Search results for "FLE"
showing 10 items of 3517 documents
In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges
2020
Flexible spikes The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein enables viral entry into host cells by binding to the angiotensin-converting enzyme 2 (ACE2) receptor and is a major target for neutralizing antibodies. About 20 to 40 spikes decorate the surface of virions. Turoňová et al. now show that the spike is flexibly connected to the viral surface by three hinges that are well protected by glycosylation sites. The flexibility imparted by these hinges may explain how multiple spikes act in concert to engage onto the flat surface of a host cell. Science, this issue p. 203
In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges
2020
AbstractThe spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is required for cell entry and is the major focus for vaccine development. We combine cryo electron tomography, subtomogram averaging and molecular dynamics simulations to structurally analyze Sin situ. Compared to recombinant S, the viral S is more heavily glycosylated and occurs predominantly in a closed pre-fusion conformation. We show that the stalk domain of S contains three hinges that give the globular domain unexpected orientational freedom. We propose that the hinges allow S to scan the host cell surface, shielded from antibodies by an extensive glycan coat. The structure of native S contr…
Valutazione partecipata e continuità nei servizi educativi zero-sei: una ricerca-intervento in un quartiere della città di Palermo
2021
RIASSUNTO In questo articolo verrà condotta inizialmente una riflessione sulla funzione della valutazione di contesto sia in termini formativi individuali e di gruppo, sia in termini di cambiamento organizzativo, adottando una prospettiva ecologica e sistemica. Successivamente, attraverso la narrazione di un percorso di ricerca sulla costruzione di un possibile curricolo zero-sei, condotta per tre anni con un gruppo di insegnanti di scuola dell’infanzia statale ed un gruppo di educatrici di un nido comunale operanti nello stesso territorio (un quartiere del centro storico di Palermo), verranno messi in luce e problematizzati ambiti di continuità e di discontinuità tra i due servizi educativ…
INCLUSIVE PEDAGOGY AND TEACHER TRAINING TOWARDS HIGH QUALITY EDUCATION PROCESSES.A RESEARCH WITH FUTURE SUPPORT TEACHERS
2022
Fornire un’educazione di qualità, equa ed inclusiva e opportunità di apprendimento per tutti è la base per migliorare la vita delle persone e raggiungere lo sviluppo sostenibile. Forte degli insegnamenti trattidagli Obiettivi di Sviluppo del Millennio (OSM), l’obiettivo 4 dell’Agenda 2030 non si limita all’istruzione primaria, ma fotografa in modo completo tutti i passi che sono necessari per garantire, in ogni parte del mondo, un'educazione di qualità, equa e accessibile a tutti. In tale contesto è fondamentale una particolare attenzione allo sviluppo delle competenze degli insegnanti e della loro capacità riflessiva e di lettura critica della propria esperienza professionale. Gli approcci…
Indagine diagnostica non invasiva sul dipinto su tavola l'Annunciata di Antonello da Messina
2007
SHIPPING 4.0: GENERAL FRAMEWORK FOR A NEW CYBERSHIPPING ERA
2019
The fourth industrial revolution, also referred to as Industry 4.0, is a disruptive transformation process aimed which, by means of digital technologies, is substantially innovating the value creation processes in all industry contexts. With such premise, industry 4.0 is in particular expected to have a substantial impact on the maritime transport and shipping sectors, where smart ships and autonomous vessels are expected to be the building blocks of a new interconnected maritime ecosystem. The application of Industry 4.0 principles to the shipping domain (Shipping 4.0) has thus raised a scientific debate about the efficiency, sustainability, and safety of maritime transport. Recent researc…
La jornada continua como un recurso para la maternidad intensiva. Una mirada desde la Comunidad Valenciana
2021
La “ideología de la maternidad intensiva” (Hays, 1998) según la cual la prioridad de la madre es dar respuesta a las necesidades de los hijos e hijas mediante la inversión de grandes cantidades de recursos económicos, temporales y emocionales, proporciona en este artículo una perspectiva clarificadora para comprender mejor el apoyo de un gran número de familias a la jornada continua en las escuelas. El artículo representa una primera aproximación a la relación entre maternidad intensiva y jornada escolar, a partir de la reflexión teórica que suscita la bibliografía existente sobre la construcción social de la maternidad, los análisis realizados sobre la jornada escolar en el ámbito español …
Appendix – Additional Measurements
2016
This appendix deals with the determination of different soil physical and hydraulic characteristics used in the analysis and/or interpretation of the infiltration experiments. The core method and the excavation method for measurement of soil bulk density are initially presented. Determination of soil water content by the thermo-gravimetric and the Time Domain Reflectometry methods is then illustrated. Subsequently, field measurement of soil water matric potential by tensiometers is discussed. Laboratory determination of the soil water retention curve by tensiometric and pressiometric techniques is also described. Finally, different methods to test water stability of soil aggregates are illu…
Augmenting the algorithm: emerging human-in-the-loop work configurations
2020
Abstract How do configurations of humans and algorithms evolve as firms adopt artificial intelligence (AI) capabilities, and what are the implications for work and organization? We explored these questions through a two-year long case study of an organization in the international maritime trade that introduced automated algorithmic support for data analysis and prediction work. Drawing on a human–machine configuration perspective, we found that humans and the algorithm were configured and reconfigured in multiple ways over time as the organization dealt with the introduction of algorithmic analysis. In contrast to replacing human work, the emergent configurations required new roles and redi…
2020
Abstract Interest in studying information systems discontinuance has been increasing lately, yet there is no consensus on what it means. To improve the situation, we conduct a comprehensive review of current literature on IS discontinuance and identify 55 studies published during 1991–2017 that specifically focus on the topic. Our conceptual analysis disentangles the process, content, and context of the phenomenon, revealing that over the course of a typical IS lifecycle, IS discontinuance may materialize at least in five distinct forms: rejection, regressive discontinuance, quitting, temporary discontinuance, and replacement. After elaborating their distinctions, we discuss their theoretic…