Search results for "FEV1"

Versican and collagen-III expression in bronchial and pulmonary muscular arteries in COPD patients

2015

Background: We demonstrated that COPD patients have thicker bronchial and pulmonary muscular arteries (MA) compared with never and non-obstructed smokers. The composition of the extracellular matrix of these altered MA has been not fully described. Objectives: To investigate the expression of versican and collagen-III in bronchial and pulmonary MA in the lungs of mild/moderate COPD patients. Methods: Eighteen mild/moderate COPD subjects (67±8y, FEV 1 : 67±15%pred), 14 non-obstructed smokers (64±8y, FEV 1 : 95±10%pred) and 11 never-smoking controls (CTRL) (51±12y, FEV 1 : 108±15%pred) were studied. Lung tissue obtained during surgery (ethical approval obtained) was used to analyze the expres…

Dažādu astmas vērtēšanas parametru korelācija: plaušu funkcija (FEV), NO izelpas gaisā (FeNO) un eozinofīlu skaits asinīs.

2018

Mūsu pētījuma galvenais mērķis bija novērtēt korelāciju starp dažādiem astmas vērtēšanas parametriem, piemēram, forsētās izelpas tilpumu pirmās sekundes laikā (FEV1), frakcionēto slāpekļa oksīdu slāpekļa oksīdu (FeNO) un eozinofilo leikocītu skaitu venozās asinīs pacientiem ar bronhiālo astmu, lietojot inhalējamo kortikosteroīdu ārstēšanā. Pētījuma tika iekļauti 180 pacienti vecumā no 18 līdz 75 gadiem, ar astmas diagnozi un atgriezenisku obstrukciju, kuri tika ārstēti ar 2.-4. ārstēšanas soli atbilstoši Globālās astmas iniciatīvas (GINA) vadlīnijām. Pētījuma populācijā bija 108 sievietes un 72 vīrieši. No kuriem 114 bija nesmēķētāji, 30 bijušie smēķētāji un 36 smēķētāji. 108 pacienti jeb 6…

Accuracy assessment of fraction of vegetation cover and leaf area index estimates from pragmatic methods in a cropland area

2009

The fraction of vegetation cover (FVC) and the leaf area index (LAI) are important parameters for many agronomic, ecological and meteorological applications. Several in-situ and remote sensing techniques for estimating FVC and LAI have been developed in recent years. In this paper, the uncertainty of in-situ FVC and LAI measurements was evaluated by comparing estimates from LAI-2000 and digital hemispherical photography (DHP). The accuracy achieved with a spectral mixture analysis algorithm and two vegetation indices-based methods was assessed using atmospherically corrected Landsat Thematic Mapper (TM) data over the Barrax cropland area where the European Space Agency (ESA) SENtinel-2 and …

Direct validation of FVC, LAI and FAPAR VEGETATION/SPOT derived products using LSA SAF methodology

2007

The aim of this work is to perform a direct validation of fraction of vegetation cover (FVC), leaf area index (LAI) and fraction of absorbed photosynthetically active radiation (FAPAR) resulting products from applying the LSA SAF methodology to VEGETATION BRDF data. LSA SAF adapted algorithms were tested in adequate test sites comprising different continental biomes covering a wide range of FVC, LAI and FAPAR values. Results seem to indicate the competitiveness of LSA SAF proposed methodology to retrieve remotely sensed biophysical parameters. A noticeable good agreement regarding the ground measurements was found. The overall accuracy (RAISE) is around 20% for FVC and FAPAR and around 15% …

Modifications in FVC during AMP Induced Bronchoconstriction in Asthma: Relationship with the Response to Methacholine and Influence of Inhaled Cortic…

2009

Heritability of Lung Function: A Twin Study Among Never-Smoking Elderly Women

2011

Most studies on lung function heritability have been conducted in smokers and non-smokers using cross-sectional study design. Smoking patterns may, however, confound the contribution of genetic factors. We investigated heritability of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio longitudinally, excluding the effects of smoking. A sample of never smoking female twins (n = 374), aged 63–76 at baseline, answered health questionnaires and attended spirometry in years 2000 and 2003. Bivariate structural equation modeling, restricted to adequate spirometry performances (baseline n = 339, follow-up n = 252), was used to estimate genetic and environ…

IκB kinase-driven nuclear factor-κB activation in patients with asthma and chronic obstructive pulmonary disease.

2011

Background Nuclear factor-κB (NF-κB) is a transcriptional factor of different inflammatory patterns involved in asthma and chronic obstructive pulmonary disease (COPD) that is tightly controlled by IκB kinase (IKK) complex. Objective We investigated the dysregulation of IKK-driven NF-κB activation in patients with asthma and COPD. Methods We assessed IKKα and IKKβ expression and activation, their regulation by glucocorticosteroids, and their involvement in IL-8 synthesis in PBMCs isolated from asthmatic patients, healthy smokers (HSs), patients with COPD, and control subjects. PBMCs from control subjects were stimulated with TNF-α and cigarette smoke extract in the presence or absence of fl…

Efecto del pedaleo de brazos sobre el sistema cardiorrespiratorio de las personas con tetraplejia. (Effect of armcrank pedaling on the cardiorespirat…

2010

Objetivos: Determinar el efecto de un programa de entrenamiento de pedaleo de brazos (PB) estacionario, sobre el sistema cardiorrespiratorio de personas con tetraplejia. Metodo: Se estudiaron 11 participantes con tetraplejia por lesion medular (LM) de origen traumatico a niveles entre C4 y C6. Se midieron variables espirometricas (VC, FVC y MVV) y de Variabilidad de la Frecuencia Cardiaca VFC (HR, STDHR, RMSSD, LF, HF y HRVPOWER), antes y despues de 8 semanas de entrenamiento. Resultados: Todas las variables mostraron cambios significativos (p < 0,05) despues del programa de entrenamiento aumentando su valor, excepto la FC que disminuyo. Las personas con las LM mas bajas mostraron valores m…

Prevalence and 30-Day Mortality in Hospitalized Patients With Covid-19 and Prior Lung Diseases.

2021

Patients with pre-existing respiratory diseases in the setting of COVID-19 may have a greater risk of severe complications and even death.A retrospective, multicenter, cohort study with 5847 COVID-19 patients admitted to hospitals. Patients were separated in two groups, with/without previous lung disease. Evaluation of factors associated with survival and secondary composite end-point such as ICU admission and respiratory support, were explored.1,271 patients (22%) had a previous lung disease, mostly COPD. All-cause mortality occurred in 376 patients with lung disease (29.5%) and in 819 patients without (17.9%) (Previous lung disease is a risk factor for mortality in patients with COVID-19.…

Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)

2020

According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored al…