Search results for "FAME"
showing 10 items of 61 documents
Simultaneous dissolution profiles of two drugs in pharmaceutical formulations by an FIA manifold
2002
Abstract This article deals with the simultaneous determination of dissolution profiles of two drugs with overlapped spectra, present in the same pharmaceutical formulation. The official procedure for the dissolution profile is adapted to the continuous-flow methodology; the dissolution vessel is connected to an FIA manifold, in which the sample aliquots from the dissolution vessel are treated in order to adjust to the suitable pH and dilution degree to be monitored. The resulting solution is injected into the carrier stream, an acetic acid–acetate buffer at pH 4.3 and forced to the flow-cell of the spectrophotometer. The simultaneous determination of both profiles is based on the first der…
Occurrence of antibiotics in the aquatic environment
1999
The recent monitoring of drug residues in the aquatic environment has gained much interest as many pharmaceutical compounds can frequently be found in sewage treatment plant (STP) effluents and river water at concentrations up to several microgram/l. This article describes the analysis of various water samples for 18 antibiotic substances, from the classes of macrolid antibiotics, sulfonamides, penicillins and tetracyclines. Samples were preconcentrated via lyophilization and quantified using HPLC-electrospray-tandem-mass spectrometry. The investigated STP effluents and surface water samples showed frequent appearance of an erythromycin degradation product, roxithromycin and sulfamethoxazol…
Pérdida aparente y cuantitativa de ácidos grasos y especies de triglicéridos a temperatura de fritura
2012
[EN]: Olive and sunflower oils were heated at 180 °C for 5, 10 and 15 hours with the aim of defining the changes in the contents of fatty acid methyl esters (FAME) and triacylglycerols (TAG) under frying conditions. Differences between apparent and real loss of FAME or TAG are defined for an adequate interpretation of the changes taking place at high temperature. Such differences depend on the expression of the results and frequently result in erroneous conclusions. Results showed that from the normalized composition it could be deduced that only the most unsaturated FAME (C18:2) or TAG containing it was significantly altered. However, quantitative data indicated that all the unsaturated FA…
Occurrence of antibiotics and risk of antibiotic resistance evolution in selected Kenyan wastewaters, surface waters and sediments
2019
Active pharmaceutical ingredients, especially antibiotics, are micropollutants whose continuous flow into hydrological cycles has the potential to mediate antibiotic resistance in the environment and cause toxicity to sensitive organisms. Here, we investigated the levels of selected antibiotics in four wastewater treatment plants and the receiving water bodies. The measured environmental concentrations were compared with the proposed compound-specific predicted no-effect concentration for resistance selection values. The concentration of doxycycline, amoxicillin, sulfamethoxazole, trimethoprim, ciprofloxacin and norfloxacin within the influents, effluents, surface waters and river sediments…
Prefazione a Messina, R., "La strage negata"
2016
"Il 19 ottobre del 1944 si consumò a Palermo uno degli eventi più drammatici dell'immediato dopoguerra: truppe dell'esercito italiano aprirono il fuoco su centinaia di cittadini che, al grido di 'pane, pasta e lavoro!', sfilavano per il centro della città in una pacifica protesta contro il carovita. 24 tra i manifestanti, e tra di loro bambini e ragazzi, rimasero uccisi; 156 furono feriti. [...] Ripercorrendo tutte le tappe dell'iter giudiziario dell'eccidio del 19 ottobre, e concentrandosi in particolare sull'analisi del processo svoltosi presso il tribunale militare di Taranto nel febbraio del 1947, Rino Messina ci dimostra come dietro il paravento della "tutela dell'ordine pubblico" si n…
Automated simultaneous triple dissolution profiles of two drugs, sulphamethoxazole-trimethoprim and hydrochlorothiazide-captopril in solid oral dosag…
2003
This article deals with the simultaneous determination of three dissolution profiles with the aid of the new and emerging continuous-flow methodology known as multicommutation. This methodology is based on a flow network of a set of solenoid valves controlled by the computer and acting as independent multicommutators to allow the easy and automated control of flowing solutions. The obtained three dissolution profiles from one dosage form are the whole formulation profile or "global profile" recommended by pharmacopoeias, and, at same time, are recorded two "individual" profiles from two drugs present in the formulation. This is the second attempt to obtain simultaneously three dissolution p…
Wideoblog - przyczyny popularności (stanowisko twórcy i odbiorcy)
2017
Punktem wyjściowym rozważań autorka uczyniła definicję pojęcia „wideoblog”. Główny nacisk położyła na sprecyzowanie i omówienie przyczyn, dla których jednostki zamieszczają autorskie materiały audiowizualne w Internecie. Poprzez poznanie motywacji twórców można wytłumaczyć, skąd bierze się tak duża popularność tego typu materiałów. Autorka zwróciła uwagę między innymi na to, jakie czynniki mogą być pomocne dla osiągnięcia sławy w Sieci. Dla lepszego zobrazowania omawianego w tekście tworu zaprezentowała parę sylwetek popularnych obecnie vlogerów oraz odwołała się do ich działalności w Sieci. Wielu youtuberów osiąga sławę nie tylko w przestrzeni Internetu, ale również poza nim. Jako że jest …
Un grande filologo e la Grande guerra. Perifrasi del concetto di fame di Leo Spitzer, cento anni dopo
2019
Il giovane romanista Leo Spitzer pubblica al principio degli anni Venti del Secolo scorso tre opere fondamentali per la linguistica italiana, due delle quali strettamente legati alla sua esperienza di direttore di un gruppo di censori della corrispondenza dei prigionieri italiani in Austria-Ungheria in occasione della Prima guerra mondiale. Una di queste ha al centro la varia congerie delle designazioni della fame in tali lettere, tema che era appunto sottoposto al rigido controllo della censura. Recentemente tradotta in italiano e pubblicata con il corredo di apparati e introduzioni, l'opera viene esaminata in questo articolo da una prospettiva non solo dialettologico-variazionista, ma anc…
La ejemplaridad de la muerte y la inmortalidad del saber en la literatura sapiencial medieval
2022
El origen escriturario de la muerte como castigo es el punto de partida de su ejemplaridad que, basada en presupuestos teológicos, le imprimió un halo de penitencia, que se perfila en todos los órdenes de actuación y convivencia del ser humano, en aras de conseguir el perdón y retornar a la gracia divina. En este trabajo se analizan los diferentes motivos que proyectan la ejemplaridad de la muerte en el ámbito de la literatura sapiencial: muerte física y muerte espiritual; trascendencia y sentencia del alma; el hecho maravilloso (milagros, premoniciones, relevaciones o visiones); el miedo (y lo macabro) ligado al arquetipo de la muerte transida y sus plasmaciones en variados tópicos (mement…
Emerging drugs for the treatment of vitiligo.
2020
Introduction: Vitiligo is a relatively common autoimmune depigmenting disorder of the skin. There has been a great advance in understanding the pathological basis, which has led to the development and utilization of various new molecules in treating vitiligo. This review aims at a comprehensively describing the treatments available and the emerging treatment aspects and the scope for future developments.Areas covered: This study comprehensively summarizes the current concepts in the pathogenesis of vitiligo with special focus on the cytokine and signaling pathways, which are the targets for newer drugs. JAK kinase signaling pathways and the cytokines involved are the focus of vitiligo treat…