Search results for "FAD"
showing 10 items of 292 documents
N-attiecības ietekme uz izdzīvotību pacientiem ar kuņģa vēzi pēc gastrektomijām ar paplašinātām limfadenektomijām
2021
Ievads: N-attiecība ir prognostisks rīks, kas spēj samazināt TNM stadijas uzliktās stadijas migrāciju. Atbilstoši N-attiecība spētu papildināt esošo TNM klasifikācijas sistēmu tādējādi būtu iespējams samazināt nepareizas stadijas uzlikšanu. Darba mērķis: Izpētīt limfmezglu attiecības ietekmi uz izdzīvotību pacientiem ar kuņģa vēzi pēc gastrektomijām ar paplašinātām limfadenektomijām. Darba uzdevumi: Iepazīties ar jaunāko literatūtu, ievākt pacientu datus no 2014 - 2015 gada, apkopot klīniski-patoloģiskos faktorus veikt šo faktoru analīzi un veikt secinājumus. Rezultāti: Pētījums rāda, ka N-attiecības un pN rādītāja 5 gadu izdzīvotība ir līdzvērtīga. Tika konstatēts, ka N-attiecība ir progno…
A ricardian analysis of the impact of climate change on permanent crops in a mediterranean region
2019
This is the first study which explores the impact of climate change in Sicily, a small Mediterranean region of Southern Europe. According to research, Mediterranean area has shown large climate shifts in the last century and it has been identified as one of the most prominent “Hot-Spots” in future climate change projections. Since agriculture is an economic activity which strongly depends on climate setting and is particularly responsive to climate changes, it is important to understand how such changes may affect agricultural profitability in the Mediterranean region. The aim of the present study is to assess the expected impact of climate change on permanent crops cultivated in Sicilian r…
Last tesserae of a fading mosaic: floristic census and forest vegetation survey at Parche di Bilello (south-western Sicily, Italy), a site needing ur…
2021
This paper illustrates the botanic heritage of Parche di Bilello, a site located in the municipality of Castelvetrano. The study area hosts several woodland fragments dominated by Olea europaea var. sylvestris, Quercus suber and Quercus ilex, respectively. According to historical data, these nuclei represent the last remnants of an open forestland which covered a much wider coastal area between Mazara del Vallo and Sciacca until the end of Middle Age. Phytosociological relevés were focused on these forest nuclei, probably the most representative of south-western Sicily, which correspond to three habitats included in the 92/43 EEC Directive (9320, 9330 and 9340, respectively) and represent t…
Are sacred caves still safe havens for the endemic bats of Madagascar?
2018
AbstractDespite conservation discourses in Madagascar increasingly emphasizing the role of customary institutions for wildlife management, we know relatively little about their effectiveness. Here, we used semi-structured interviews with 54 adults in eight villages to investigate whether sacred caves and taboos offer conservation benefits for cave-dwelling bats in and around Tsimanampetsotsa National Park, south-west Madagascar. Although some caves were described as sites of spiritual significance for the local communities, most interviewees (c. 76%) did not recognize their present-day sacred status. Similarly, only 22% of the interviewees recognized taboos inhibiting bat hunting and consum…
Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP
2020
Resistance of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis represents the major hurdle to the clinical use of TRAIL or its derivatives. The discovery and development of lead compounds able to sensitize tumor cells to TRAIL-induced cell death is thus likely to overcome this limitation. We recently reported that marine actinomycetes&rsquo
Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary…
2020
Many early studies presented beneficial effects of polyunsaturated fatty acids (PUFA) on cardiovascular risk factors and disease. However, results from recent meta-analyses indicate that this effect would be very low or nil. One of the factors that may contribute to the inconsistency of the results is that, in most studies, genetic factors have not been taken into consideration. It is known that fatty acid desaturase (FADS) gene cluster in chromosome 11 is a very important determinant of plasma PUFA, and that the prevalence of the single nucleotide polymorphisms (SNPs) varies greatly between populations and may constitute a bias in meta-analyses. Previous genome-wide association studies (GW…
A dual role of caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development.
2017
Summary Concomitant hepatocyte apoptosis and regeneration is a hallmark of chronic liver diseases (CLDs) predisposing to hepatocellular carcinoma (HCC). Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated DNA damage. Proliferation-associated replication stress, DNA damage, and genetic instability are detectable in CLDs before any neoplastic changes occur. Accumulated levels of hepatocyte apoptosis determine and predict subsequent hepatocarcinogenesis. Proliferation-associated DNA damage is sensed by a complex comprising caspase-8, FADD, c-FLIP, and a kinase-dependent function of RIPK1. This platform requires a non-apop…
Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation.
2017
Cholestatic liver injury results from impaired bile flow or metabolism and promotes hepatic inflammation and fibrogenesis. Toxic bile acids that accumulate in cholestasis induce apoptosis and contribute to early cholestatic liver injury, which is amplified by accompanying inflammation. The aim of the current study was to evaluate the role of the antiapoptotic caspase 8-homolog cellular FLICE-inhibitory (cFLIP) protein during acute cholestatic liver injury. Transgenic mice exhibiting hepatocyte-specific deletion of cFLIP (cFLIP−/−) were used for in vivo and in vitro analysis of cholestatic liver injury using bile duct ligation (BDL) and the addition of bile acids ex vivo. Loss of cFLIP in h…
A Geometrical Channel Model for MIMO Mobile-to-Mobile Fading Channels in Cooperative Networks
2009
This paper deals with the modeling and analysis of narrowband multiple-input multiple-output (MIMO) mobile- to-mobile (M2M) fading channels in relay-based cooperative networks. Non-line-of-sight (NLOS) propagation conditions are assumed in the transmission links from the source mobile station to the destination mobile station via the mobile relay. A stochastic narrowband MIMO M2M reference channel model is derived from the geometrical three-ring scattering model, where it is assumed that an infinite number of local scatterers surround the source mobile station, the mobile relay, and the destination mobile station. The complex channel gains associated with the new reference channel model are…
A Geometrical Three-Ring-Based Model for MIMO Mobile-to-Mobile Fading Channels in Cooperative Networks
2011
Published version of an article published in the journal: Eurasip Journal on Advances in Signal Processing. Also available from the publisher at: http://dx.doi.org/10.1155/2011/892871. OA This paper deals with the modeling and analysis of narrowband multiple-input multiple-output (MIMO) mobile-to-mobile (M2M) fading channels in relay-based cooperative networks. In the transmission links from the source mobile station to the destination mobile station via the mobile relay, non-line-of-sight (NLOS) propagation conditions are taken into account. A stochastic narrowband MIMO M2M reference channel model is derived from the geometrical three-ring scattering model, where it is assumed that an infi…