6533b870fe1ef96bd12cfc76
RESEARCH PRODUCT
Development of stimulus-sensitive electrospun membranes based on novel biodegradable segmented polyurethane as triggered delivery system for doxorubicin
Salvatore FedericoAnnalisa MartoranaGiovanna PitarresiFabio Salvatore PalumboCalogero FioricaGaetano Giammonasubject
Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoDoxorubicinPolyurethanesPolyurethane Stimuli-responsive polymers Electrospun membrane Doxorubicin Lipoic acidCancer therapyHydrazonesHumansAntineoplastic AgentsMicellesdescription
In this work, redox-sensitive polyurethane urea (PUU) based electrospun membranes have been exploited to chemically tether a pH-sensitive doxorubicin derivative achieved by linking a lipoyl hydrazide to the drug via a hydrazone linkage. First, the lipoyl-hydrazone-doxorubicin derivative labelled as LA-Hy-Doxo has been syn- thesized and characterized. Then, the molecule has been tethered, via a thiol-disulfide exchange reaction, to the redox-sensitive PUU (PolyCEGS) electrospun membrane. The redox-sensitive PolyCEGS PUU has been produced by using PCL-PEG-PCL polyol and glutathione-tetramethyl ester (GSSG-OMe)4 as a chain extender. The LA-Hy- Doxo tethered electrospun membrane has showed a dually controlled release triggered by acidic and reducing conditions, producing a significant cytotoxic effect in human breast cancer cell lines (MCF-7) which has validated the system for the post-surgical treatment of solid tumors to contrast recurrence
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-05-01 | Biomaterials Advances |