top quarks in the ATLAS detector
2022
La presente tesis doctoral recoge principalmente una serie de estudios relacionados con la física del quark top, la partícula fundamental más pesada predicha teóricamente en el marco del Modelo Estándar y observada experimentalmente por los experimentos CDF y D0 en el acelerador de partículas Tevatron, en 1995. Debido a su gran masa, el quark top es de especial interés en la comunidad científica; entre otros, determina la estabilidad del vacío electrodébil junto con la masa del bosón de Higgs, introduce correcciones cuánticas grandes que modifican los cálculos del Modelo Estándar y podría ser especialmente sensible a efectos de física más allá del Modelo Estándar. Con todo ello, se han dedi…
Papel neuroprotector de las células mesenquimales humanas a nivel ocular en la esclerosis múltiple
2015
Entre las enfermedades neurodegenerativas del sistema nervioso central, la esclerosis múltiple (EM) es una enfermedad inflamatoria crónica considerada causa principal de discapacidad neurológica no traumática en el adulto joven. Los tratamientos actuales se basan en el uso de inmunosupresores para control de la inflamación en fases precoces. Estos tratamientos han demostrado la reducción en las tasas de recurrencia y actividad de la enfermedad, pero han tenido un impacto modesto en la progresión de la misma y la discapacidad asociada, sobre todo en formas agresivas. Modelos animales de EM han permitido recientemente estudiar el efecto de las hMSCs (células mesenquimales humanas) tras infusi…
New Insights Into Causal Pathways Between the Pediatric Age-Related Physical Activity Decline and Loss of Control Eating: A Narrative Review and Prop…
2020
Research consistently suggests that loss of control (LOC) eating in children and adolescents is a key factor contributing to pediatric obesity and eating disorders. However, causes of pediatric LOC eating are yet unclear, and there is a lack of longitudinal research investigating the developmental processes contributing to LOC eating and related outcomes in youth. Physical activity is an understudied behavior that declines during middle childhood to adolescence and may exert an influence in the development of LOC eating via its impact on executive functioning. While physical activity levels and executive functioning have been linked to regulation of eating, no research has examined the mech…