Search results for "Eye"
showing 10 items of 2511 documents
Comparative study of post-natal retinal vascular development in mice models of iPLA2 inhibition and plasmalogen deficiency
2012
Purpose: Plasmalogens are particular phospholipids characterized by the presence of a vinyl-ether bond and of a polyunsaturated fatty acid (PUFA) at sn-1 and sn-2 positions of glycerol, respectively. Even if the plasmalogen content of organs and tissues is well documented, their biological functions are still enigmatic. Plasmalogen deficiency in DAPAT-/- mice leads to developmental abnormalities in retinal vasculature (Acar et al, ARVO 2007 E-Abstract 2978) and to persistent hyaloïd arteries. We hypothesize that plasmalogens regulate retinal vascular development through the liberation of PUFA by a plasmalogen-specific calcium-independent phospholipase A2 (iPLA2). We have performed a compara…
The sleep EEG's microstructure in depression: alterations of the phase relations between EEG rhythms during REM and NREM sleep
2002
Abstract Objective : We investigated the microstructure of sleep electroencephalograms (EEGs) of 13 unmedicated depressive inpatients and 13 healthy controls matched in sex and age, hypothesizing that depressives depict an alteration of certain EEG oscillations across the night. Methods : We digitized the sleep EEGs with a sampling rate of 100Hz (bipolar derivation C z –P z , 1440 single sweeps; 2048 data points each), calculated the time course of delta (1–3.5Hz), theta (3.5–7.5Hz), alpha (7.5–15Hz), and beta (15–35Hz) activity over the night, and determined the correlation coefficients of these different EEG rhythms separately for rapid eye movement (REM) and non-rapid eye movement (NREM)…
A Real-World Study of Dexamethasone Implant in Treatment-Naïve Patients with Diabetic Macular Edema: Efficacy and Correlation Between Inflammatory Bi…
2020
Purpose There has been an increasing clinical interest in specific retinal parameters as non-invasive biomarkers of retinal inflammation in diabetic macular edema (DME) that have been shown to have prognostic value, such as hyperreflective retinal fields (HRFs) and subfoveal neuroretinal detachment (SND). Methods We conducted a prospective, non-comparative study of treatment-naive patients with DME to evaluate the efficacy of a Pro Re Nata (PRN) regimen of intravitreal dexamethasone implant 0.7 mg (DexI, Ozurdex™). After administration, patients underwent subsequent injections according to PRN criteria in case of edema relapse, but not earlier than 4 months after the previous treatment. Pat…
Cholesterol and ocular pathologies: focus on the role of cholesterol-24S-hydroxylase in cholesterol homeostasis
2015
The retina is responsible for coding the light stimulus into a nervous signal that is transferred to the brain via the optic nerve. The retina is formed by the association of the neurosensory retina and the retinal pigment epithelium that is supported by Bruch’s membrane. Both the physical and metabolic associations between these partners are crucial for the functioning of the retina, by means of nutrient intake and removal of the cell and metabolic debris from the retina. Dysequilibrium are involved in the aging processes and pathologies such as age-related macular degeneration, the leading cause of visual loss after the age of 50 years inWestern countries. The retina is composed of severa…
P258 Combining tDCS with prismatic adaptation for non invasive neuromodulation of the motor cortex
2017
Introduction Prismatic adaptation (PA) shifts visual field laterally and induces lateralized deviations of spatial attention. Recently, it has been suggested that prismatic goggles are also able to modulate brain excitability ( Magnani, 2014 ), with cognitive after-effects documented even in tasks not necessarily spatial in nature ( Oliveri, 2013 ). Objectives The aim of the present study was to test whether prisms can modulate motor cortical excitability similarly as anodal transcranial direct current stimulation (tDCS) does; to test whether neuromodulatory effects obtained from tDCS and prismatic goggles could interact and induce homeostatic changes in brain excitability. Materials and me…
New intraocular lens for achromatizing the human eye.
2007
To describe the design of a new intraocular lens (IOL) capable of correcting spherical and chromatic aberrations when implanted in the human eye.University of Murcia, Murcia, and University of Valencia, Valencia, Spain.A hybrid singlet achromatic IOL was designed. The IOL has a combination of a refractive and a diffractive surface, with 1 of the surfaces being aspherical. Optical simulations were used to model the polychromatic modulation transfer function (MTF) in pseudophakic eyes to explain the differences in optical quality afforded by the achromatic IOL. Parameters such as focus shift, optical path difference, through-focus, and robustness to tilt and decentering of achromatic IOLs wer…
Analysis of a soluble lipid-protein complex carrying endogenous 11-cis retinaldehyde from bovine retinal pigment epithelium.
1989
A soluble lipid-protein complex in bovine retinal pigment epithelium is shown to carry endogenous 11-cis retinaldehyde, in the extent of 15% of the total 11-cis retinaldehyde found in this tissue. The complex, analyzed with respect to its chemical composition, exhibits a lipid composition close resembling the lipid composition of the rod outer segment membrane; the SDS-PAGE evidences the presence of a number of protein bands, two of which of 34 and 27 kDa appear glycoproteins. Finally, the lipid-protein complex exhibits a discrete level of a Cathepsin D-like protease activity. From the above, the possibility is discussed that the soluble lipid-protein complex could represent some phagolysos…
The Effects of Melodic Grouping and Meter on Eye Movements during Simple Sight-Reading Tasks
2009
This study concerns the processes of eye movements during simple sight-reading tasks, concentrating on the processing of melodic groups separated by larger intervals and the effects of metrical placement of such groups. Thirty-two participants with varying musical background sight-read eight short melodies in two separate sessions. Eye movements during playing were recorded using an eye-tracker, and the performances on an electric piano with sequencer software. The melodies in question were of two types: melodic groupings were either aligned with the metrical divisions or made to overlap with them. The results indicate that reinspections to previously fixated notes during sight-reading incr…
Edukacja techniczna wsparciem rozwoju małej motoryki uczniów w młodszym wieku szkolnym
2018
Sprawność manualna dziecka rozwija się w toku różnorodnych ćwiczeń i zadań ruchowych usprawniających pracę mięśni drobnych oraz koordynację oka i ręki. Od tego, jaki poziom osiągnie dziecko w tym zakresie, zależy, między innymi, przebieg procesu nauki pisania oraz wykonania wszelkich prac manualnych, jednym z zadań edukacji technicznej w przedszkolu, a także w kształceniu wczesnoszkolnym jest rozwijanie motoryki niezbędnej do prawidłowego funkcjonowania dziecka w szkole i w życiu. Proces dochodzenia do biegłości w wykonywaniu precyzyjnych ruchów jest długotrwały i uwarunkowany zarówno cechami indywidualnymi, jak też przebiegiem i intensywnością ćwiczeń w tym zakresie. Przedmiotem poniższego…
Spatial Cognition 2020/1: Book of abstracts : August 2-4, 2021, University of Latvia
2021
Spatial Cognition is concerned with the acquisition, development, representation, organization, and use of knowledge about spatial objects in real, virtual or hybrid environments and processed by human or artificial agents. Spatial Cognition includes research from different fields insofar as they are concerned with cognitive agents and space, such as cognitive and developmental psychology, linguistics, computer science, geography, cartography, philosophy, neuroscience, and education. Research issues in the field range from the investigation of human spatial cognition to mobile robot navigation, including topics such as wayfinding, spatial planning, spatial learning, internal and external re…