Search results for "F2"
showing 10 items of 316 documents
What Can International Finance Add to International Strategy?
2011
This chapter focuses on the role of corporate financial strategies to improve firms’ market valuations, and thus lower their cost of capital. The identification of successful strategies is accomplished within an overall strategic framework and related to how the firm perceives the degree of international financial integration. Five strategies for how to break out of a segmented, thin domestic capital market are highlighted together with historical success cases. The chapter illustrates the linkages between business strategy, firm motivation, and various financial strategies. JEL: F21, F23, F36, G32, G34.
Identification of molecular pathophysiological mechanisms of non-alcoholic fatty liver disease (NAFLD)
2018
Alkohola neizraisītā taukaino aknu slimība (NATAS) ietver plaša spektra izmaiņas aknās: no pārmērīgas tauku uzkrāšanās līdz pat cirozei. NATAS ģenētiskās komponentes noteikšanai tika veikta visa genoma asociāciju pētījumus (GWAS). Polimorfismi Pnpla3 (I148M; rs738409) un Tm6sf2 (E167K; rs58542926) gēnos ir asociēti ar paaugstinātu lipīdu uzkrāšanos aknās. PNPLA3 I148M varianta proteīns pastiprināti uzkrājas uz šūnu tauku lodīšu virsmas, kas traucē tauku lodīšu normālu funkciju. Proteīna TM6SF2 167K variants izraisa proteīna nestabilitāti un ātrāku tā degradāciju. Tālākie pētījumi parāda, ka TM6SF2 ir saistīts ar aknu ļoti zema blīvuma lipoproteīnu (VLDL) veidošanu vai ekskrēciju. Izpratne p…
Unvolvement of calcium signaling and MAP kinases in lipid taste perception
2013
In this work, we demonstrate that stromal interaction molecule 1 (STIM1), a sensor of Ca2+ depletion in the endoplasmic reticulum, mediates fatty acid–induced Ca2+ signaling in the mouse tongue and fat preference. We showed that linoleic acid (LA) induced the production of arachidonic acid (AA) and lysophosphatidylcholine (Lyso-PC) by activating multiple phospholipase A2 isoforms via CD36. This activation triggered Ca2+ influx in lingual CD36-positive taste bud cells (TBCs) purified from mouse CVP. LA also induced the production of Ca2+ influx factor (CIF). STIM1 was found to regulate LA-induced CIF production and the opening of store-operated Ca2+ (SOC) channels. Furthermore, CD36-positive…
Identidad contra identidades: el destino contra Babelia
1997
El impulso de los nacionalismos y la constatación de la crisis ecológica global, son fenómenos paradójicos y contradictorios. En base a las contribuciones desde la sociología de Eisenstadt y Geisen, y desde el derecho y la teoría política de Wendt y Falk, nosotros argumentamos que el concepto de identidad planetaria, al tiempo que se opone conceptualmente al babelismo nacionalista dominante en ciertos sectores intelectuales, puede cimentar las bases para un entendimiento racional del devenir en este fin de siglo. Nationalism and environmental global conscience are contradictory ideas. We argue in this paper, using as a source from the sociological point of view the work of Eisenstadt and Gi…
Kinetics of the electronic center annealing in Al2O3 crystals
2018
Authors are greatly indebted to A. Ch. Lushchik, V. Kortov, M. Izerrouken and R.Vila for stimulating discussions. This work has been carried out within the framework of the Eurofusion Consortium and has received funding from the Euroatom research and training programme 2014–2018 under grant agreement No 633053 . The views and opinions expressed herein do not necessarily reflect those of the European Commission. The calculations were performed using facilities of the Stuttgart Supercomputer Center (project DEFTD 12939 ).
Study of the f(2)(1270) , f(2)'(1525) , f(0)(1370) and f(0)(1710) in the J/psi radiative decays
2009
In this paper we present an approach to study the radiative decay modes of the J/psi into a photon and one of the tensor mesons f (2)(1270) , f' (2)(1525) , as well as the scalar ones f (0)(1370) and f (0)(1710) . Especially, we compare predictions that emerge from a scheme where the states appear dynamically in the solution of vector meson-vector meson scattering amplitudes to those from a (admittedly naive) quark model. We provide evidence that it might be possible to distinguish amongst the two scenarios, once improved data are available.
Detection of charged pions and protons in the segmented electromagnetic calorimeter TAPS
1998
We present the characteristics of the segmented BaF2 calorimeter TAPS for the measurement of charged pions and protons. The method of particle identification exploits the relation between the kinetic energy of a particle, its mass and the time-of-flight required to reach the detector. The detection efficiency is calculated using GEANT-GCALOR simulations. The analysis method is applied in the reaction Ar-40 + Ca-nat at 0.8A GeV. The simultaneous detection of charged pions and protons can be used to search for correlated pairs signalling the de-excitation of the Delta(1232) resonance. (C) 1998 Elsevier Science B.V. All rights reserved.
Learning from foreign operation modes: The virtuous path for innovation
2020
In this article, we analyze the impact of learning from internationalization on small and medium enterprises’ (SMEs) performance along different development paths. Drawing on the exploitation versus exploration logic, we use an alternative view of foreign operation modes (the learning perspective) to provide insights into the impact of such learning on technological and organizational innovation as well as overall performance. Our results, which are derived from a sample of 132 SMEs active in traditional manufacturing industries, point to a path to superior performance that entails resource-augmenting operation modes and organizational innovation. JEL CLASSIFICATION: O31; F23; L25; M10; M1…
The burden of hepatocellular carcinoma in non-alcoholic fatty liver disease: Screening issue and future perspectives
2019
In recent decades, non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in the Western world, and the occurrence of its complications, such as hepatocellular carcinoma (HCC), has rapidly increased. Obesity and diabetes are considered not only the main triggers for the development of the disease, but also two independent risk factors for HCC. Single nucleotide polymorphisms (such as PNPLA3, TM6SF2 and MBOAT7) are related to the susceptibility to the development of HCC and its progression. Therefore, an appropriate follow-up of these patients is needed for the early diagnosis and treatment of HCC. To date, international guidelines recommend the use of ultrasonogr…
Global and sex-specific epigenome-wide association studies for the identification of the main methylated loci related to smoking in a mediterranean p…
2019
Abstract Background Tobacco use has been reported to be the main cause of 90% of male and 80% of female lung cancers, as well as a relevant risk factor for other cancers such as oropharynx, larynx, esophagus, stomach, liver, pancreas, kidney, bladder, and colorectum. Smoking directly affects DNA methylation and although several genes have been reported to be differentially methylated in smokers, gender differences and population-specific differences remain to be further investigated. Our aim was to undertake global and sex-specific genome-wide epigenomic studies (EWAS) in a Mediterranean population to identify the main smoking DNA-methylated genes. Methods We analyzed 88 participants in the…