Search results for "FN"
showing 10 items of 862 documents
Fractional Derivatives in Interval Analysis
2017
In this paper, interval fractional derivatives are presented. We consider uncertainty in both the order and the argument of the fractional operator. The approach proposed takes advantage of the property of Fourier and Laplace transforms with respect to the translation operator, in order to first define integral transform of interval functions. Subsequently, the main interval fractional integrals and derivatives, such as the Riemann–Liouville, Caputo, and Riesz, are defined based on their properties with respect to integral transforms. Moreover, uncertain-but-bounded linear fractional dynamical systems, relevant in modeling fractional viscoelasticity, excited by zero-mean stationary Gaussian…
Role of alternative food networks in Sicilian farms
2014
Today the short supply chain can be carried out through several typologies which are called as alternative food networks (AFNs). In fact, according to some studies, it is an 'alternative' response to the dominant agro-food system, which offers the possibility to produce food products through supply chains that are opposed to long, complex and rationally organised industrial chains. In the last years many European farmers adopted short supply chain to commercialise their agro-food products and Italy is one of the EU members in which AFNs are developed, thanks to its numerous typical an local products. The aim of this paper has been to analyse the role that AFNs play in Sicilian farms and how…
Analysis of different geometrical features to achieve close-to-bone stiffness material properties in medical device: A feasibility numerical study
2021
Background and objective: In orthopedic medical devices, elasto-plastic behavior differences between bone and metallic materials could lead to mechanical issues at the bone-implant interface, as stress shielding. Those issue are mainly related to knee and hip arthroplasty, and they could be responsible for implant failure. To reduce mismatching-related adverse events between bone and prosthesis mechanical properties, modifying the implant's internal geometry varying the bulk stiffness and density could be the right approach. Therefore, this feasibility study aims to assess which in-body gap geometry improves, by reducing, the bulk stiffness. Methods: Using five finite element models, a unia…
Layer-wise and equivalent single layer models for smart multilayered plates
2014
Layer-wise and equivalent single layer plate models for magneto-electro-elastic multiphysics laminates are presented in a unified framework. They are based on variable kinematics and quasi-static behavior of the electromagnetic fields. The electromagnetic state of each single layer is preliminary determined by solving the corresponding governing equations coupled with the proper interface continuity and external boundary conditions. By so doing, the electromagnetic state is condensed into the plate kinematics and the layer governing equations are inferred by the principle of virtual displacements. This approach identifies effective mechanical layers, which are kinematically equivalent to th…
A case of disseminated BCG infection in a daughter of Italian immigrants in Switzerland
2022
Bacillus Calmette-Guérin (BCG) is a vaccine against tuberculosis and contains a live, attenuated strain of Mycobacterium bovis as its essential constituent. Being a live, attenuated strain with potential pathogenicity, BCG can cause different complications, both near the inoculation site and through blood dissemination, especially in patients with immunodeficiency. IFN-γR1 deficiency is an autosomal recessively inherited immunodeficiency characterized by predisposition to infections with intracellular pathogens, in particular mycobacteria.
 We report a rare case of chronic osteomyelitis lasting 30 years due to BCG in a woman with IFN-γR1 deficiency who had previous clinical history of …
Effect of Oral Semaglutide on Cardiovascular Parameters and Their Mechanisms in Patients with Type 2 Diabetes: Rationale and Design of the Semaglutid…
2022
Type 2 diabetes (T2D) management has reached a point where not only optimal glycaemic control is necessary, but also additional interventions with proven cardiovascular risk reduction benefit. Subcutaneous semaglutide has been shown to provide cardiovascular protection, but its use may be limited by its injection formulation. To overcome this limitation, an oral semaglutide tablet has been developed, which could potentially be of the same value as its injection counterpart, but in a much wider group of patients with T2D, thereby allowing for broader cardiovascular risk reduction in this vulnerable patient population.A total of 100 consecutive patients with T2D and a disease duration of up t…
Cause, pathogenesis, clinical manifestations and treatment of meniere's disease and endolymphatic hydrops
2019
Meniere's disease (MD) is characterized by the triad of fluctuating hearing loss, episodic vertigo and tinnitus, and by endolymphatic hydrops found on postmortem examinations. Since the description of endolymphatic hydrops by Hallpike and Cairns all the physiopathology of Meniere's symptoms have been based on assumption that the pathologic lesion was the cause of the symptoms. Paparella came out term and concept towards understanding of a disease was, "pathogenesis," which applies to all otological diseases, in general and in particular within this context of MD, which allows us to better understand this disease. After Schuknecht proposed the theory of membranous rupture causing the mixing …
Meniere's disease: Therapeutic options
2021
Meniere's disease (MD) is characterized by the triad of fluctuating hearing loss, episodic vertigo and tinnitus, and by endolymphatic hydrops found on postmortem examinations. Since the description of endolymphatic hydrops by Hallpike and Cairns, the physiopathology of Meniere's symptoms has been based on assumption that the pathologic lesion was the cause of the symptoms. Schuknecht proposed the theory of membranous rupture causing the mixing up of endolymph and perilymph leading to the occurrence of Meniere's symptoms. Lawrence confirmed this theory with research on experimental animals. In 1995 the AAO-HNS criteria defines "Possible MD (Grade D), Probable MD (Grade C), Definite MD (Grade…
Biliopancreatic Endoscopy in Altered Anatomy
2021
Background and Objectives: Anatomical post-surgical alterations of the upper gastrointestinal (GI) tract have always been challenging for performing diagnostic and therapeutic endoscopy, especially when biliopancreatic diseases are involved. Esophagectomy, gastrectomy with various reconstructions and pancreaticoduodenectomy are among the most common surgeries causing upper GI tract alterations. Technological improvements and new methods have increased the endoscopic success rate in these patients, and the literature has been rapidly increasing over the past few years. The aim of this systematic review is to identify evidence on the available biliopancreatic endoscopic techniques performed i…
Diagnostic performance of endoscopic ultrasound through‐the‐needle microforceps biopsy of pancreatic cystic lesions: Systematic review with meta‐anal…
2020
Objectives Endoscopic ultrasound through-the-needle biopsy (EUS-TTNB) is a useful tool for differential diagnosis among pancreatic cystic lesions (PCLs). Cystic fluid cytology (CFC) is recommended by guidelines, but its diagnostic accuracy is about 50%. The aim of this meta-analysis is to assess the clinical impact of EUS-TTNB in terms of technical success (TS), histological accuracy (HA) and diagnostic yield (DY). Methods Original studies in English language on EUS-TTNB were searched in MEDLINE and EMBASE until October 2019. Diagnostic accuracy of EUS-TTNB for identification of mucinous PCLs was calculated using individual diagnostic data of patients who underwent CFC and surgery. Results …