Search results for "FARMACEUTICO"

ATTIVITÀ ANTIBATTERICA DI UNA SOLUZIONE OLEOSA: possibili applicazioni nell’industria alimentare per la prevenzione della formazione di biofilm

2014

Le malattie che derivano dal consumo di alimenti hanno sempre minacciato la salute umana. Oggi il loro aumento è diventato un problema per salute pubblica, emergente in tutto il mondo. Molte di queste malattie sono state associate alla presenza di biofilm batterici, comunità microbiche complesse, nell’industria alimentare. Il biofilm è diventato un grosso problema per l’industria della lavorazione del pesce, del latte e derivati, del pollame, della carne e dei cibi “pronti da mangiare”, perché, in seguito alla sua formazione, i batteri a esso associati sono particolarmente resistenti agli agenti antimicrobici e alle operazioni di pulizia. Anche se fino ad oggi sono ancora utilizzate, e sono…

Oregano essential oils activity against Listeria monocitogenes biofilms

2015

Ocular Drug Delivery Systems per la veicolazione di molecole bioattive al segmento posteriore dell'occhio

Buccal delivery in treatment of Alzheimer disease: enhancement of galantamine absorption

2009

CURCUMIN-LOADED LIPID NANOSTRUCTURES AS DRUG DELIVERY SYSTEMS.

2009

Characterization Of Casein-Loaded Proteoliposomes, Potential Inhibitors In Amyloid Fibrillogenesis

Casein-loaded proteoliposomes: Drug Delivery Systems and Potential Inhibitors in Aβ1-40 Fibrillogenesis

2018

Alzheimer's disease (AD) represents the most common cause of dementia worldwide. The early symptom is usually a short-term memory loss, followed by symptoms including problems with language, disorientation, mood swings, loss of motivation, not managing self-care, and behavioral issues, until loss of body functions and, ultimately, death. The cause of AD is poorly understood and the diagnosis is complex. One of the main AD hallmarks is the extracellular deposition in brain tissue of proteinaceous amyloid plaques, composed by well-ordered fibrillary aggregates of the amyloid β-peptide (Aβ). The Aβ aggregation process follows typical nucleation-polymerization kinetics, characterized by structu…

Controlled Drug delivery in Parkinson's Disease - Progress beyond the state-of-the-art

2009

A new dopamine amino-acid conjugate: preclinical in vitro studies and evaluation of behavioural effects in rats

2012

It is well established that alterations in the functionality of dopaminergic transmission are associated with neurodegenerative diseases such as Parkinson’s Disease. The purpose of this study was to investigate the activity of a new dopamine amino-acid conjugate: L-phenylalanine-β-(3,4-dihydroxyphenyl) etilamide(DA-Phe) in the central nervous system, by assessing its influence on different behavioural parameters in the rat. Preliminarily, we tested the in vitro stability in plasmatic environment following the disappearance of DA-Phen from human plasma and the concurrent appearance of dopamine. Using rat brain homogenate, we also evaluated the level of DA-Phen cleavage by cerebral enzymes an…

Development of stimulus-sensitive electrospun membranes based on novel biodegradable segmented polyurethane as triggered delivery system for doxorubi…

2022

In this work, redox-sensitive polyurethane urea (PUU) based electrospun membranes have been exploited to chemically tether a pH-sensitive doxorubicin derivative achieved by linking a lipoyl hydrazide to the drug via a hydrazone linkage. First, the lipoyl-hydrazone-doxorubicin derivative labelled as LA-Hy-Doxo has been syn- thesized and characterized. Then, the molecule has been tethered, via a thiol-disulfide exchange reaction, to the redox-sensitive PUU (PolyCEGS) electrospun membrane. The redox-sensitive PolyCEGS PUU has been produced by using PCL-PEG-PCL polyol and glutathione-tetramethyl ester (GSSG-OMe)4 as a chain extender. The LA-Hy- Doxo tethered electrospun membrane has showed a du…