Search results for "FATE"

Improvement of Resveratrol Permeation through Sublingual Mucosa: Chemical Permeation Enhancers versus Spray Drying Technique to Obtain Fast-Disintegr…

2021

Resveratrol (RSV) is a natural polyphenol with several interesting broad-spectrum pharmacological properties. However, it is characterized by poor oral bioavailability, extensive first-pass effect metabolism and low stability. Indeed, RSV could benefit from the advantage of the sublingual route of administration. In this view, RSV attitudes to crossing the porcine sublingual mucosa were evaluated and promoted both by six different chemical permeation enhancers (CPEs) as well as by preparing four innovative fast-disintegrating sublingual mini-tablets by spray drying followed by direct compression. Since RSV by itself exhibits a low permeation aptitude, this could be significantly enhanced by…

PGI19 Stress Ulcer Bleeding Prophylaxis with Proton Pump Inhibitors, H2 Receptor Antagonists or Sucralfate: A Cost-Effectiveness Analysis

2011

Sulphate-reducing bacteria in paper machine waters and in suction roll perforations

1978

To define some aspects of the biological corrosion sulphate-reducing bacteria were studied in paper machine waters and in plugged perforations of a suction roll. The desulphuricants were most active on passive fiber recipients. Most bacteria found in fiber plugs taken from the perforations of suction rolls belonged to the genus Desulfovibrio. Desulphuricants were found mainly at the outer ends of plugged perforations, where corrosion of the roll metal is most evident.

Inhibitoren der Korrosion (9) Nachweis der Sekundärinhibitoren bei einigen Sulfoxiden, Triphenylarsinoxid und einigen Sulfoniumsalzen

1971

Die Schutzwerte von Dibenzylsulf-oxyd und strukturell verwandten Ver-bindungen sowie von Triphenylarsin-oxyd werden bestimmt. Sulfoxyde und Arsinoxyde werden (a) nach Protonierung in die kathodischen Bereiche gefuhrt und (b) nach Elektronenaufnahme in die ko-ordinationsfahigen Sekundarinhibitoren (Thioather und tert. Arsine) umgewan-delt. Die Sekundarinhibitoren ziehen entweder auf das Metall auf und unter-drucken dann die Auflosung des Eisens oder werden nicht am Metall fixiert (z. B. Diphenylsulfid) und entfalten dann keinen Schutz. Im Falle des Dibenzyl-sulfoxyds konnen ca. 90% des einge-setzten Dibenzylsulfoxyds als Dibenzyl-sulfid vom Eisen abgelost werden; 16% an unverandertem Dibenzy…

Baeyer—Villiger Oxidation in Supercritical CO2 with Potassium Peroxomonosulfate Supported on Acidic Silica Gel.

2006

Supercritical carbon dioxide (scCO2) is an efficient reaction medium to perform the Baeyer-Villiger oxidation with hydrated silica-supported potassium peroxomonosulfate (h-SiO2.KHSO5) under flow-through conditions. Hydration modulates the reactivity of the active surface by softening the acidity of the KHSO4 present in the supported reagent. The reaction in scCO2 is much more efficient than in n-hexane under similar conditions, which is attributed to better transport and solvating properties of the supercritical medium with regard to n-hexane.

Incorporation of trace metals Cu, Zn, and Cd into gypsum: Implication on their mobility and fate in natural and anthropogenic environments

2020

Abstract The coexistence of calcium (Ca2+), sulfate (SO42−) with trace metal cations (M(II)) can possibly lead to M(II)-gypsum coprecipitation and solid solution formation. However, gypsum's role in the fixation of M(II) is still largely unknown. This study investigated the precipitation of Ca2+ and SO42− in the presence of M(II) (i.e., Cu2+, Zn2+, or Cd2+) and the incorporation of the metal cations into the gypsum structure at different environmental conditions. Trace metals in two natural gypsum samples (Yunnan and Neimeng, China) and one hydrometallurgical byproduct gypsum sample from a Cu refinery were also assessed. X-ray diffraction, scanning electron microscopy-energy dispersive X-ra…

Surface-exposed Amino Acid Residues of HPV16 L1 Protein Mediating Interaction with Cell Surface Heparan Sulfate

2007

Efficient infection of cells by human papillomaviruses (HPVs) and pseudovirions requires primary interaction with cell surface proteoglycans with apparent preference for species carrying heparan sulfate (HS) side chains. To identify residues contributing to virus/cell interaction, we performed point mutational analysis of the HPV16 major capsid protein, L1, targeting surface-exposed amino acid residues. Replacement of lysine residues 278, 356, or 361 for alanine reduced cell binding and infectivity of pseudovirions. Various combinations of these amino acid exchanges further decreased cell attachment and infectivity with residual infectivity of less than 5% for the triple mutant, suggesting …

The effect of detergents on the basement membrane complex of a biologic scaffold material

2013

The basement membrane complex (BMC) is a critical component of the extracellular matrix (ECM) that supports and facilitates the growth of cells. This study investigates four detergents commonly used in the process of tissue decellularization and their effect upon the BMC. The BMC of porcine urinary bladder was subjected to 3% Triton-X 100, 8 mM 3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate (CHAPS), 4% sodium deoxycholate or 1% sodium dodecyl sulfate (SDS) for 24 h. The BMC structure for each treatment group was assessed by immunolabeling, scanning electron microscopy (SEM) and second harmonic generation (SHG) imaging of the fiber network. The composition was assessed by quantif…

Oleuropein protects against dextran sodium sulfate-induced chronic colitis in mice.

2013

The anti-inflammatory effect of oleuropein (1), the major phenolic secoiridoid in Olea europaea, was evaluated in an experimental model of chronic colitis in mice. Animals were exposed to four repeated cycles of dextran sodium sulfate in drinking water followed by a 7-day rest period. Animals receiving a standard diet supplemented with 0.25% of 1 (equivalent to 500 mg/kg/day) for 56 days exhibited a decrease of inflammatory symptoms, as reflected by improvement of disease activity index and histopathological changes. It was found that 1 decreased inflammatory cell recruitment and the release of inflammatory cytokines interleukin (IL)-1β and IL-6 with increased IL-10 levels in colon tissue. …

Energetics of Water−Dodecyl Surfactant−Macrocyclic Compound Ternary Systems

1996

Enthalpies of dilution and osmotic coefficients of sodium dodecyl sulfate (NaDS) and dodecyltrimethylammonium bromide (DTAB) in water + 18-crown-6 ether (CR) and water + β-cyclodextrin (CD) at a fixed cosolvent concentration were measured at 298 and 310 K, respectively, as functions of the surfactant concentration (mS). Enthalpies of transfer ΔH (W → W + S) of CR (0.03 m) from water to NaDS and DTAB aqueous solutions as functions of mS were also determined at 298 K. From the enthalpies of dilution the apparent (LΦ,S) and partial (L2,S) molar relative enthalpies of both surfactants were calculated. Despite CR forms inclusion complexes with the anionic surfactant only, the L2,S vs mS profiles…