Search results for "FARM"

Incidenza della mutazione rs12979860 del gene di IL28 in un gruppo di soggetti HCV positivi dell’U.O.C. di Malattie infettive del P.O. Civico di Pale…

L'infezione cronica da HCV colpisce 170 milioni di persone in tutto il mondo;su 100 persone infettate dal virus HCV il 15% non sviluppa alcuna patologia cronica ed elimina il virus, il restante 85% sviluppa forme croniche della malattia con evoluzione in cirrosi epatica e in carcinoma epato-cellulare.Il trattamento dell'epatite C cronica, che offre i maggiori vantaggi, è rappresentato da un ciclo di 24-48 settimane di PEG-Interferone-alfa-2a e Ribavirina. Il suo esito è influenzato da una serie di fattori tra cui il genotipo virale ed alcuni polimorfismi genetici dell’ospite I pazienti infetti da HCV di genotipo 2 o 3 hanno probabilità 2-3 volte maggiore di rispondere alla terapia rispetto …

Conservation value of forest plantations for bird communities in western Kenya

2008

Tree plantations of native and exotic species are frequently used to compensate for forest loss in the tropics. However, these plantations may support lower species diversity and different communities than natural forest. We therefore investigated bird communities in stands of natural forest, different types of tree plantations and secondary forest in Kakamega Forest, western Kenya. We compared birds differing in habitat specialisation, i.e. forest specialists, generalists, and visitors. We recorded significant differences in mean species richness and number of individuals among the different forest types. Stands of natural forest and plantations of indigenous tree species comprised more sp…

High seedling recruitment of indigenous tree species in forest plantations in Kakamega Forest, western Kenya

2009

Tree plantations are often used to compensate for the destruction and conversion of natural forests in the tropics. An important question is whether these plantations allow for the regeneration of indigenous tree species and are expected to transform into more natural forests in the future. To evaluate the potential of differently managed forest types for seedling recruitment of indigenous tree species we studied structural characteristics as well as tree and seedling communities in stands of natural forest, different types of tree plantations and secondary forest in Kakamega Forest, western Kenya. Forest types differed considerably in structural characteristics and tree composition with st…

Meža melleņu antocianīnu ekstrakta bioloģisko efektu izpēte intervences pētījumā geriatrijas pacientiem

2020

Dažādos zinātniskos pētījumos antocianīni uzrāda augstus antioksidatīvos efektus, pretiekaisuma iedarbību, kā arī spēju samazināt kardiovaskulāro slimību risku. Cilvēka organismam novecojot pieaug oksidatīvais stress un tā radītie bojājumi sekmē arī iekaisuma procesu veidošanos, vienlaikus paaugstinot hronisko saslimšanu riskus geriatrijas vecuma cilvēkiem. Darba mērķis bija noskaidrot meža melleņu antocianīnu ekstraktu saturoša uztura bagātinātāja intervences ietekmi, apskatot ar novecošanos saistītu asins bioķīmisko marķieru izmaiņas geriatrijas pacientiem. Rezultāti liecina, ka pēc 4 nedēļu meža melleņu antocianīnu ekstrakta kapsulu lietošanas 2 reizes dienā (50 mg/kaps.) ir droša geriat…

COVID-19 Pandemic: New Prevention and Protection Measures

2022

As of the end of February 2021, more than 420,000,000 confirmed cases of COVID-19 have been reported worldwide, with 5,856,224 deaths. Transmission of the different genetically engineered variants of SARS-CoV-2, which have been isolated since the beginning of the pandemic, occurs from one infected person to another by the same means: the airborne route, indirect contact, and occasionally the fecal–oral route. Infection is asymptomatic or may present with flulike symptoms such as fever, cough, and mild to moderate and severe respiratory distress, requiring hospitalization and assisted ventilation support. To control the spread of COVID-19, the World Health Organization (WHO) and Centers for …

Monitorización e individualización posológica de glucocerebrosidasa en pacientes con enfermedad de Gaucher Tipo I

2018

La enfermedad de Gaucher tipo I (EG1) es una enfermedad de depósito lisosomal causada por una deficiencia de la enzima glucocerebrosidasa, cuyo tratamiento consiste en la reposición mediante la administración exógena de la enzima deficiente, denominada terapia enzimática sustitutiva(TES). Actualmente, existe una gran controversia y una elevada variabilidad en la dosificación de la TES y en los regímenes utilizados en la práctica clínica debido a la amplia variabilidad observada en la respuesta a la TES; además las modificaciones de dosis para objetivar respuesta al tratamiento se alargan entre 12-24 meses, en una terapia con un elevado impacto económico al sistema nacional de salud. Sin emb…

Neirotrofo faktoru ekspresija streptozocīna - Alcheimera slimības modelī ar muscimolu

2016

1906. gadā vācu psihiatrs un neiropatologs Aloīzs Alcheimers pirmo reizi aprakstīja 56 gadu vecumā mirušu pacienti, kura mira neskaidras slimības dēļ, pēdējo četru gadu laikā strauji zaudējot atmiņu un dažādas iemaņas. Laika gaitā, analizējot medicīniskos pierakstus un pētot mirušās pacientes smadzenes, tika noteikta amiloīdo plātņu un neirofibrilāro mezglu esamība smadzenēs, kas tika nosaukta par Alcheimera slimību (Engstrom, 2007). Alcheimera slimība ir progresējoši smadzeņu darbības traucējumi, kā rezultātā smadzenes pakāpeniski „noārdās”. Visbiežāk tā rodas cilvēkiem 65-70 gadu vecumā. Slimības attīstības gaitā attīstās negatīvas izmaiņas atmiņā, domāšanā, dažādās darbībās un uzvedībā, …

Drug release from α,β-poly(N-2-hydroxyethyl)-DL-aspartamide based microparticles

2004

Spherical pH-sensitive microparticles have been prepared by reverse phase suspension polymerization technique. Starting polymer has been alpha,beta-poly(N-2-hydroxyethyl)-dl-aspartamide (PHEA) partially derivatized with glycidylmethacrylate (GMA). PHEAGMA copolymer (PHG) has been crosslinked in the presence of acrylic acid (AA) or methacrylic acid (MA) at various concentration. The obtained microparticles have been characterized by FT-IR spectrophotometry, particle size distribution analysis and scanning electron microscopy. In order to have information about water affinity of the prepared samples, swelling measurements have been carried out in aqueous media which simulate some biological f…

HSV-1 Glycoprotein D and Its Surface Receptors: Evaluation of Protein–Protein Interaction and Targeting by Triazole-Based Compounds through In Silico…

2023

Protein–protein interactions (PPI) represent attractive targets for drug design. Thus, aiming at a deeper insight into the HSV-1 envelope glycoprotein D (gD), protein–protein docking and dynamic simulations of gD-HVEM and gD-Nectin-1 complexes were performed. The most stable complexes and the pivotal key residues useful for gD to anchor human receptors were identified and used as starting points for a structure-based virtual screening on a library of both synthetic and designed 1,2,3-triazole-based compounds. Their binding properties versus gD interface with HVEM and Nectin-1 along with their structure-activity relationships (SARs) were evaluated. Four [1,2,3]triazolo[4,5-b]pyridines were i…

COUPLING ELECTROCHEMISTRY TO ELECTROSPRAY: A NOVEL PREPARATION OF GOLD NANOSTRUCTURES

2013

nanoparticles on ITO (Indium tin oxide) coated glass using the electrospray (ESI) method Method:The starting point of this study is that the ESI/MS spectrum (Figure 1) of an ethanolic solution of HAuCl 4 shows a reduction process of Au (III) strongly dependent on the Cone Voltage (CV) values (20, 80, 150 V), affording to the ion at m/z 197 (Au+). Further, the decrease of the abundance of this ion at the highest cone voltage suggests the subsequent its reduction with the formation of Au 0 . Figure 1: ESI/MS spectra of an ethanolic solution of HAuCl4 at various cone voltages: Conclusion: Such experimental evidence leads us to use electrospray technique as a preparative tool to obtain the form…