6533b872fe1ef96bd12d3a64

RESEARCH PRODUCT

Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome.

Judith B. Ramírez-sabioJosé V SorlíJosé V. SorlíCarolina Ortega-azorínCarolina Ortega-azorínIgnacio M. Gimenez-albaIgnacio M. Gimenez-albaDolores CorellaDolores CorellaEva C. PascualRamon EstruchRamon EstruchEva M. AsensioEva M. AsensioJose M. OrdovasJose M. OrdovasJose M. OrdovasVicente Zanon-morenoVicente Zanon-morenoOscar ColtellOscar ColtellRocío BarragánRocío BarragánJosé I. GonzálezJosé I. González

subject

0301 basic medicineFatty Acid DesaturasesMaleSíndrome metabòlicaDiet MediterraneanMediterranean populationchemistry.chemical_compoundDelta-5 Fatty Acid DesaturaseÀcids grassos saturatsRisk Factorsgeneticschemistry.chemical_classificationMetabolic Syndromeeducation.field_of_studyClinical Trials as TopicNutrition and DieteticsbiologyMiddle AgedPhenotypeTreatment OutcomeFemaleomega-3mediterranean populationlcsh:Nutrition. Foods and food supplypolyunsaturated fatty acidsPolyunsaturated fatty acidmedicine.medical_specialtyomega-6FADS1Fatty Acid ElongasesLinoleic acidPopulationlcsh:TX341-641Single-nucleotide polymorphismGenetic polymorphismsPolymorphism Single NucleotideArticlemetabolic syndrome03 medical and health sciencesSex FactorsInternal medicineFatty Acids Omega-6Fatty Acids Omega-3medicinesexHumansGenetic Predisposition to DiseaseSaturated fatty acidseducationAgedgenome-wide association study030109 nutrition & dieteticsPolimorfisme genèticFatty acidmedicine.disease030104 developmental biologyFatty acid desaturaseEndocrinologyCross-Sectional StudieschemistrySpainbiology.proteinGene-Environment InteractionheterogeneityMetabolic syndromepolymorphismsFood ScienceGenome-Wide Association Study

description

Many early studies presented beneficial effects of polyunsaturated fatty acids (PUFA) on cardiovascular risk factors and disease. However, results from recent meta-analyses indicate that this effect would be very low or nil. One of the factors that may contribute to the inconsistency of the results is that, in most studies, genetic factors have not been taken into consideration. It is known that fatty acid desaturase (FADS) gene cluster in chromosome 11 is a very important determinant of plasma PUFA, and that the prevalence of the single nucleotide polymorphisms (SNPs) varies greatly between populations and may constitute a bias in meta-analyses. Previous genome-wide association studies (GWAS) have been carried out in other populations and none of them have investigated sex and Mediterranean dietary pattern interactions at the genome-wide level. Our aims were to undertake a GWAS to discover the genes most associated with serum PUFA concentrations (omega-3, omega-6, and some fatty acids) in a scarcely studied Mediterranean population with metabolic syndrome, and to explore sex and adherence to Mediterranean diet (MedDiet) interactions at the genome-wide level. Serum PUFA were determined by NMR spectroscopy. We found strong robust associations between various SNPs in the FADS cluster and omega-3 concentrations (top-ranked in the adjusted model: FADS1-rs174547, p = 3.34 &times

yearjournalcountryeditionlanguage
2020-01-24
10.3390/nu12020310http://hdl.handle.net/20.500.12105/13170