Search results for "F2"

showing 10 items of 316 documents

Empirical measures and Vlasov hierarchies

2013

The present note reviews some aspects of the mean field limit for Vlasov type equations with Lipschitz continuous interaction kernel. We discuss in particular the connection between the approach involving the N-particle empirical measure and the formulation based on the BBGKY hierarchy. This leads to a more direct proof of the quantitative estimates on the propagation of chaos obtained on a more general class of interacting systems in [S.Mischler, C. Mouhot, B. Wennberg, arXiv:1101.4727]. Our main result is a stability estimate on the BBGKY hierarchy uniform in the number of particles, which implies a stability estimate in the sense of the Monge-Kantorovich distance with exponent 1 on the i…

MSC 82C05 (35F25 28A33)[PHYS.MPHY]Physics [physics]/Mathematical Physics [math-ph]FOS: Physical sciences01 natural sciencesVlasov type equation Mean-field limit Empirical measure BBGKY hierarchy Monge-Kantorovich distanceMathematics - Analysis of PDEs[MATH.MATH-MP]Mathematics [math]/Mathematical Physics [math-ph]FOS: Mathematics[MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP]Applied mathematicsMonge-Kantorovich distanceDirect proof0101 mathematicsEmpirical measureMathematical PhysicsMean field limitMathematicsNumerical AnalysisHierarchy010102 general mathematicsVlasov type equationMathematical Physics (math-ph)Empirical measureBBGKY hierarchyLipschitz continuity010101 applied mathematicsKernel (algebra)Uniqueness theorem for Poisson's equationBBGKY hierarchyModeling and SimulationExponent82C05 (35F25 28A33)Analysis of PDEs (math.AP)Kinetic & Related Models
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"Table 4" of "The A dependence of the nuclear structure function ratios"

1997

Additional normalisation error of 0.002 in the ratio.

MU- FE --> MU- XMU+ FE --> MU+ XF2InclusiveMU- C --> MU- XMU+ C --> MU+ XStructure FunctionNeutral CurrentDeep Inelastic ScatteringMU+ NUCLEUS --> MU+ XMU- NUCLEUS --> MU- XMuon production
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MEDIUM-TERM DETERMINANTS OF INTERNATIONAL INVESTMENT POSITIONS: THE ROLE OF STRUCTURAL POLICIES

2012

This paper provides an empirical investigation of the medium-term determinants of international investment positions for a large sample of advanced and emerging economies. In addition to the usually considered drivers of foreign assets and liabilities, the analysis focuses on the role of structural policy indicators. Using cross-section and panel regression techniques the results suggest that structural policy settings are important medium-term drivers of capital flows, having a relatively large impact on gross and net foreign capital positions and on their composition. In particular, the results suggest that certain kinds of structural policy reform could help to narrow global imbalances,…

MacroeconomicsEconomics and EconometricsInternational investmentInvestment PositionsForeign capitalGlobal imbalancesGeneral Business Management and AccountingMedium termF21 JEL Classifications: E6 [Capital flows structural policies global imbalances JEL Classifications]EconomicsCapital employedCapital flowsEmerging marketsFinancePanel dataJournal of International Commerce, Economics and Policy
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The Role of Risk and Information for International Capital Flows: New Evidence from the SDDS

2012

In this paper, we investigate whether better information about the macroeconomic environment of an economy has a positive impact on its capital inflows, namely portfolio and foreign direct investment (FDI). The purpose of our study is to explicitly quantify information asymmetries by compliance with the IMF's Special Data Dissemination Standard (SDDS). For FDI, we fi nd statistically signi cant and robust support for this hypothesis: SDDS subscription increased inflows by an economically relevant magnitude of about 60 percent. We also find evidence of aversion against political and macroeconomic risk as determinants of portfolio and FDI flows and use a non-parametric test for spatial correl…

Macroeconomicsmedia_common.quotation_subjectjel:F21Monetary economicsForeign direct investmentPortfolio investmentjel:C33Interest rateInformation asymmetryjel:G14determinants of capital flows; information; panel data; risk; SDDS; IMF; FDI; portfolio investment; spatial econometricsCapital (economics)EconomicsGeneral Earth and Planetary SciencesPortfolioEconomic modelSpatial econometricsGeneral Environmental Sciencemedia_commonPanel dataSSRN Electronic Journal
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Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas

2015

Fibroblast growth factor 21 (FGF21) is an important endocrine metabolic regulator expressed in multiple tissues including liver and adipose tissue. Although highest levels of expression are in pancreas, little is known about the function of FGF21 in this tissue. In order to understand the physiology of FGF21 in the pancreas, we analyzed its expression and regulation in both acinar and islet tissues. We found that acinar tissue express 20-fold higher levels than that observed in islets. We also observed that pancreatic FGF21 is nutritionally regulated; a marked reduction in FGF21 expression was noted with fasting while obesity is associated with 3–4 fold higher expression. Acinar and islet c…

Male0301 basic medicineFGF21Fibroblast Growth FactorPhysiologyReceptors Antigen T-Cell alpha-betaPeptide Hormoneslcsh:MedicineAdipose tissueAcinar CellsPathology and Laboratory MedicineBiochemistryFatsMiceEndocrinologyMedicine and Health SciencesInsulinlcsh:ScienceImmune ResponseMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Multidisciplinarygeography.geographical_feature_categoryFOXP3Forkhead Transcription FactorsFastingHyperplasiaIsletLipidsmedicine.anatomical_structurePhysiological ParametersOrgan SpecificityTumor necrosis factor alphaAnatomymedicine.symptomPancreasSignal TransductionResearch Articlemedicine.medical_specialtyImmunologyEndocrine SystemInflammationBiologyDiet High-FatInterferon-gammaIslets of Langerhans03 medical and health sciencesExocrine GlandsSigns and SymptomsGrowth FactorsInternal medicinemedicineAnimalsObesityPancreasNutritionInflammationDiabetic EndocrinologygeographyHyperplasiaEndocrine PhysiologyTumor Necrosis Factor-alphaBody Weightlcsh:RBiology and Life SciencesGlucagonmedicine.diseaseDietary FatsHormonesDietFibroblast Growth FactorsMice Inbred C57BL030104 developmental biologyEndocrinologyGene Expression RegulationPancreatitisThy-1 Antigenslcsh:QPLOS ONE
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Lean NAFLD: A Distinct Entity Shaped by Differential Metabolic Adaptation

2020

Background and Aims: Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the adult population. A significant subset of patients are lean, but their underlying pathophysiology is not well understood. Approach and Results: We investigated the role of bile acids (BAs) and the gut microbiome in the pathogenesis of lean NAFLD. BA and fibroblast growth factor (FGF) 19 levels (a surrogate for intestinal farnesoid X receptor [FXR] activity), patatin-like phospholipase domain containing 3 (PNPLA3), and transmembrane 6 superfamily member 2 (TM6SF2) variants, and gut microbiota profiles in lean and nonlean NAFLD were investigated in a cohort of Caucasian patients with biopsy-proven NAFLD (n …

Male0301 basic medicineReceptors Cytoplasmic and NuclearGut floraMice0302 clinical medicineNon-alcoholic Fatty Liver DiseaseFibrosisNonalcoholic fatty liver diseasebiologyMiddle AgedNAFLD; bile acids; fibrosis; gut microbiota; leanPhospholipases A2 Calcium-IndependentFemale030211 gastroenterology & hepatologyfibrosiAdultmedicine.medical_specialtydigestive systemBile Acids and SaltsCyclic N-Oxides03 medical and health sciencesThinnessInternal medicineNAFLDmedicinebile acidAnimalsHumansbile acidsHepatologygut microbiotabusiness.industryFGF15fibrosisnutritional and metabolic diseasesFGF19leanmedicine.diseasebiology.organism_classificationNAFLD fibrosis lean bile acids gut microbiotadigestive system diseasesGastrointestinal MicrobiomeFibroblast Growth FactorsMice Inbred C57BLDisease Models Animal030104 developmental biologyEndocrinologyFarnesoid X receptorSteatohepatitisbusinessTropanesTM6SF2
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Direct and indirect measurements of enhanced phenolic bioavailability from litchi pericarp procyanidins by Lactobacillus casei-01

2017

Litchi pericarp procyanidins (LPP) are dietary supplements with high antioxidant activity, but poor oral bioavailability and efficacy. Lactobacillus casei (L. casei-01) can transform flavan-3-ols from litchi pericarp and increase their antioxidant ability; thus, L. casei-01 with LPP was administered to rats for four and eight weeks to study the effect of such a combination on metabolic parameters and on phase II metabolism and detoxification pathways in the liver as an indirect measure for phenolic bioavailability. Our data indicated that the T-AOC of the plasma, the liver GSH-Px and GSH-ST activity, and the expression of UGT and SULT isoforms in the liver of the rats were all enhanced afte…

Male0301 basic medicineURINARY-EXCRETIONAntioxidantmedicine.medical_treatmentCHINENSIS PERICARPCatechinRats Sprague-DawleyBiotransformationIngestionFood scienceBiotransformationGENE-EXPRESSIONGlutathione TransferasebiologyChemistryfood and beverages04 agricultural and veterinary sciencesGeneral Medicine040401 food scienceLacticaseibacillus caseiLiverBiochemistryUDP-GLUCURONOSYLTRANSFERASE; PROTEASOMAL DEGRADATION; ANTIOXIDANT ACTIVITY; PROBIOTIC BACTERIA; CHINENSIS PERICARP; URINARY-EXCRETION; GENE-EXPRESSION; IN-VITRO; NRF2; POLYPHENOLSPROTEASOMAL DEGRADATIONPROBIOTIC BACTERIALactobacillus caseiAbsorption (skin)NRF203 medical and health sciencesPOLYPHENOLS0404 agricultural biotechnologyLitchiPhenolsDetoxificationmedicineAnimalsBiflavonoidsProanthocyanidinsGlutathione PeroxidasePlant ExtractsUDP-GLUCURONOSYLTRANSFERASEIN-VITRObiology.organism_classificationRatsBioavailabilitybody regionsTransformation (genetics)030104 developmental biologyFruitANTIOXIDANT ACTIVITYFood ScienceFood & Function
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SARS CoV2 infection _The longevity study perspectives

2021

Graphical abstract

MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2

2019

International audience; Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells with strong immunosuppressive activity that promote tumor growth. In this study, we describe a mechanism by which cancer cells control MDSCs in human cancers by upregulating TRF2, a protein required for telomere stability. Specifically, we showed that the TRF2 upregulation in cancer cells has extratelomeric roles in activating the expression of a network of genes involved in the biosynthesis of heparan sulfate proteoglycan, leading to profound changes in glycocalyx length and stiffness, as revealed by atomic force microscopy. This TRF2-dependent regulation facilitated the recruitment of MDSCs, their …

MaleHSPG;immunosurveillance;MDSC;NK cells;TRF2Mice NudeBiologyGlycocalyxGeneral Biochemistry Genetics and Molecular BiologyMetastasisGlycocalyx03 medical and health sciencesMice0302 clinical medicineDownregulation and upregulationNeoplasmsmedicineAnimalsHumansTelomeric Repeat Binding Protein 2STAT3Molecular BiologyCells Cultured030304 developmental biology0303 health sciencesGeneral Immunology and MicrobiologyGeneral NeuroscienceMyeloid-Derived Suppressor CellsArticlesTelomeremedicine.disease3. Good healthImmunosurveillanceGene Expression Regulation NeoplasticMice Inbred C57BLTLR2HEK293 CellsTumor progressionCancer cellCancer researchbiology.proteinNIH 3T3 Cells[SDV.IMM]Life Sciences [q-bio]/ImmunologyFemaleTumor Escape030217 neurology & neurosurgery
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Risk of chemotherapy-associated liver injury (CALI) in PNPLA3 p.148M allele carriers: Preliminary results of a transient elastography-based study

2019

Liver steatosis is one of the side effects of chemotherapy. The PNPLA3 p.I148M, TM6SF2 p.E167K and MBOAT7 p.G17E variants represent genetic determinants for progressive liver diseases. Here, we investigate their association with chemotherapy-associated steatosis.Prospectively, we recruited 87 patients undergoing systemic chemotherapy for gastrointestinal cancers. Hepatic fat (controlled attenuation parameter, CAP) and liver stiffness (LSM) were measured non-invasively before the initiation of chemotherapy (T0) and after at least two (T1) and four cycles (T2). Genetic variants were genotyped using allelic discrimination assays.In the final dataset (n = 60) patients demonstrated the following…

MaleHeterozygotemedicine.medical_specialtymedicine.medical_treatmentAntineoplastic AgentsGastroenterology03 medical and health sciences0302 clinical medicineFat accumulationInternal medicinemedicineHumansGenetic Predisposition to DiseaseAdiponutrinProspective StudiesAlleleeducationAllelesTriglyceridesAgedLiver injuryChemotherapyeducation.field_of_studyPolymorphism GeneticHepatologybusiness.industryGastroenterologyMembrane ProteinsLipaseMiddle Agedmedicine.diseaseFatty LiverLiver030220 oncology & carcinogenesisElasticity Imaging TechniquesFemale030211 gastroenterology & hepatologySteatosisTransient elastographybusinessAcyltransferasesTM6SF2Digestive and Liver Disease
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